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Antisense oligonucleotides for rescuing splicing mutations in hotspot exons

An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons Overview Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying...

Published: 10/23/2025 | Inventor(s): William Fairbrother, Jeremiah Buerer, Chaorui Duan

Keywords(s):

Category(s): Assay, Therapeutics

Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)

Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...

Published: 10/16/2025 | Inventor(s): Andrew Leuchter, Juliana Corlier, Thomas Valles

Keywords(s): Bioelectromagnetics, Brain, Deep Brain Stimulation, Electrical Brain Stimulation, energy-efficient, frequency modulation, Magnetic Field, Medical Device, medication efficacy, neural information, neural network, neural networks, neural signals, neural stimulation, neurobehavioral impairment, Neurocognitive, neurological disorders, Neuromodulation, Neuron, neurons, neuroscience, Neurostimulation, pulsed load modulation, therapy, treatment efficacy

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Life Science Research Tools, Therapeutics > CNS and Neurology, Therapeutics

Balloon Catheter for Thermal Ablation Protection (Case No. 2024-210)

Summary UCLA researchers have developed a novel planar balloon catheter that reliably separates and protects organs during thermal ablation procedures. By creating a sheet-like thermal barrier, the device mitigates unintended injury to nearby healthy tissues—particularly the stomach and bowel—thereby enabling safer and more effective treatment...

Published: 9/26/2025 | Inventor(s): David Lu

Keywords(s): catheter, Catheterization, Swan-Ganz catheter

Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Oncology, Therapeutics > Renal, Therapeutics

Mass-Tagged Nucleic Acids for Effective Industrialization of RNA Therapeutics

Opportunity RNA-based therapeutics, such as mRNA vaccines and miRNA drugs, are rapidly transforming modern medicine. However, the manufacturing and distribution of these complex molecules present significant quality assurance (QA) and quality control (QC) challenges. Issues such as degradation, incomplete transcripts, sequence variability, and contamination...

Published: 9/22/2025 | Inventor(s): Marie Migaud, Faisal Hayat

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Category(s): All Technologies, Cancer Therapeutics, Medical Device or Method, Therapeutics, Biomarkers

Adaptable Cueing Trainer for Physical Therapy, Training, and Rehabilitation

Opportunity Proper technique is critical for effective rehabilitation and strength training, particularly for upper extremity exercises that restore mobility and prevent injury. In clinical and athletic settings, therapists and coaches often must supervise multiple patients or athletes at once, making it difficult to provide continuous individualized...

Published: 9/22/2025 | Inventor(s): Kevin Strehler, Shawn Drake

Keywords(s):

Category(s): All Technologies, Medical Device or Method, Therapeutics

Self-Amplifying RNA Form of a Constitutively-Active Sting Protein for Enhancing T-Cell Response to Antigen-Presenting Cells (UCLA Case No. 2020-771)

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for delivering RNA to induce an immune response to cancer cells. BACKGROUND: Cancer therapy continues to remain a challenge despite improvements in detection and clinically available therapies. Recently, improvements to this field have been mainly in the...

Published: 10/22/2025 | Inventor(s): William Gelbart

Keywords(s): Adenoviridae

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Diagnostic Markers > Targets And Assays

Self-Powered Electrical Stimulation Magnetoelastic Bandage for Accelerated Wound Healing (Case No. 2025-99N)

Reference: UCLA Case No. 2025-99N Please reach out to our office for more information.

Published: 10/10/2025 | Inventor(s): Jun Chen, Kanishk Rai, Song Li, Il Woo Ock, Haochen Nan

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Category(s): Therapeutics, Therapeutics > Aesthetic Medicine, Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Flexible Electronics

Human antibodies targeting a novel flu epitope for use as a universal flu vaccine and treatment

Technology Summary: Scientists at Vanderbilt have discovered a new class of human antibodies specific to a novel target for the detection, prevention, and treatment of influenza A viruses (IAV). Using structural characterization, they have identified a novel antigenic site on the hemagglutin (HA) head domain that may be targeted by multiple antibodies...

Published: 8/28/2025 | Inventor(s):

Keywords(s): Infectious Disease

Category(s): Therapeutics, Vaccines

Targeting PD-1H to treat Acute Myeloid Leukemia (AML)

Summary Despite the success of immune checkpoint inhibitors (ICI) like anti-PD-1 in treating other cancers, these therapeutics have not been demonstrated to effectively treat acute myeloid leukemia (AML). Vanderbilt researchers have identified PD-1H as a potential target for treating AML, opening the door for effective therapy using an ICI molecule. Addressed...

Published: 8/28/2025 | Inventor(s):

Keywords(s):

Category(s): Therapeutics

Bioelectric Neuromodulation Methods for Hematopoiesis Regulation During Chemotherapy (Case No. 2020-382)

Summary: UCLA researchers in the Department of Bioengineering have developed an electrical neuromodulation method to accelerate recovery from deleterious chemotherapy side effects to improve patient outcome. Background: Chemotherapy works by targeting and killing fast-growing cancer cells using anti-cancer drugs. However, because these drugs lack...

Published: 10/21/2025 | Inventor(s): Wentai Liu

Keywords(s): algorithmic cancer detection, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, cancer inhibition, cancer metabolism, Cancer stem cells, cancer target, castration resistant prostate cancer, Chemotherapy, head and neck cancer, lympathic cancers, lymphatic cancer, Mesenchymal Stem Cell Derived Cancer Cells, Neuromodulation, non-small cell lung cancer, Orthotopic cancer models, Pancreatic cancer, prostate cancer, small cell cancer, small cell lung cancer, small cell prostate cancer

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Chemical, Electrical, Therapeutics, Therapeutics > Oncology

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