Search Results - therapeutics+%26+vaccines

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Use of Dupilumab for Disseminated Fungal Infection (UCLA Case No. 2019-706)
BACKGROUND: Dupilumab, an immunomodulatory drug that blocks IL-4 signaling, is most commonly used to treat moderate-to-severe atopic dermatitis (a form of eczema) and asthma in both adults and adolescents. While fungal infections, such as coccidioidomycosis, can be potentially treated with immunomodulatory drugs, Dupilumab does not currently have...
Published: 5/14/2024   |   Inventor(s): Manish Butte, Maria Garcia-Lloret
Keywords(s): Infectious Diseases, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Infectious Diseases
Copyright: A Comprehensive Platform to Shorten the Period Required for Vaccine Clinical Trial (Case No. 2024-148)
Summary: UCLA researchers have developed a software to accelerate vaccine clinical trial processes by modeling disease behavior and targeting future trial participants. Background: Vaccine clinical trials are time-intensive processes; ones that may be necessary during active pandemics in which time is of short supply. One of the primary factors contributing...
Published: 9/18/2024   |   Inventor(s): Akihiro Nishi
Keywords(s): Bioinformatics, Clinical Trial, Live attenuated vaccine, Public Health, Simulation & Modeling, Software & Algorithms, Therapeutics & Vaccines, Vaccines
Category(s): Software & Algorithms > Statistical Models, Software & Algorithms > Bioinformatics
Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)
UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...
Published: 2/26/2024   |   Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh
Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy
A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)
Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...
Published: 1/24/2024   |   Inventor(s): Rhonda Voskuhl, Michael Jung
Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics
Assistive Device to Aid in Identification and Use of Medications (UCLA Case No. 2022-213)
Summary: Researchers in the UCLA Stein Eye Institute have developed a medication assistive device to aid in distinguishing medication bottles and administering medications on the correct schedules for patients, especially those with visual impairment. Background: Many ophthalmic conditions are treated with eye drop medications. These treatments...
Published: 10/17/2023   |   Inventor(s): Edmund Tsui, Jie Deng, Holly Huang, Jeffrey Li, Hyeongtaek Nam, Brian Wu
Keywords(s): 3D Printing, Hospital Systems And Devices, Medical Devices and Materials, Monitoring And Recording Systems, Ophthalmology, Therapeutics & Vaccines
Category(s): Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology
Alleviating GvHD Using Engineered INKT Cells (UCLA Case No. 2023-019)
SUMMARY: Researchers in UCLA’s Department of Microbiology, Immunology & Molecular Genetics have developed an off-the-shelf cell therapy method for reduction of Graft vs Host Disease (GvHD) following hematopoietic stem cell transplantation. This approach uses engineered third-party iNKT’s to ameliorate severity of GvHD without negatively...
Published: 2/15/2024   |   Inventor(s): Lili Yang
Keywords(s): Hematology, Stem-Cell Therapy, T Cell, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Hematology
2022-222 A Wearable Aptamer Microneedle Patch for Continuous Minimally-Invasive Biomonitoring
Summary: UCLA researchers in the Department of Bioengineering have developed a novel wearable device for real-time, minimally-invasive medication monitoring. Background: Current medication dosing is determined by taking the average therapeutic dose of a small patient sample size. However, this is often inaccurate for many individuals and the recommended...
Published: 8/2/2024   |   Inventor(s): Sam Emaminejad, Shuyu Lin, Jialun Zhu, Xuanbing Cheng
Keywords(s): Biomonitoring, Drug, Drug Delivery, Drug Development, Drug Discovery, Drug Resistance, Invasiveness Of Surgical Procedures, Microneedle array, non-invasive drug monitoring, Personalized Pharmacotherapy, Pharmaceutical Drug, Pharmacokinetics, Pharmacology, Prescription Drug, Therapeutic Drug Monitoring, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Medical Devices, Materials > Nanotechnology
A Novel Device to Produce Autologous Serum Eye Drops at the Point of Care (Case No. 2021-198)
SUMMARY: UCLA researchers in the Stein and Doheny Eye Institutes have designed a device that can produce autologous serum eye drops at the point-of-care, greatly reducing the cost and complexity of the production process. BACKGROUND: Ocular surface diseases afflict hundreds of millions of people per year worldwide. Autologous serum eye drops benefit...
Published: 9/29/2023   |   Inventor(s): Justin Karlin
Keywords(s): Human Serum Albumin, Medical Devices and Materials, Targeted Therapy, Therapeutics & Vaccines
Category(s): Life Science Research Tools > Lab Equipment, Therapeutics > Ophthalmology
Optimized Lentiviral Vector for Stem Cell Gene Therapy of Hemoglobinopathies
UCLA Case No. 2017-460 Summary UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. Background Sickle...
Published: 1/23/2024   |   Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Plasmids / Vectors, Research Methods, Therapeutics & Vaccines, Viral Delivery Systems
Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Gene Therapy And Editing
2018-438 A DNA CONSTRUCT FOR TARGETING THERAPEUTIC MOLECULES TO DISEASED TISSUE BY IMMUNE CELLS
INTRODUCTION:UCLA researchers in the Departments of Integrative Biology & Physiology and Pathology & Laboratory Medicine have developed a novel construct for targeting therapeutic biological molecules specifically to diseased tissue, using immune cells as a delivery system. BACKGROUND:Drug delivery is the process of administering a pharmaceutical...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Drug Delivery, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nucleic Acids
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