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Search Results - therapeutics
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Novel Channelrhodopsins for Optogenetics Gene Therapy
When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while...
Published: 1/15/2026
|
Inventor(s):
John Spudich
,
Elena G Govorunova
,
Oleg A Sineshchekov
Keywords(s):
Category(s):
Therapeutics
,
Research Materials
A Novel, Human-Derived HER2 Antibody for Cancer
Therapeutics
and Diagnostics
Summary Vanderbilt researchers have discovered a human-derived antibody that recognizes HER2, a protein overexpressed in various cancers. These antibodies offer potential novel cancer
therapeutics
and diagnostic tools with improved immunological compatibility compared to humanized antibody alternatives. Addressed Need The HER2 protein is overexpressed...
Published: 1/20/2026
|
Inventor(s):
Keywords(s):
Category(s):
Diagnostics
,
Therapeutics
SLC13A3 Monoclonal Antibody for Therapeutic and Diagnostic Use
Description: SLC13A3 is revealed here, for the first time based on our evaluation, as a transporter for itaconate in tumor cells which plays a role in promoting tumor ferroptosis resistance, thereby weakening tumor immunity and immune checkpoint blockade (ICB). World renowned immuno-oncology leaders from UTHealth and University of Michigan (UMich)...
Published: 1/15/2026
|
Inventor(s):
Keywords(s):
Category(s):
Therapeutics
,
Oncology
Malassezia-Secreted Factor with Antibiotic Activity
1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...
Published: 1/8/2026
|
Inventor(s):
Matthew Barber
,
Caitlin Kowalski
Keywords(s):
Category(s):
Therapeutics
,
Diagnostics
,
Research Tools
Moderate-Affinity Affibodies for Controlled Protein Delivery and Bioactivity
1. Technology Overview The invention introduces a novel method for controlled protein delivery and bioactivity using moderate-affinity affibodies. These 58-amino acid peptides can specifically bind to various proteins, allowing for the controlled release or sequestration of multiple payloads within a single vehicle. The technology leverages the conjugation...
Published: 1/8/2026
|
Inventor(s):
Marian Hettiaratchi
,
Henry Hochstatter
,
Veronica Spaulding
,
Jonathan Dorogin
,
Alycia Galindo
,
Chandler Asnes
,
Madeline Martin
,
Justin Svendsen
Keywords(s):
Category(s):
Medical Devices
,
Therapeutics
,
Materials Science
Anisotropic Poly(ethylene glycol)-Based Hydrogels Synthesized via Two-Stage Polymerization and Mechanical Alignment
1. Technology Overview The invention introduces synthetic poly(ethylene glycol)-based hydrogels with anisotropic polymer network topology, mimicking the structure of musculoskeletal tissues. These hydrogels are synthesized using a two-stage polymerization process, allowing for the application of mechanical force to impart anisotropy. The technology...
Published: 1/2/2026
|
Inventor(s):
Danielle Benoit
,
Tayler Hebner
Keywords(s):
Category(s):
Chemistry
,
Therapeutics
Engineering the Sodium/Iodide Symporter for Enhanced Targeted Internal Radiotherapy
Summary The Sodium/Iodide Symporter (NIS) is a critical protein that facilitates the active transport of iodide into thyroid cells, essential for synthesizing thyroid hormones. Recent advancements in engineering NIS variants aim to selectively transport oxyanions, offering innovative therapeutic strategies for cancer treatment in the thyroid and elsewhere...
Published: 12/18/2025
|
Inventor(s):
Keywords(s):
Category(s):
Therapeutics
Mental Health Functional Movement Scale (MH-FMS) (Case No. 2025-021)
Summary: UCLA researchers in the Department of Psychiatry and Behavioral Sciences have created a novel assessment platform that objectively measures how the brain, body, and autonomic nervous system respond to stress and regulate emotion during real-time movement. By integrating a shear-stress–based neurovascular framework with a polyvagal-informed...
Published: 12/17/2025
|
Inventor(s):
Naser Ahmadi
,
Mike Ramirez
,
Julien Pineau
Keywords(s):
blood flow management
,
Cardiovascular
,
cellular
,
clinical care methodology
,
clinical decision support
,
Clinical decision support system
,
clinical mental health
,
Clinical tool
,
exercise physiology
,
Hemodynamics
,
Mental health
,
neurobehavioral impairment
,
Neurocognitive
,
Neurocognitive Scientific Method
,
neurodevelopment
,
neurological disorders
,
Neuropsychological Test
,
neuroscience
,
Neurostimulation
,
Psychiatry / Mental Health
Category(s):
Diagnostic Markers
,
Life Science Research Tools
,
Medical Devices
,
Medical Devices > Hospital Systems
,
Therapeutics
,
Therapeutics
> Psychiatry And Mental Health
Novel Curcumin Derivatives with Enhanced Anti-Inflammatory Properties
SUMMARY This technology comprises two novel curcumin derivatives - compounds D3 and D4 - with potent anti-inflammatory properties. These compounds effectively inhibit a key inflammatory signaling pathway, offering enhanced therapeutic potential over traditional curcumin. The technology provides improved bioactive compounds for nutraceutical and pharmaceutical...
Published: 12/9/2025
|
Inventor(s):
Keywords(s):
Category(s):
Natural Products
,
Research Tools
,
Therapeutics
Genetic engineering approach for enhancing recombinant protein production by mammalian cells
Summary Vanderbilt researchers have developed a novel approach to enhance recombinant protein production in mammalian cell culture systems through metabolic engineering. By overexpressing specific metabolic proteins in these cells, this technology achieves higher monoclonal antibody titers and increased cell-specific productivity compared to conventional...
Published: 12/9/2025
|
Inventor(s):
Keywords(s):
Category(s):
Biomanufacturing
,
Research Tools
,
Therapeutics
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