Search Results - therapeutics

582 Results Sort By:
Novel Growth Factor for Liver Regeneration
Summary Liver transplantation is the only cure for end-stage liver disease, but donor organ scarcity limits access for millions. Split liver transplantation could help bridge this gap, but the regeneration of partial organs is critical to broadly implementing this approach. Vanderbilt University researchers have identified a growth factor that promotes...
Published: 11/21/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Research Tools, Therapeutics
Specific Protein Tyrosine Phosphatase Inhibitor for Cancer
Specific Protein Tyrosine Phosphatase Inhibitor for Cancer (CHMC Ref. Id: 2007-0514) Overview: Many protein tyrosine phosphatase (PTPs) are over-expressed in cancers. Often they dephosphorylate and activate the oncogenic protein tyrosine kinase (PTK) c-src, which accounts for 70% of the elevated PTK activity in breast cancer. Thus, PTPs...
Published: 10/16/2024   |   Inventor(s): Rashmi Hegde
Keywords(s): 1 - Therapeutic
Category(s): Therapeutics
Malaria transmission blocking using ELQ-infused bed nets
Summary Insecticide-treated mosquito bed nets reduce the transmission of malaria, but mosquitos have developed resistance to insecticides leading to reduced efficacy. Our new technology is a chemical solution for mosquito nets that kills malaria, is less prone to drug-resistance and is not toxic to humans. Technology Overview Insecticide-treated...
Published: 10/15/2024   |   Inventor(s): Michael Riscoe, Aaron Nilsen, Joseph (Stone) Doggett, Flaminia Catteruccia, Douglas (Doug) Paton
Keywords(s): Therapeutics, Therapeutics - Infectious Diseases, Therapeutics - Other
Category(s): Therapeutics, Device, Chemical
S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use
Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Oncology, Therapeutics
LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Therapeutics
Novel Channelrhodopsins for Optogenetics Gene Therapy (CCRs and KCRs)
When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Kalium (potassium)-conducting channelrhodopsins (KCRs) have the potential for optogenetic applications and as therapeutic agents for electrically active cell mediated disorders,...
Published: 10/21/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Research Materials, Therapeutics, Neurology/Neurosurgery
Compound Drug Delivery System (Case No. 2024-015)
Summary: Researchers in UCLA’s Department of Orthopaedic Surgery have developed novel multi-drug delivery system that is compatible with standard syringe-based administration routes. Background: Drug compounding is the process of combining two or more medications to meet the needs of individual patients. Surgeons may mix different anesthetics...
Published: 9/11/2024   |   Inventor(s): Fabrizio Billi, Mauricio Silva, Aaron Kavanaugh
Keywords(s):  
Category(s): Therapeutics, Platforms, Platforms > Drug Delivery, Medical Devices
Enhancing Methotrexate Efficacy for Ectopic Pregnancy Treatment
Methotrexate (MTX) loaded polymersomes are used to preferentially deliver MTX to sites of ectopic pregnancy Background Ectopic pregnancy, abnormal pregnancy implantation at sites other than in the uterine cavity, leads to internal bleeding if not identified and treated in a timely manner, and is a major cause of maternal morbidity and mortality....
Published: 9/5/2024   |   Inventor(s): Olena Taratula, Oleh Taratula, Maureen Baldwin, Leslie Myatt, Babak Mamnoon
Keywords(s):  
Category(s): Therapeutics
PD1+CD38+ CD8 T-cells, a marker for anti-PD1 therapy resistance and selection marker for treatment or continuation of treatment of patients, and a target to reverse resistance
PD1+CD38+ CD8 T-cells, a marker for anti-PD1 therapy resistance and selection marker for treatment or continuation of treatment of patients, and a target to reverse resistance Current state of the artA number of new checkpoint inhibitors are used in cancer therapy. PD-1 inhibitors such as Pembrolizumab (Keytruda), Nivolumab (Opdivo), and Cemiplimab...
Published: 8/29/2024   |   Inventor(s): Samir Khleif, Vivek Verma, Seema Gupta
Keywords(s):  
Category(s): Therapeutics
Combination therapy for the treatment of triple negative breast cancer
Summary Researchers at OHSU have discovered a novel combination therapy for triple negative breast cancer, which increases immune responses, causes tumor regression and improves survival in animal models. Technology Overview Triple negative breast cancer (TNBC) represents one of the most aggressive forms of all breast cancer subtypes with a very...
Published: 9/17/2024   |   Inventor(s): Sanjay Malhotra, Lisa Coussens, Dhanir Tailor, Sushil Kumar, Arpit Dheeraj
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
1 2 3 4 5 6 7 8 9 10 ...