Search Results - therapeutics

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Compound Drug Delivery System (Case No. 2024-015)
Summary: Researchers in UCLA’s Department of Orthopaedic Surgery have developed novel multi-drug delivery system that is compatible with standard syringe-based administration routes. Background: Drug compounding is the process of combining two or more medications to meet the needs of individual patients. Surgeons may mix different anesthetics...
Published: 9/11/2024   |   Inventor(s): Fabrizio Billi, Mauricio Silva, Aaron Kavanaugh
Keywords(s):  
Category(s): Therapeutics, Platforms, Platforms > Drug Delivery, Medical Devices
Enhancing Methotrexate Efficacy for Ectopic Pregnancy Treatment
Methotrexate (MTX) loaded polymersomes are used to preferentially deliver MTX to sites of ectopic pregnancy Background Ectopic pregnancy, abnormal pregnancy implantation at sites other than in the uterine cavity, leads to internal bleeding if not identified and treated in a timely manner, and is a major cause of maternal morbidity and mortality....
Published: 9/5/2024   |   Inventor(s): Olena Taratula, Oleh Taratula, Maureen Baldwin, Leslie Myatt, Babak Mamnoon
Keywords(s):  
Category(s): Therapeutics
PD1+CD38+ CD8 T-cells, a marker for anti-PD1 therapy resistance and selection marker for treatment or continuation of treatment of patients, and a target to reverse resistance
PD1+CD38+ CD8 T-cells, a marker for anti-PD1 therapy resistance and selection marker for treatment or continuation of treatment of patients, and a target to reverse resistance Current state of the artA number of new checkpoint inhibitors are used in cancer therapy. PD-1 inhibitors such as Pembrolizumab (Keytruda), Nivolumab (Opdivo), and Cemiplimab...
Published: 8/29/2024   |   Inventor(s): Samir Khleif, Vivek Verma, Seema Gupta
Keywords(s):  
Category(s): Therapeutics
Combination therapy for the treatment of triple negative breast cancer
Summary Researchers at OHSU have discovered a novel combination therapy for triple negative breast cancer, which increases immune responses, causes tumor regression and improves survival in animal models. Technology Overview Triple negative breast cancer (TNBC) represents one of the most aggressive forms of all breast cancer subtypes with a very...
Published: 9/17/2024   |   Inventor(s): Sanjay Malhotra, Lisa Coussens, Dhanir Tailor, Sushil Kumar, Arpit Dheeraj
Keywords(s): Therapeutics, Therapeutics - Cancer
Category(s): Therapeutics
Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024   |   Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman
Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy
Surgical Mesh Permanent Implant (Case No. 2023-109)
Summary: UCLA Researchers in the Department of Chemistry and Biochemistry have developed a bacterial nanocellulose (BNC) that exhibits promising biocompatibility and mechanical properties that can be used as a long-term treatment for medical conditions requiring surgical mesh devices. Background: Surgical mesh devices are medical devices used to...
Published: 8/23/2024   |   Inventor(s): Paul Weiss, Melina Mastrodimos, Maryam Badv
Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, Implant (Medicine), Medical Device, Medical Devices and Materials, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Smart medical device, Surgical Instrument, surgical mesh, Surgical Tools, wearable medical device
Category(s): Medical Devices, Medical Devices > Surgical Tools, Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Gastroenterology, Therapeutics > Urology, Therapeutics > Transplant
Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)
Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...
Published: 8/15/2024   |   Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment
Zeolite Imidazole Framework-8 (Zif-8)-Based Osteoinductive and Inflammation-Inhibitory Coating for Dental Implants (Case No. 2023-141)
Summary: UCLA researchers from the School of Dentistry have developed zeolitic imidazolate framework-8 (ZIF-8) nanoparticles-based implant coating system for the controlled release of therapeutics. Background: One of the most significant advancements in clinical dentistry over the past four decades is the development of osteointegrated dental implants....
Published: 9/9/2024   |   Inventor(s): Alireza Moshaverinia, Weihao Yuan
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Dental, Medical Devices, Medical Devices > Coatings, Medical Devices > Surgical Tools, Materials
Portable, Lanyard Attachable Pill Popper Gadget (Case No. 2022-238)
Summary: UCLA researchers from the Department of Orthopedic Surgery have developed a portable gadget for handling medical packaging in the healthcare space. Background: Healthcare workers operate in a dynamic environment where they use a variety of medical supplies including gauze pads, pills, and face masks. Disposable supplies can be packaged...
Published: 6/4/2024   |   Inventor(s): Veronica Pellegrino
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > Medication, Materials, Materials > Functional Materials
Antibodies against CD5L for therapeutic and diagnostic uses
Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...
Published: 5/28/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Anil Sood
Keywords(s):  
Category(s): Biologics, Oncology, Therapeutics
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