Search Results - pei-yu+chiou

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An Acoustic Device for Large Area Single Cell Trapping and Selective Release (Case No. 2025-047)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an acoustic microfluidic platform that offers a cost-effective and practical approach for handling individual cells at the microscale. Background: Single-cell manipulation is essential for understanding cellular behavior, disease progression, and therapeutic...
Published: 1/13/2026   |   Inventor(s): Pei-Yu Chiou, Xiang Zhang
Keywords(s): acoustic microfluidics, acoustic potential wells, acoustics, cell proliferation, cell viability, Diagnostic Platform Technologies (E.G. Microfluidics), diagnostic platforms, Digital Microfluidics, disposable microfluidic platforms, high throughput, high throughput assays, high throughput testing, High-Content Screening, high-throughput cell handling, low-cost fabrication, MEMS, MEMS metasurface, micro-electromechanical systems (MEMS), Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared laser, photolithography-free fabrication, research instrumentation, scalable platform, single cell analysis, single cell analysis and testing, Single cell data, single-cell handling, single-cell manipulation, single-cell resolution, single-cell trapping
Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Mechanical, Mechanical > Instrumentation, Platforms, Platforms > Diagnostic Platform Technologies
Pulsed Laser Triggered High Speed Microfluidic Switch and Applications in Flourescent Activated Cell Sorting (Case No. 2009-063)
Summary UCLA researchers have developed a pulsed-laser triggered microfluidic switching mechanism capable of sub-100 µs switching (e.g. ~70 µs), enabling ultrafast cell/particle sorting in a microfluidic fluorescence-activated cell sorting (µFACS) platform using cavitation bubbles rather than mechanical valves. Background Flow cytometry...
Published: 9/25/2025   |   Inventor(s): Pei-Yu Chiou, Ting Hsiang Wu
Keywords(s):  
Category(s): Optics & Photonics, Optics & Photonics > Lasers, Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods
Continuous Whole-Chip 3-Dimensional Dep Cell Sorter and Its Fabrication (Case No. 2012-612)
Summary Researchers at UCLA have developed a continuous, whole-chip, three-dimensional dielectrophoretic (DEP) cell sorting device, integrating multi-layer microfluidics and electrode geometries to sort cells or particles throughout the thickness of a microfluidic chip, not merely at a single plane. Background Microfluidic cell sorting is vital in...
Published: 9/24/2025   |   Inventor(s): Pei-Yu Chiou, Yu Jui Fan, Yu Chun Kung, Kuo Wei Huang
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Optics & Photonics, Optics & Photonics > Microscopy, Electrical, Electrical > Imaging
Pulse Laser Driven High Speed, On-Demand, and Multiplexed Droplet Generator (Case No. 2013-184)
Summary UCLA researchers have developed a high-speed, on-demand microfluidic droplet platform that allows rapid and precise generation, manipulation, and merging of microdroplets for advanced lab-on-a-chip applications. The technology enables controlled droplet initiation and synchronized merging at high throughput, making it a versatile platform for...
Published: 9/24/2025   |   Inventor(s): Pei-Yu Chiou, Michael Teitell, Ting Hsiang Wu, Yue Chen, Yu Chun Kung
Keywords(s):  
Category(s): Optics & Photonics, Optics & Photonics > Lasers, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging
A Fabrication Method for High-Precision, Large-Area Acoustic Single-Cell Trapping Devices (Case No. 2025-115)
Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel fabrication method for single-cell trapping devices. Background: Single-cell analysis is critical to personalized medicine, diagnostics, and biomedical research, as it allows researchers to identify, isolate, and expand desired cell subpopulations....
Published: 10/21/2025   |   Inventor(s): Pei-Yu Chiou, Jacob Smith
Keywords(s): acoustic manipulation, acoustics, air cavity formation, cell sorting, compliant membrane acoustic patterning (CMAP), Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, high-throughput analysis, large-area arrays, MEMS, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared (NIR) pulsed laser, PDMS, PDMS membranes, single cell analysis, Single cell data, single-cell resolution, single-cell trapping
Category(s): Materials, Materials > Membranes, Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Cell Counting And Imaging, Platforms
High-Throughput Cargo Delivery Into Live Cells Using Photothermal Platforms (Case No. 2013-158)
Summary: UCLA researchers in the Department of Mechanical Engineering have developed a photothermal platform for precisely opening a cell membrane to deliver cargo into cells. Title: High-Throughput Cargo Delivery Into Live Cells Using Photothermal Platforms Background: Transferring cargo like proteins, nucleotides and particles into cells is valuable...
Published: 7/17/2025   |   Inventor(s): Pei-Yu Chiou, Michael Teitell, Ting Hsiang Wu, Yi-Chien Wu
Keywords(s): cell engineering, cellular, delivery system, Gene delivery, Laser, Microbiology, Micropump
Category(s): Electrical > Mems, Life Science Research Tools > Microfluidics And Mems
Label-Free Optical Mapping for Large-Area Biomechanical Dynamics of Multicellular Systems (Case No. 2023-290)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel label-free optical mapping method for profiling real-time biomechanical dynamics over larger areas with high spatiotemporal resolution. Background: Mapping biomechanical dynamics often involves the use of various advanced technologies to measure...
Published: 2/14/2025   |   Inventor(s): Pei-Yu Chiou, Yen-Ju Lin
Keywords(s): bioimaging, Biomechanics, cell imaging, Confocal Microscopy, dye, Fluorescence Microscope, labeling, Microscopy, Microscopy And Imaging, resolution, traction force microscopy
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Cell Counting And Imaging, Medical Devices, Medical Devices > Medical Imaging, Platforms, Platforms > Diagnostic Platform Technologies
2020-908 LASER ACTUATED SUPERCRITICAL INJECTOR (LASI)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering developed a platform that applies high-speed fluidic jet injection of biomolecules into biological samples with the use of laser actuated supercritical injector (LASI). Background: Intracellular delivery of various biomolecules has been of great importance in biomedical...
Published: 7/17/2025   |   Inventor(s): Pei-Yu Chiou
Keywords(s):  
Category(s): Life Science Research Tools > Microfluidics And Mems, Platforms > Drug Delivery, Optics & Photonics, Materials > Nanotechnology
Mechanisms and Devices Enabling Arbitrarily Shaped, Deep-Subwavelength, Acoustic Patterning
UC Case No. 2019-852SUMMARY:UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a Compliant Membrane Acoustic Patterning (CAMP) technology capable of patterning cells in an arbitrary pattern at a high resolution over a large area. BACKGROUND:Acoustic force has been investigated as a noninvasive, label-free, and...
Published: 7/17/2025   |   Inventor(s): Pei-Yu Chiou, Kuan-Wen Tung, Benjamin Wu
Keywords(s): Cell Counting/Imaging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Monitoring And Recording Systems
Category(s): Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies
Liquid Metal Enabled Multifunctional Neural Probes with Ultra-Large Tunable Stiffness
UC Case No. 2019-327SUMMARY: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel multifunctional neural probe with ultra-large tunable stiffness for electrochemical sensing and chemical delivery in the brain. BACKGROUND: Measuring brain activity has enormous applications including disease diagnosis...
Published: 7/17/2025   |   Inventor(s): Pei-Yu Chiou, Ximiao Wen, Nigel Maidment, Brian Bo Wang
Keywords(s): Medical Devices and Materials
Category(s): Medical Devices > Monitoring And Recording Systems
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