Search Results - hematology

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Collagen IV binding Vascular Endothelial Growth Factor (VEGF) Bioconjugates for Vascularization
NU2022-150 INVENTORS Kyle M. Koss* Yangxi Liu Jason A. Wertheim* SHORT DESCRIPTION Bioconjugates that localize and concentrate VEGF within scaffold structures to support long-term cell survival and promote vascularization in tissue engineering applications BACKGROUND The development of effective vascularization strategies is crucial for...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Hematology, Neurology
Category(s): Life Sciences > Therapeutics
Single-Chain Bispecific Chimeric Antigen Receptor Targeting BCMA and CS1 for the Treatment of Multiple Myeloma (UCLA Case No. 2018-680)
UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a single-chain bispecific chimeric antigen receptor targeting BCMA and CS1 for treating multiple myeloma. BACKGROUND: Multiple myeloma (MM) is a cancer of the plasma cells that accounts for over 30,000 new diagnoses each year, according to the American Cancer...
Published: 7/31/2025   |   Inventor(s): Yvonne Chen, Eugenia Zah
Keywords(s): Hematology, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Therapeutics > Immunology And Immunotherapy, Therapeutics > Hematology
Alleviating GvHD Using Engineered INKT Cells (UCLA Case No. 2023-019)
SUMMARY: Researchers in UCLA’s Department of Microbiology, Immunology & Molecular Genetics have developed an off-the-shelf cell therapy method for reduction of Graft vs Host Disease (GvHD) following hematopoietic stem cell transplantation. This approach uses engineered third-party iNKT’s to ameliorate severity of GvHD without negatively...
Published: 7/31/2025   |   Inventor(s): Lili Yang
Keywords(s): Hematology, Stem-Cell Therapy, T Cell, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Hematology
2019-870 GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM CELLS (XHIM)
Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells. BACKGROUND:Hematopoietic stem cells (HSCs)—stem cells that give rise to...
Published: 7/17/2025   |   Inventor(s): Donald Kohn
Keywords(s): Gene Editing Systems, Gene Therapy, Genetic Disease, Hematology, Immunotherapy, iPS/stem cells, Therapeutics & Vaccines, Viral Delivery Systems
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
2013-741 Bioengineered Thymic Aggregates for Implantation
Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...
Published: 2/14/2025   |   Inventor(s): Gay Crooks, Amelie Montel-Hagen, Brile Chung
Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy
2012-184 Computer-Driven Hemodynamics Simulation
Computer-Driven Hemodynamics SimulatorSUMMARYResearchers in the Division of Cardiothoracic Surgery at UCLA have developed a computer-based, reconfigurable hemodynamic simulation program for realistic medical training.BACKGROUNDSimulation training in surgery and critical care is a part of the mandated training programs for medical professionals to teach...
Published: 2/14/2025   |   Inventor(s): Peyman Benharash, Paul Frank
Keywords(s): Education, Hematology, Software, Software & Algorithms
Category(s): Software & Algorithms, Therapeutics > Hematology, Software & Algorithms > Programs
2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration
Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...
Published: 7/17/2025   |   Inventor(s): John Chute, Michael Jung, Emelyne Diers
Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology
Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
2016-694 INHIBITION OF THE AGGREGATION OF TRANSTHYRETIN BY SPECIFIC BINDING OF PEPTIDES TO AGGREGATION-DRIVING SEGMENTS
Inhibition of the Aggregation of Transthyretin by Specific Binding of Peptides to Aggregation-Driving SegmentsSUMMARYUCLA researchers from the Department of Chemistry and Biochemistry have developed a novel process to inhibit amyloid aggregation of Transthyretin, which is associated with three debilitating disorders including senile systemic amyloidosis...
Published: 7/17/2025   |   Inventor(s): David Eisenberg, Lorena Saelices Gomez
Keywords(s): Cardiovascular, Cns, Genetic Disease, Hematology, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Hematology, Therapeutics > CNS and Neurology
2015-365 TARGETING PROTEIN TYROSINE PHOSPHATASE-SIGMA TO AUGMENT HEMATOPOIETIC RECONSTITUTION
Targeting Protein Tyrosine Phosphatase-Sigma to Augment Hematopoietic ReconstitutionSUMMARYUCLA researchers from the Department of Medicine have developed a novel technique for inducing increased hematopoietic recovery after HSC transplantation by targeting the protein tyrosine phosphatase-sigma (PTP-sigma) pathway.BACKGROUNDReceptor tyrosine kinases...
Published: 7/17/2025   |   Inventor(s): John Chute
Keywords(s): Hematology, Life Science Research Tools, Targets And Assays, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Hematology
Gene Repair for Hemophilia A (UCLA Case No. 2014-016)
Gene Repair For Hemophilia ASUMMARYResearchers at UCLA from the Departments of Medicine and Urology have developed a treatment for hemophilia A that utilizes non-viral gene editing technologies for ex vivo repair of the mutation in the gene F8.BACKGROUNDHemophilia affects about 400,000 people worldwide, and approximately 80% of these cases are hemophilia...
Published: 7/17/2025   |   Inventor(s): Thomas Howard, Vincent La Terza
Keywords(s): Gene Therapy, Hematology, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Hematology, Therapeutics > Gene Therapy And Editing
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