Search Results - therapeutics

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Targeted Oral Nanotherapy for IBD Treatment and Recovery
Description This technology is a lipid nanoparticle formulation composed of a proprietary blend of three major lipids identified in ginger-derived nanoparticles (GDNPs 2), isolated from edible ginger. These nanoparticles are orally administered, non-toxic, and selectively target the colon. Designed specifically for colon-specific delivery, these nanoparticles...
Published: 10/28/2025   |   Inventor(s): Didier Merlin, Chunhua Yang
Keywords(s):  
Category(s): Therapeutics, Material
Next-Generation Immunotherapy to Overcome Tumor Resistance
Description This technology is a next-generation oncolytic virus (OV) designed to address the critical challenge of tumor resistance in cancer therapy. Built on the vesicular stomatitis virus (VSV) platform, this engineered OV is capable of inducing strong, tumor-selective cell death even in apoptosis-resistant cancers. In preclinical studies, this...
Published: 10/28/2025   |   Inventor(s): Ming Luo
Keywords(s):  
Category(s): Therapeutics
Innovative Small Molecules for Safe Weight Loss and Lean Muscle Mass Preservation
Description This technology is a class of small molecules designed to treat obesity and obesity-related metabolic dysfunctions, including type 2 diabetes. These molecules show significant weight loss in preclinical mouse models without suppressing appetite or reducing physical activity. Importantly, they preserve lean muscle mass while reducing fat,...
Published: 10/28/2025   |   Inventor(s): Chong Hyun Shin
Keywords(s):  
Category(s): Therapeutics
Antisense oligonucleotides for rescuing splicing mutations in hotspot exons
An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons Overview Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying...
Published: 10/29/2025   |   Inventor(s): William Fairbrother, Jeremiah Buerer, Chaorui Duan
Keywords(s):  
Category(s): Assay, Therapeutics
Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)
Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...
Published: 10/16/2025   |   Inventor(s): Andrew Leuchter, Juliana Corlier, Thomas Valles
Keywords(s): Bioelectromagnetics, Brain, Deep Brain Stimulation, Electrical Brain Stimulation, energy-efficient, frequency modulation, Magnetic Field, Medical Device, medication efficacy, neural information, neural network, neural networks, neural signals, neural stimulation, neurobehavioral impairment, Neurocognitive, neurological disorders, Neuromodulation, Neuron, neurons, neuroscience, Neurostimulation, pulsed load modulation, therapy, treatment efficacy
Category(s): Medical Devices, Medical Devices > Neural Stimulation, Life Science Research Tools, Therapeutics > CNS and Neurology, Therapeutics
Balloon Catheter for Thermal Ablation Protection (Case No. 2024-210)
Summary UCLA researchers have developed a novel planar balloon catheter that reliably separates and protects organs during thermal ablation procedures. By creating a sheet-like thermal barrier, the device mitigates unintended injury to nearby healthy tissues—particularly the stomach and bowel—thereby enabling safer and more effective treatment...
Published: 9/26/2025   |   Inventor(s): David Lu
Keywords(s): catheter, Catheterization, Swan-Ganz catheter
Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Oncology, Therapeutics > Renal, Therapeutics
Mass-Tagged Nucleic Acids for Effective Industrialization of RNA Therapeutics
Opportunity RNA-based therapeutics, such as mRNA vaccines and miRNA drugs, are rapidly transforming modern medicine. However, the manufacturing and distribution of these complex molecules present significant quality assurance (QA) and quality control (QC) challenges. Issues such as degradation, incomplete transcripts, sequence variability, and contamination...
Published: 9/22/2025   |   Inventor(s): Marie Migaud, Faisal Hayat
Keywords(s):  
Category(s): All Technologies, Cancer Therapeutics, Medical Device or Method, Therapeutics, Biomarkers
Adaptable Cueing Trainer for Physical Therapy, Training, and Rehabilitation
Opportunity Proper technique is critical for effective rehabilitation and strength training, particularly for upper extremity exercises that restore mobility and prevent injury. In clinical and athletic settings, therapists and coaches often must supervise multiple patients or athletes at once, making it difficult to provide continuous individualized...
Published: 9/22/2025   |   Inventor(s): Kevin Strehler, Shawn Drake
Keywords(s):  
Category(s): All Technologies, Medical Device or Method, Therapeutics
Self-Amplifying RNA Form of a Constitutively-Active Sting Protein for Enhancing T-Cell Response to Antigen-Presenting Cells (UCLA Case No. 2020-771)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for delivering RNA to induce an immune response to cancer cells. BACKGROUND: Cancer therapy continues to remain a challenge despite improvements in detection and clinically available therapies. Recently, improvements to this field have been mainly in the...
Published: 10/22/2025   |   Inventor(s): William Gelbart
Keywords(s): Adenoviridae
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Diagnostic Markers > Targets And Assays
Self-Powered Electrical Stimulation Magnetoelastic Bandage for Accelerated Wound Healing (Case No. 2025-99N)
Reference: UCLA Case No. 2025-99N Please reach out to our office for more information.
Published: 10/10/2025   |   Inventor(s): Jun Chen, Kanishk Rai, Song Li, Il Woo Ock, Haochen Nan
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Aesthetic Medicine, Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Flexible Electronics
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