Search Results - therapeutics

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Highly Effective Nanobodies to Treat Henipavirus Infections
Description This technology is a series of small molecule therapeutics to treat Henipavirus infections, which is a dangerous group of viruses that cause severe diseases in both humans and animals. These nanobodies are engineered to recognize and bind to specific proteins on Nipah and Hendra viruses, effectively cross-neutralizing different strains...
Published: 4/8/2025   |   Inventor(s): Jianliang Xu
Keywords(s):  
Category(s): Therapeutics
Highly Effective Small Molecules for Cancer Treatment
Description This technology is a series of innovative small molecules demonstrating significant in-vitro anticancer activity. Isolated from a previously unstudied medicinal plant species, these compounds expand the potential of natural products in drug discovery. Previous studies on related plant species have identified compounds with a broad spectrum...
Published: 4/10/2025   |   Inventor(s): Paulos Yohannes, Binghe Wang
Keywords(s):  
Category(s): Therapeutics
Mechanical Cutaneous Nerve Stimulation for Reducing Epileptic Seizures and Perceived Pain (Case No. 2016-686-3)
Summary: UCLA researchers have developed a novel, non-invasive pain management device that uses mechanical vibrations to activate cutaneous sensory fibers, reducing epileptic seizures, masking pain perception and alleviating associated symptoms. Background: Unexpected death due to epilepsy is a pressing concern, with an estimated incidence of 1.2...
Published: 4/4/2025   |   Inventor(s): Ronald Harper, Eberhardt Sauerland, Christopher Degiorgio
Keywords(s): low-power device, Medical Device, Medical Devices and Materials, minimally invasive device, Neuropathology, Neurostimulation, non-invasive, Pain Treatment, sample-to-answer devices, Semiconductor Device, Smart medical device, Stroke, Transcutaneous Electrical Nerve Stimulation, Vibration monitoring, Vibration sensing, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > CNS and Neurology
First in class use of the estrogen receptor-b agonist in treating Angelman syndrome and relevant autism spectrum disorders
Overview Angelman syndrome is a genetic disorder caused by UBE3A gene dysfunction, leading to cognitive impairment, motor coordination issues, and developmental delays. Research suggests that oligodendroglial dysfunction, which affects myelination in the brain, contributes to these conditions. Based on the research, this invention discloses a novel...
Published: 3/17/2025   |   Inventor(s): Yu-Wen Huang, Xin Yang
Keywords(s):  
Category(s): Genetic Diseases, Therapeutics, Therapy Targets
A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)
Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...
Published: 3/27/2025   |   Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen
Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer
Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors
Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...
Published: 2/26/2025   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz
Keywords(s):  
Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular
Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke
Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...
Published: 4/8/2025   |   Inventor(s): Binghe Wang, Yueqin Zheng
Keywords(s):  
Category(s): Therapeutics, Research Tool
Anti-Biofilm Agent Effective At Low Doses
Description This technology is a compound and method to break down a Pseudomonas aeruginosa biofilm. Biofilms are clusters of bacteria that are attached to other bacterial cells and to the surface as a slimy coating, often resistant to antibiotics. The cells within the biofilm produce extracellular polymeric matrices which are capable of adhering...
Published: 3/12/2025   |   Inventor(s): Charles Derby, Eric Gilbert, Phang-Cheng Tai, Marwa Ahmed
Keywords(s):  
Category(s): Therapeutics
Highly Effective Therapeutics to Overcome Antibiotic Resistance
Description This technology is a series of small molecules that enhance antibiotic effectiveness in treating bacterial infections. These compounds not only sensitizes resistant bacteria to enable more effective treatment, but also act as an antibiotic adjuvant to allow lower antibiotic doses to be used. The lead compound has been shown to sensitize...
Published: 3/24/2025   |   Inventor(s): Binghe Wang, David Boykin, Manjusha Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu
Keywords(s):  
Category(s): Therapeutics
Selective Chemotherapeutics That Specifically Target Tumor Cells
Description This technology is a series of synthesized cyanines that display high binding affinity to quadruplex DNA with high selectivity over duplex sequences. Cyanines are a class of small molecules that could be developed as potential G-quadruplex targeting agents. These cyanines have been designed to achieve highly selective binding to DNA G-quadruplexes...
Published: 2/21/2025   |   Inventor(s): Maged Henary, W. David Wilson
Keywords(s):  
Category(s): Therapeutics
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