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Anti-LILRB5 Monoclonal Antibodies for Therapeutic and Diagnostic Use
Tumor microenvironment (TME) plays a critical role in regulating immune responses to tumors. UTHealth Houston and UTSW researchers discovered certain membrane tyrosine kinase Eph receptors, including EphA7 and EphB1, specifically bind to the immune inhibitory receptors leukocyte Ig-like receptor family B 5 (LILRB5) and result in bi-directional signaling....
Published: 2/16/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
,
Oncology
Anti-LILRB1 Monoclonal Antibodies for Therapeutic and Diagnostic Use
LILRB1 expression on myeloid cells regulates both innate and adaptive immune responses. Researchers at UTHealth Houston and UTSW developed novel agonistic anti-LILRB1 monoclonal antibodies (mAbs) for autoimmune and inflammatory disease treatments, and novel antagonistic anti-LILRB1 mAbs for cancer immunotherapies. Background LILRB1, a member of the...
Published: 2/16/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
,
Oncology
Anti-LAIR1 Monoclonal Antibodies for Therapeutic and Diagnostic Use
Leukocyte associated immunoglobulin like receptor 1 (LAIR1 or CD305) is an immune inhibitory receptor expressing on most immune cell types. Researchers at UTHealth Houston and UTSW generated novel antagonistic anti-LAIR1 monoclonal antibodies (mAbs) that inhibited the activity of immunosuppressive myeloid cells and reactivated T cells from cancer patients...
Published: 2/16/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
,
Oncology
Anti-LILRB3 Monoclonal Antibodies for Therapeutic and Diagnostic Use
UTHealth Houston and UTSW researchers discovered that LILRB3 stimulates NF-κB signaling and enhances acute myeloid leukemia (AML) cells. They generated a panel of novel anti-LILRB3 monoclonal antibodies (mAbs), which exhibited increasing killing of leukemia cells and promoting cytotoxic T cell activity against tumors. Background Leukocyte immunoglobulin-like...
Published: 2/16/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Oncology
,
Therapeutics
CAR-T Cells Targeting LILRB4 for Therapeutic and Diagnostic Use
CAR-T cell therapy development for AML has been limited by lack of an antigen with high specificity for AML cells that is not present on normal hematopoietic stem cells. UTHealth Houston and UTSW researchers discovered that leukocyte immunoglobulin-like receptor-B4 (LILRB4) is a tumor-associated antigen highly expressed on monocytic AML cells. They...
Published: 2/16/2026
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Inventor(s):
Keywords(s):
Category(s):
Cell Therapies
,
Biologics
,
Oncology
,
Therapeutics
A Wearable Magnetoelastic Patch for Cervical Spines Care (Case No. 2026-076)
Summary: UCLA researchers have developed a soft, wearable magnetoelastic patch designed for real-time, non-invasive monitoring of cervical spine pressure and motion, enabling early detection and personalized care for infants with potential neck or spine disorders. Background: Infant cervical spine injuries present a significant diagnostic challenge...
Published: 2/4/2026
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Inventor(s):
Jun Chen
Keywords(s):
Neurosurgery/Spine
Category(s):
Diagnostic Markers > Pediatrics
,
Electrical > Electronics & Semiconductors
,
Electrical > Flexible Electronics
,
Electrical > Sensors
,
Materials > Fabrication Technologies
,
Mechanical > Sensors
,
Medical Devices > Monitoring And Recording Systems
,
Software & Algorithms > AI Algorithms
,
Therapeutics
Novel Channelrhodopsins for Optogenetics Gene Therapy
When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while...
Published: 1/15/2026
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Inventor(s):
John Spudich
,
Elena G Govorunova
,
Oleg A Sineshchekov
Keywords(s):
Category(s):
Therapeutics
,
Research Materials
A Novel, Human-Derived HER2 Antibody for Cancer
Therapeutics
and Diagnostics
Summary Vanderbilt researchers have discovered a human-derived antibody that recognizes HER2, a protein overexpressed in various cancers. These antibodies offer potential novel cancer
therapeutics
and diagnostic tools with improved immunological compatibility compared to humanized antibody alternatives. Addressed Need The HER2 protein is overexpressed...
Published: 1/20/2026
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Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
SLC13A3 Monoclonal Antibody for Therapeutic and Diagnostic Use
Description: SLC13A3 is revealed here, for the first time based on our evaluation, as a transporter for itaconate in tumor cells which plays a role in promoting tumor ferroptosis resistance, thereby weakening tumor immunity and immune checkpoint blockade (ICB). World renowned immuno-oncology leaders from UTHealth and University of Michigan (UMich)...
Published: 1/15/2026
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Inventor(s):
Keywords(s):
Category(s):
Therapeutics
,
Oncology
Malassezia-Secreted Factor with Antibiotic Activity
1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...
Published: 1/8/2026
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Inventor(s):
Matthew Barber
,
Caitlin Kowalski
Keywords(s):
Category(s):
Therapeutics
,
Diagnostics
,
Research Tools
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