Search Results - autoimmune+disease

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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU 2025-212 IP STATUS US...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Synthetic Receptors for IL-23
NU 2024-093 SHORT DESCRIPTION Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions. INVENTORS Joshua Leonard* McCormick School of Engineering, Department of Chemical and Biological Engineering Aaron Morris William...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
NU 2024-047 SHORT DESCRIPTION An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares. INVENTORS Arthur Prindle* McCormick School of Engineering, Department of Chemical and Biological Engineering Jonathan...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
Wireless, Miniaturized Sensing Platforms for Inflammatory Bowel Diseases
­LUNU 2023-223 INVENTORS John Rogers* Arun Sharma* Surabhi Madhvapathy Matthew Bury SHORT DESCRIPTION Miniaturized, implantable temperature sensors for real-time, minimally invasive monitoring of inflammatory bowel diseases. BACKGROUND Inflammatory Bowel Disease (IBD), encompassing Crohn’s disease and ulcerative colitis, affects over 10...
Published: 12/22/2025   |   Updated: 5/8/2025   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biomedical, Biotechnology, Devices, Diagnostics, Electronics & Circuits, Gastrointestinal and Hepatic disease, Healthcare, Medical device, Obesity, Sensors, Wireless
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Analytical Device for Sorting Single Cells Based on Secreted Products
NU 2023-084 INVENTORS Shana O. Kelley* Zongjie Wang Mahmoud A. M. Labib SHORT DESCRIPTION A high-throughput, cost-effective device for sorting of single cells in a culture and analysis of their secreted products. BACKGROUND The demand for cost-effective cell analysis methods is expanding due to the increasing urge for the early detection,...
Published: 11/6/2025   |   Updated: 2/1/2024   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biomedical, Devices, Diagnostics, Drug screening, Personalized medicine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Genetically Modified Hematopoietic Stem And Progenitor Cells (HSPCs) And Mesenchymal Cells As A Platform To Reduce Or Prevent Metastasis, Treat Autoimmune And Inflammatory Disorders, And Rebalance The Immune Milieu And Dysregulated Niches
Abstract: Cancer cells can spread to various regions in the body in a process called metastasis which is associated with non-responsive to treatment and thus reduced survival. Identifying the markers of metastasis has been a major concern in the field of cancer diagnosis and therapy. Interestingly, research has shown that there is an increase in myeloid...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Rosandra Kaplan, Sabina Kratzmeier, Daneil Beury, Haiying Qin
Keywords(s): adoptive cell therapy, AUTOIMMUNE DISEASE, Cancer Immunotherapy, GEMys, Genetically Engineered Myeloid Cells, Kaplan, Metastasis, Platform Technology
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Glucocorticoid-induced TNFR Family-Related Receptor Ligand (GITRL) Antibodies for Diagnosis and Treatment of Immune System Disorders
This technology provides novel antibodies and methods for diagnostics and treatment of disorders arising from dysregulation of the immune system using antibodies directed against glucocorticoid-induced tumor necrosis factor receptor family-related receptor ligand (GITRL). Also available are hybridomas producing anti-mouse GITRL monoclonal antibodies...
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Ethan Shevach
Keywords(s): antibodies, AUTOIMMUNE DISEASE, CD25, CD4, GITR, GITRL, IB3XXX, IBXXXX, IDXXXX, immune response, immune suppressor, IXXXXX, Multiple sclerosis, Patent Category - Biotechnology, RHEUMATOID ARTHRITIS, T cell, Treg
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
Muramyl Dipeptide as a Therapeutic Agent for Inflammation
The nucleotide-binding oligomerization domain 2 (NOD2) protein plays a key role in innate immunity as a sensor of muramyl dipeptide (MDP), a breakdown product of bacterial peptidoglycan. Bacterial peptidoglycan promotes the innate immune response through the activation of Toll-like receptor 2 (TLR2), which ultimately provokes inflammation. Activation...
Published: 3/26/2026   |   Updated: 12/6/2022   |   Inventor(s): Warren Strober
Keywords(s): Autoimmune, AUTOIMMUNE DISEASE, Autoimmune disorder, Autoimmunity, BBXXXX, BCXXXX, BOWEL, Crohn disease; Inflammatory bowel disease 1, Crohn's disease, Dipeptide, IB3XXX, IBD, IBXXXX, IL-12, Inflammation, INFLAMMATORY, inflammatory bowel disease, Inflammatory bowel disease 1, inflammatory disease, INTERLEUKIN, INTERLEUKIN-12, IRF4, IXXXXX, MDP, Muramyl, NOD2, peptidoglycan, TLR, TLR2, Toll-like, Toll-like receptors, Ulcerative Colitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics
Immunomodulatory Nanoparticles for the Therapeutic Intervention of Traumatic Brain Injury
NU 2019-030 INVENTORS John Kessler Sripadh Sharma ABSTRACT There is no decisive treatment for traumatic brain injury (TBI). After the primary trauma, secondary injury, largely mediated by blood-borne immune cells called monocytes, takes place causing damage to surrounding healthy cells. Furthermore, cellular and whole brain swelling (edema) resulting...
Published: 1/14/2026   |   Updated: 5/27/2022   |   Inventor(s):  
Keywords(s): Autoimmune disease, CNS - Central Nervous System, Immunology, Inflammation, Neurologic disease, Neurology, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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