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Search Results - therapeutics
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Novel Curcumin Derivatives with Enhanced Anti-Inflammatory Properties
SUMMARY This technology comprises two novel curcumin derivatives - compounds D3 and D4 - with potent anti-inflammatory properties. These compounds effectively inhibit a key inflammatory signaling pathway, offering enhanced therapeutic potential over traditional curcumin. The technology provides improved bioactive compounds for nutraceutical and pharmaceutical...
Published: 12/9/2025
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Inventor(s):
Keywords(s):
Category(s):
Natural Products
,
Research Tools
,
Therapeutics
Genetic engineering approach for enhancing recombinant protein production by mammalian cells
Summary Vanderbilt researchers have developed a novel approach to enhance recombinant protein production in mammalian cell culture systems through metabolic engineering. By overexpressing specific metabolic proteins in these cells, this technology achieves higher monoclonal antibody titers and increased cell-specific productivity compared to conventional...
Published: 12/9/2025
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Inventor(s):
Keywords(s):
Category(s):
Biomanufacturing
,
Research Tools
,
Therapeutics
Oxygen-Tolerant Probiotic Therapy for Intestinal Inflammatory Diseases
Summary Anaerobic bacteria used in current probiotic compositions cannot tolerate the oxygen stress found in the gut during inflammation, reducing their effectiveness in restoring a healthy gut microbiome. Vanderbilt researchers have engineered Bacteroides thetaiotaomicron, an obligate anaerobe, to endure oxygen-rich conditions in the gut. This advancement...
Published: 12/2/2025
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Inventor(s):
Keywords(s):
Category(s):
Research Tools
,
Therapeutics
In Vivo Delivery and Removal of Metals
Current State of the Art: Gold-based drugs are currently used in the treatment of rheumatoid arthritis, have demonstrated efficacy in clinical trials in malaria treatment, and most recently have significantly reduced the reservoir of viral DNA and the population of long-lived HIV-infected memory CD4+ cells in pre-clinical studies. In...
Published: 11/18/2025
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Inventor(s):
John Wataha
,
Regina Messer
,
Jill Lewis
,
David Hobbs
Keywords(s):
Biofilter
,
Heavy metals
,
Titanates
Category(s):
Therapeutics
Targeted Oral Nanotherapy for IBD Treatment and Recovery
Description This technology is a lipid nanoparticle formulation composed of a proprietary blend of three major lipids identified in ginger-derived nanoparticles (GDNPs 2), isolated from edible ginger. These nanoparticles are orally administered, non-toxic, and selectively target the colon. Designed specifically for colon-specific delivery, these nanoparticles...
Published: 10/28/2025
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Inventor(s):
Didier Merlin
,
Chunhua Yang
Keywords(s):
Category(s):
Therapeutics
,
Material
Next-Generation Immunotherapy to Overcome Tumor Resistance
Description This technology is a next-generation oncolytic virus (OV) designed to address the critical challenge of tumor resistance in cancer therapy. Built on the vesicular stomatitis virus (VSV) platform, this engineered OV is capable of inducing strong, tumor-selective cell death even in apoptosis-resistant cancers. In preclinical studies, this...
Published: 10/28/2025
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Inventor(s):
Ming Luo
Keywords(s):
Category(s):
Therapeutics
Innovative Small Molecules for Safe Weight Loss and Lean Muscle Mass Preservation
Description This technology is a class of small molecules designed to treat obesity and obesity-related metabolic dysfunctions, including type 2 diabetes. These molecules show significant weight loss in preclinical mouse models without suppressing appetite or reducing physical activity. Importantly, they preserve lean muscle mass while reducing fat,...
Published: 10/28/2025
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Inventor(s):
Chong Hyun Shin
Keywords(s):
Category(s):
Therapeutics
Antisense oligonucleotides for rescuing splicing mutations in hotspot exons
An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons Overview Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying...
Published: 10/29/2025
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Inventor(s):
William Fairbrother
,
Jeremiah Buerer
,
Chaorui Duan
Keywords(s):
Category(s):
Assay
,
Therapeutics
Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)
Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...
Published: 10/16/2025
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Inventor(s):
Andrew Leuchter
,
Juliana Corlier
,
Thomas Valles
Keywords(s):
Bioelectromagnetics
,
Brain
,
Deep Brain Stimulation
,
Electrical Brain Stimulation
,
energy-efficient
,
frequency modulation
,
Magnetic Field
,
Medical Device
,
medication efficacy
,
neural information
,
neural network
,
neural networks
,
neural signals
,
neural stimulation
,
neurobehavioral impairment
,
Neurocognitive
,
neurological disorders
,
Neuromodulation
,
Neuron
,
neurons
,
neuroscience
,
Neurostimulation
,
pulsed load modulation
,
therapy
,
treatment efficacy
Category(s):
Medical Devices
,
Medical Devices > Neural Stimulation
,
Life Science Research Tools
,
Therapeutics
> CNS and Neurology
,
Therapeutics
Balloon Catheter for Thermal Ablation Protection (Case No. 2024-210)
Summary UCLA researchers have developed a novel planar balloon catheter that reliably separates and protects organs during thermal ablation procedures. By creating a sheet-like thermal barrier, the device mitigates unintended injury to nearby healthy tissues—particularly the stomach and bowel—thereby enabling safer and more effective treatment...
Published: 9/26/2025
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Inventor(s):
David Lu
Keywords(s):
catheter
,
Catheterization
,
Swan-Ganz catheter
Category(s):
Medical Devices
,
Medical Devices > Surgical Tools
,
Therapeutics
> Oncology
,
Therapeutics
> Renal
,
Therapeutics
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