Search Results - therapeutics

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Powerful Formulation for Respiratory Infection Prevention and Treatment
Description This technology is a set of innovative pharmaceutical formulations that utilize metabolites derived from specific gut microbiota to prevent respiratory infections and enhance immune health. Formulations are available for both oral and intranasal administration, offering flexibility and ease of use. By strengthening the immune system's...
Published: 5/14/2025   |   Inventor(s): Andrew Gewirtz, Vu Le Ngo
Keywords(s):  
Category(s): Therapeutics
Potent, Safer Respiratory Syncytial Virus Therapeutics
Description This technology is a cutting-edge antiviral technology designed to treat respiratory syncytial virus (RSV) by potently inhibiting RSV RNA synthesis. This technology has shown remarkable efficacy in preclinical mouse models, significantly reducing lung virus load. With the potential for oral administration and reduced toxicity, this breakthrough...
Published: 5/14/2025   |   Inventor(s): Richard Plemper, Julien Sourimant
Keywords(s):  
Category(s): Therapeutics
Methods of Electrode Configurations and Montages to Achieve Spatial Selectivity of Nerve Stimulation (Case No. 2024-277)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel method for spatially selective electrical nerve stimulation. Background: Peripheral nerve stimulation (PNS) is a common form of treatment for various ailments, such as chronic pain. This approach offers a non-pharmacological and minimally invasive option....
Published: 5/19/2025   |   Inventor(s): Jonathan Brand, Wentai Liu
Keywords(s): Consumer Electronics, Digital Electronics, Electrode, Electrode 3D Printing, electrodes, Electroencephalography (EEG), Flexible Electronics, Machine Learning Pain Management, Neuropsychological Test, Optoelectronics, Organic Electronics, Pain Treatment, Paint, Printed Electronics, Psychiatry / Mental Health, Psychology, Psychotherapy, soft electronics, Stretchable electrodes, tissue-electronic interface, wearable electronics
Category(s): Electrical, Electrical > Instrumentation, Electrical > Flexible Electronics, Medical Devices, Medical Devices > Neural Stimulation, Therapeutics, Therapeutics > Psychiatry And Mental Health
Highly Effective Nanobodies to Treat Henipavirus Infections
Description This technology is a series of small molecule therapeutics to treat Henipavirus infections, which is a dangerous group of viruses that cause severe diseases in both humans and animals. These nanobodies are engineered to recognize and bind to specific proteins on Nipah and Hendra viruses, effectively cross-neutralizing different strains...
Published: 4/8/2025   |   Inventor(s): Jianliang Xu
Keywords(s):  
Category(s): Therapeutics
Highly Effective Small Molecules for Cancer Treatment
Description This technology is a series of innovative small molecules demonstrating significant in-vitro anticancer activity. Isolated from a previously unstudied medicinal plant species, these compounds expand the potential of natural products in drug discovery. Previous studies on related plant species have identified compounds with a broad spectrum...
Published: 4/10/2025   |   Inventor(s): Paulos Yohannes, Binghe Wang
Keywords(s):  
Category(s): Therapeutics
Mechanical Cutaneous Nerve Stimulation for Reducing Epileptic Seizures and Perceived Pain (Case No. 2016-686-3)
Summary: UCLA researchers have developed a novel, non-invasive pain management device that uses mechanical vibrations to activate cutaneous sensory fibers, reducing epileptic seizures, masking pain perception and alleviating associated symptoms. Background: Unexpected death due to epilepsy is a pressing concern, with an estimated incidence of 1.2...
Published: 4/4/2025   |   Inventor(s): Ronald Harper, Eberhardt Sauerland, Christopher Degiorgio
Keywords(s): low-power device, Medical Device, Medical Devices and Materials, minimally invasive device, Neuropathology, Neurostimulation, non-invasive, Pain Treatment, sample-to-answer devices, Semiconductor Device, Smart medical device, Stroke, Transcutaneous Electrical Nerve Stimulation, Vibration monitoring, Vibration sensing, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > CNS and Neurology
First in class use of the estrogen receptor-b agonist in treating Angelman syndrome and relevant autism spectrum disorders
Overview Angelman syndrome is a genetic disorder caused by UBE3A gene dysfunction, leading to cognitive impairment, motor coordination issues, and developmental delays. Research suggests that oligodendroglial dysfunction, which affects myelination in the brain, contributes to these conditions. Based on the research, this invention discloses a novel...
Published: 3/17/2025   |   Inventor(s): Yu-Wen Huang, Xin Yang
Keywords(s):  
Category(s): Genetic Diseases, Therapeutics, Therapy Targets
A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)
Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...
Published: 3/27/2025   |   Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen
Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer
Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors
Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...
Published: 5/23/2025   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz
Keywords(s):  
Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular
Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke
Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...
Published: 4/8/2025   |   Inventor(s): Binghe Wang, Yueqin Zheng
Keywords(s):  
Category(s): Therapeutics, Research Tool
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