Search Results - autoimmune+disease

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Analytical Device for Sorting Single Cells Based on Secreted Products
NU 2023-084 INVENTORS Shana O. Kelley* Zongjie Wang Mahmoud A. M. Labib SHORT DESCRIPTION A high-throughput, cost-effective device for sorting of single cells in a culture and analysis of their secreted products. BACKGROUND The demand for cost-effective cell analysis methods is expanding due to the increasing urge for the early detection,...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biomedical, Devices, Diagnostics, Drug screening, Personalized medicine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Genetically Modified Hematopoietic Stem And Progenitor Cells (HSPCs) And Mesenchymal Cells As A Platform To Reduce Or Prevent Metastasis, Treat Autoimmune And Inflammatory Disorders, And Rebalance The Immune Milieu And Dysregulated Niches
Abstract: Cancer cells can spread to various regions in the body in a process called metastasis which is associated with non-responsive to treatment and thus reduced survival. Identifying the markers of metastasis has been a major concern in the field of cancer diagnosis and therapy. Interestingly, research has shown that there is an increase in myeloid...
Published: 4/8/2024   |   Inventor(s): Rosandra Kaplan, Sabina Kratzmeier, Daneil Beury, Haiying Qin
Keywords(s): adoptive cell therapy, AUTOIMMUNE DISEASE, Cancer Immunotherapy, GEMys, Genetically Engineered Myeloid Cells, Kaplan, Metastasis, Platform Technology
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...
Published: 9/24/2024   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
Glucocorticoid-induced TNFR Family-Related Receptor Ligand (GITRL) Antibodies for Diagnosis and Treatment of Immune System Disorders
This technology provides novel antibodies and methods for diagnostics and treatment of disorders arising from dysregulation of the immune system using antibodies directed against glucocorticoid-induced tumor necrosis factor receptor family-related receptor ligand (GITRL). Also available are hybridomas producing anti-mouse GITRL monoclonal antibodies...
Published: 7/25/2024   |   Inventor(s): Ethan Shevach
Keywords(s): antibodies, AUTOIMMUNE DISEASE, CD25, CD4, GITR, GITRL, IB3XXX, IBXXXX, IDXXXX, immune response, immune suppressor, IXXXXX, Multiple sclerosis, Patent Category - Biotechnology, RHEUMATOID ARTHRITIS, T cell, Treg
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
2022-084 HUMAN LEUKOCYTE ANTIGEN HAPLOTYPE ANALYSIS TOOLKIT (HLA-HAT)
SUMMARY: UCLA researchers in the department of Medicine, Hematology and Oncology have developed software which facilitates the clinically relevant investigation of genetic antigen heterogeneity within human leukocytes BACKGROUND: Human leukocyte antigen system is a critical component of the immune system. A major part of this is a series of genes...
Published: 9/19/2024   |   Inventor(s): Katie Campbell
Keywords(s): Algorithm, Allele, Autoimmune Disease, Bioinformatics, Biotechnology, CD3 (Immunology) Human Leukocyte Antigen, Functional Genomics, Genetic Algorithm, Genetic Testing, Immunology, Inflammation, Instrumentation & Analysis, Sequencing, Software, Software & Algorithms
Category(s): Life Science Research Tools, Software & Algorithms, Software & Algorithms > Bioinformatics
Strategy to Isolate Regulatory T Cells Capable of Inducing Robust Immunoregulation
Utilizes Cell-Surface Markers to Isolate and Manipulate Treg Cells during Treatment and Prevention of Autoimmune and Inflammation-Mediated DiseasesThis strategy enables the isolation of a potent population of regulatory T cells for autoimmune disease treatment by identifying specific surface markers characteristic of this cell population. The National...
Published: 12/7/2021   |   Inventor(s): Christopher Fuhrman, Todd Brusko
Keywords(s): Autoimmune disease, CD226, makers, Regulatory T Cells, Target, TIGIT
Category(s): Technology Classifications > Human Health Care > Therapeutics
POP3, a Novel Inflammasome Inhibitor and its Use Of
NU 2010-160 Inventors Christian Stehlik Short DescriptionPOP3 protein as a method to modulate inflammationAbstract Northwestern researchers have identified a new member of the PYD-only protein (POPs) family (POP3) as a specific regulator of ALR inflammasomes, promoting IFN-beta production and reducing IL-1beta and IL-8 production. POP3 has the potential...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Autoimmune disease, Infectious disease, Inflammation, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeted Enhancement of CD154 Trimer Stability for Modulation of Immune Function
NU 2005-008 InventorsLaurence Howard John Irwin Stephen Miller* Brian Shoichet AbstractRegulating immune cell response is critical in combating disease. Northwestern researchers have developed a new therapy that can either inhibit immune cell function in autoimmune disease or enhance natural or vaccine-facilitated immune responses. A small molecule...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Autoimmune disease, Cancer/Oncology, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics