Search Results - cell+therapy

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T-Cell-Activating Lipid Nanoparticles for Rapid Engineering of CAR T Cells
A method to streamline the process of generating chimeric antigen receptor (CAR) T cells for therapeutic applications. Problem: CAR T cell therapy has demonstrated clinical success in treating various forms of cancer. With more CAR T cell therapies projected to gain regulatory approval, manufacturing becomes increasingly important in the face of this...
Published: 12/20/2024   |   Inventor(s): Ann Metzloff, Margaret Billingsley, Michael Mitchell
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Method to Alleviate Side Effects of CAR T Cell Immunotherapies
CAR-T cells are PEGylated to block the interactions with monocytes and macrophages to reduce the side effects of CAR-T cell therapies (cytokine release syndrome and neurotoxicity). Problem: CAR-T cell therapies lead to many adverse side effects such as cytokine release syndrome (CRS) and neurotoxicity. It has been shown that 20-70% of patients receiving...
Published: 12/20/2024   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Safe and Potent mRNA Lipid Nanoparticles (LNPs) for Ex-Vivo Engineering of Immunosuppressive T cells in Autoimmunity Therapies.
Using mRNA-LNPs to deliver forkhead box protein 3 (Foxp3) to CD4+ T cells to engineer Foxp3-positive T (FP3T) cells with immunosuppressive properties. Problem: Autoimmune disorders (e.g., type 1 diabetes, multiple sclerosis, and myasthenia gravis) are mediated by self-reactive lymphocyte (B or T cells) expansion. Available suppressive medications like...
Published: 10/1/2024   |   Inventor(s): Michael Mitchell, Ajay Thatte, Alvin Mukalel
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Immunology, Immunotherapy, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Tumor Suppression by Retinoic Acid Pathway Inhibition
­Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024   |   Inventor(s): Malay Haldar, Ganesha Rai Bantukallu
Keywords(s): Cell Therapy, Drug Target, Immunology, Immunoncology, Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Treating Prostate Cancer with Novel Sugar-Antigen-Targeting CAR-T Cells
Problem: While the 5-year relative survival rate for patients with local or regional prostate cancer is nearly 100%, the 5-year relative survival rate drops to 32% for patients with metastatic or advanced disease. These patients may initially respond to available therapies, but most patients will develop therapy resistance and succumb to disease. Solution: A...
Published: 6/20/2024   |   Inventor(s): Mark Greene, Michael Milone
Keywords(s): Cell Therapy, Oncology
Category(s): Technology Classifications > Therapeutics
Induced Pluripotent Stem Cells Derived from Patients with CEP290-associated Ciliopathies and Unaffected Family Members
Abstract: Approximately one-third of non-syndromic retinal dystrophies involve a defect in a ciliary protein. Non-syndromic retinal ciliopathies include retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, macular dystrophy, and Leber-congenital amaurosis (LCA). Many CEP290-LCA patients also exhibit auditory and olfactory defects. Induced pluripotent...
Published: 12/6/2024   |   Inventor(s): Anand Swaroop, Hiroko Shimada-Ishii, Yu Holly Chen, Milton English
Keywords(s): Anosmia, Cell therapy, Ciliopathies, Congenital Blindness, Drug Development, GENE THERAPY, hearing loss, iPS, National Eye Institute, NEI, Pluripotent Stem Cells, Primary Cilia, Retina, Retinal degeneration, Swaroop, VISION
Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
3D Vascularized Human Ocular Tissue for Cell Therapy and Drug Discovery
Abstract: Degeneration of retinal tissues occurs in many ocular disorders resulting in the loss of vision. Dysfunction and/or loss of Retinal Pigment Epithelium Cells (RPE) and disruption of the associated blood retinal barrier (BRB) tissue structures are linked with many ocular diseases and conditions including: age-related macular degeneration (AMD),...
Published: 12/6/2024   |   Inventor(s): Kapil Bharti, Min Jae Song, Russell Quinn
Keywords(s): 3D bio-printing, Bharti, Blood Retinal Barrier Disorder, BRB, Cell therapy, in Vitro Human Blood Retinal Barrier Model, Ocular cell therapy scaffold, Retinal disorder, Retinal Pigment Epithelium Cells
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
Devices for Improved Tissue Cryopreservation and Recovery
Abstract: Problem: Cryopreservation is a process where living biological materials like cells, tissues, and cell therapies (which are susceptible to damage caused by unregulated chemical kinetics) are preserved by cooling to very low temperatures in the presence of specific cryopreservation media that protects the biological material from damage. In...
Published: 12/6/2024   |   Inventor(s): Vladimir Khristov, Arvydas Maminishkis, Kapil Bharti
Keywords(s): Cell recovery, Cell thawing, Cell therapy, Cryopreservation, Defrost, National Eye Institute, NEI, Tissue transplant
Category(s): Collaboration Sought > Materials Available, Application > Medical Devices, TherapeuticArea > Immunology, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Non-Medical Devices, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
Machine Learning and/or Neural Networks to Validate Stem Cells and Their Derivatives for Use in Cell Therapy, Drug Delivery, and Diagnostics
Abstract: Many biological and clinical procedures require functional validation of a desired cell type. Current techniques to validate rely on various assays and methods, such as staining with dyes, antibodies, and nucleic acid probes, to assess stem cell health, death, proliferation, and functionality. These techniques potentially destroy stem cells...
Published: 4/8/2024   |   Inventor(s): Kapil Bharti, Nicholas Schaub, Carl Simon, Nathan Hotaling
Keywords(s): Bharti, Cell therapy, Cell Validation, Less Invasive Diagnostics, Machine Learning, Neural Networks, QUALITY CONTROL, Stem Cell Diagnostics, Stem Cell Therapy
Category(s): TherapeuticArea > Cardiology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Software / Apps, TherapeuticArea > Dermatology
Methods for Cryopreservation of Cells for Improved Commercial Manufacture of NK Cell Therapies
A method that maintains the viability and function of NK cells following cryopreservation, enabling the production, storage, and transportation of therapeutic doses of NK cells to treatment centers. Problem: There is a growing interest in using NK cells as immunotherapies for diseases such as cancer. Making commercially viable NK cell therapies requires...
Published: 10/16/2023   |   Inventor(s): Neil Sheppard, Abdulla Berjis
Keywords(s): Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
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