Search Results - arthritis

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Monoclonal Antibody Fragments for Targeting Therapeutics to Growth Plate Cartilage
Abstract: A child's growth is dependent on the proper functioning of the growth plate, a specialized cartilage structure located at the ends of long bones and within the vertebrae. The primary function of the growth plate is to generate new cartilage, which is then converted into bone tissue and results in the lengthening of bones. Failure of the growth...
Published: 4/8/2024   |   Inventor(s): Jeffrey Baron, Sao Fong (Crystal) Cheung, Chun Lui, Dimiter Dimitrov, Zhongyu Zhu
Keywords(s): Anti-mantrilin-3 Antibody, ARTHRITIS, Baron, Cartilage, Dimitrov, Eunice Kennedy Shriver National Institute on Child Health an, Growth plate, Human Growth Hormone, monoclonal, NICHD, OSTEOARTHRITIS, Short Stature, Skeletal Dysplasia
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Ex-vivo Production of Regulatory B-Cells for Use in Auto-immune Diseases
Abstract: Regulatory B-cells (Breg) play an important role in reducing autoimmunity and reduced levels of these cells are implicated in etiology of several auto-inflammatory diseases. Despite their impact in many diseases, their physiological inducers are unknown.  Given that Bregs are a very rare B-cell, identifying factors that promote their development...
Published: 8/14/2024   |   Inventor(s): Charles Egwuagu, Ren-Wi Wang, Chengrong Yu
Keywords(s): ARTHRITIS, B-CELL, COLITIS, EYE, Multiple sclerosis, sarcoidosis
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology
Occupational Health: Wearable Kneel-Sit Support Device for Manual Labor and Heavy Industry Applications
This CDC-developed technology describes a novel ergonomic device that supports a portion of the worker's weight while kneeling, relieving the knee pressure and pain common to many manual labor occupations. Unfortunately, many of the devices that have been used in the past to relieve pressure on the knees are bulky, heavy, and of questionable durability. This...
Published: 10/28/2024   |   Inventor(s): Ova Johnston, Stephen Hudock, Steven Wurzelbacher
Keywords(s): AB1XXX, AB3GXX, AB3XXX, AE2BXX, AE2XXX, AE4XXX, AEXXXX, AFXXXX, ARTHRITIS, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DEVICE, Knee, Kneel-sit, LABOR, MINING, NIOSH, NIOSH-DART, OSHA, OSTEOARTHRITIS, SAFETY, SUPPORT, VAXXXX, VMXXXX, VPXXXX, Wearable, WEXXXX, WGXXXX, WMXXXX, WORK, WORKER, WORKER safety, WORKERS, XDXXXX, XIXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Geriatrics, Application > Occupational Safety and Health, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease
Osteoanabolism by 14-3-3zeta
Project ID: D2021-48 Background Bone loss is one of the common symptoms associated with normal aging and pathologies. An increased bone mass loss and mineral density are the primary reason for osteoporosis, arthritis, fractures, etc. Together it affects millions of individuals in the US alone. While several drugs targeting the prevention of bone...
Published: 6/18/2024   |   Inventor(s): Ritu Chakravarti, Saurabh Chattopadhyay
Keywords(s): 14-3-3z, 14-3-3 zeta, Arthritis, Autoimmune, Osteoarthritis, Rheumatoid Arthritis
Category(s): Inflammation & Immunity, Long Bone/Joint Repair
S epidermidis Lipotechoic Acid (SELTA) for Immune Modulation
NU 2014-062INVENTORSStephen F MurphyPraveen Thumbikat*Anthony Schaeffer SHORT DESCRIPTIONA bacterial cell wall component to treat chronic pelvic pain syndrome.BACKGROUNDChronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common debilitating disorder characterized by pelvic pain and lower urinary tract symptoms. However, due to limited understanding...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Arthritis, Biomedical, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Therapeutic and Prophylactic for Arthritis
Project ID: D2019-15Background Rheumatoid Arthritis (RA) is an autoimmune disease that causes swelling of the joints. Treatments are limited to anti-inflammatories, DMARDs, corticosteroids or biologics. Genetic research has identified several genetic factors that determine susceptibility to developing RA. However, there are no prophylactics or therapeutics...
Published: 6/18/2024   |   Inventor(s): Ritu Chakravarti, Bina Joe
Keywords(s): 14-3-3z, 14-3-3 zeta, Arthritis, Autoimmune
Category(s): Inflammation & Immunity
Repair and Regeneration of Articular Cartilage, and the Repair and Regeneration of Fibrocartilaginous Tissues
The invention provides methods for the protection, repair and regeneration of articular cartilage, and fibrocartilaginous tissues using recombinant parathyroid hormones, such the FDA approved biologic agent – teriparatide (Forteo®, Eli Lilly).Problem Solved by this TechnologyCurrently, the only treatments for cartilage degeneration and osteoarthritis...
Published: 5/7/2024   |   Inventor(s): Randy Rosier, Michael Zuscik, Erik Sampson, Susan Bukata, J. Edward Puzas, Regis O'keefe, Hani Awad
Keywords(s): Arthritis, Musculoskeletal, Orthopaedics
Category(s): Therapeutic