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Search Results - therapeutics
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A novel method to achieve polymeric nanoparticles loaded with peptide
therapeutics
, which display high encapsulation efficiency, low burst release, and long acting sustained release profiles
A novel method to achieve polymeric nanoparticles loaded with peptide
therapeutics
, which display high encapsulation efficiency, low burst release, and long acting sustained release profiles. Overview A major challenge in the field of peptide and protein therapeutics is effective administration and subsequent delivery to the site of action. Due to...
Published: 8/13/2025
|
Inventor(s):
Edith Mathiowitz
,
Cameron Baptista
Keywords(s):
Category(s):
Therapeutics
A novel molecular target for the treatment of heart failure with preserved ejection fraction
Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy Overview Cardiac hypertrophy, a key risk factor for heart failure and sudden cardiac death, arises from hemodynamic and neurohormonal stress, often culminating in adverse remodeling. While much of the focus has been on activators of hypertrophic signaling, this technology identifies...
Published: 8/13/2025
|
Inventor(s):
Mukesh Jain
,
Xudong Liao
,
Tapatee Das
,
Yosuke Nagai
Keywords(s):
Category(s):
Therapeutics
A photocrosslinkable bone derived biomaterial for tissue engineering applications
Summary Demineralized bone matrix has been widely used in the clinic to heal bone injuries due to its remarkable regenerative properties. However, this is not a material that can be synthesized in large batches, with highly reproducible chemistry, and cannot be set/polymerized in-situ for precise adaptation. BoneMA is photopolymerizable material that...
Published: 7/23/2025
|
Inventor(s):
Luiz Bertassoni
,
Avathamsa Athirasala
Keywords(s):
Category(s):
Therapeutics
,
Device
Methods and Systems for Low-Cost Medical Image Annotation Using Non-experts (Case No. 2025-108)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an AI-based interface designed to enable individuals without specialized training to identify arthritis in medical imaging. Background: The use of artificial intelligence (AI) for medical imaging analysis holds great promise for the future of healthcare....
Published: 7/23/2025
|
Inventor(s):
Xiang Chen
,
Youngseung Jeon
,
Christopher Hwang
Keywords(s):
3D tissue imaging
,
AI-guided diagnostics
,
AI-guided medical imaging
,
AI-guided medical intervention
,
arthritis
,
Artifical Intelligence (Machine Learning, Data Mining)
,
Artificial Intelligence
,
artificial intelligence algorithms
,
artificial intelligence augmentation
,
artificial intelligence/machine learning models
,
Artificial Neural Network
,
bioimaging
,
Computer-Aided Diagnosis
,
computer-aided radiology
,
Diagnostic Markers & Platforms
,
Diagnostic Test
,
diagnostics
,
generative artificial intelligence
,
Image Analysis
,
Image Resolution
,
Imaging
,
infrared thermal imaging
,
Machine Learning
,
machine learning modeling
,
machine perception
,
Magnetic Resonance Imaging Medical Physics
,
Magnetic Resonance Imaging Pathology
,
Medical artificial intelligence (AI)
,
Medical diagnostics
,
Medical Imaging
,
Microscopy And Imaging
,
non-invasive imaging
,
osteoarthritis
,
radial MRI
,
radiologic imaging
,
Radiology
,
Radiology / Radiomitigation
,
radiosurgery
Category(s):
Software & Algorithms
,
Software & Algorithms > AI Algorithms
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Software & Algorithms > Digital Health
,
Software & Algorithms > Image Processing
,
Life Science Research Tools
,
Life Science Research Tools > Lab Equipment
,
Life Science Research Tools > Microscopy And Imaging
,
Medical Devices
,
Medical Devices > Medical Imaging
,
Medical Devices > Monitoring And Recording Systems
,
Therapeutics
,
Therapeutics
> Musculoskeletal Disease
,
Therapeutics
> Radiology
Targeted Therapy for Inflammatory Diseases and Cancer
Description This technology is a biologic therapy that modulates macrophage activity to redirect immune responses, reduces inflammation, and suppresses tumor growth. Preclinical studies in mouse models show that treatment with this technology significantly reduces tumor burden, decreases metastasis spread, and reshapes the tumor microenvironment. These...
Published: 7/18/2025
|
Inventor(s):
Zhi-Ren Liu
,
Guangda Peng
Keywords(s):
Category(s):
Therapeutics
Highly Effective Monoclonal Antibodies for Gonorrhea Treatment
Description This technology is a series of novel monoclonal antibodies (mAbs) developed to specifically block the growth of N. gonorrhoeae. In preclinical studies, select mAbs not only reduced clinical symptoms and bacterial load in mice but also conferred cross-protection against invasive Neisseria meningitidis (Nme) infection. These findings support...
Published: 7/18/2025
|
Inventor(s):
Cynthia Cornelissen
,
Julie Stoudenmire-Saylor
Keywords(s):
Category(s):
Therapeutics
Smart ROS-Triggered Prodrug Platform for Cancer and Infectious Disease Treatment
Description This technology is a novel class of ROS (Reactive Oxygen Species)-sensitive linkers and related prodrugs designed for the targeted treatment of cancer and infectious diseases. This technology utilizes the elevated ROS levels present in diseased tissues to selectively activate therapeutic compounds, enabling precise drug release at the site...
Published: 7/18/2025
|
Inventor(s):
Binghe Wang
,
Shubham Bansal
,
Mohammed Kondengadan
Keywords(s):
Category(s):
Therapeutics
Powerful Formulation for Respiratory Infection Prevention and Treatment
Description This technology is a set of innovative pharmaceutical formulations that utilize metabolites derived from specific gut microbiota to prevent respiratory infections and enhance immune health. Formulations are available for both oral and intranasal administration, offering flexibility and ease of use. By strengthening the immune system's...
Published: 5/14/2025
|
Inventor(s):
Andrew Gewirtz
,
Vu Le Ngo
Keywords(s):
Category(s):
Therapeutics
Potent, Safer Respiratory Syncytial Virus
Therapeutics
Description This technology is a cutting-edge antiviral technology designed to treat respiratory syncytial virus (RSV) by potently inhibiting RSV RNA synthesis. This technology has shown remarkable efficacy in preclinical mouse models, significantly reducing lung virus load. With the potential for oral administration and reduced toxicity, this breakthrough...
Published: 6/26/2025
|
Inventor(s):
Richard Plemper
,
Julien Sourimant
Keywords(s):
Category(s):
Therapeutics
Highly Effective Nanobodies to Treat Henipavirus Infections
Description This technology is a series of small molecule
therapeutics
to treat Henipavirus infections, which is a dangerous group of viruses that cause severe diseases in both humans and animals. These nanobodies are engineered to recognize and bind to specific proteins on Nipah and Hendra viruses, effectively cross-neutralizing different strains...
Published: 4/8/2025
|
Inventor(s):
Jianliang Xu
Keywords(s):
Category(s):
Therapeutics
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