Search Results - juntao+luo

12 Results

Sort By:

Bioactive Telodendrimer Nanocarrier for Antibiotics Delivery and Immune Modulation

Novel telodendrimer nanoparticles have been developed to enhance the delivery and safety profile of the antibiotic Polymyxin B by improving its stability and reducing toxicity during treatment. Background: Polymyxin B (PMB) is a powerful antibiotic used to treat infections caused by Gram-negative bacteria, but its clinical application is limited...

Published: 6/12/2026 | Updated: 6/12/2026 | Inventor(s): Juntao Luo, Dandan Guo, Md Shanewaz Hossan, Changying Shi

Keywords(s): Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Development of novel liver-targeting glucocorticoid prodrugs

This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects. Background: Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Hong Lu, Juntao Luo, Dandan Guo

Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Metal organic framework membranes for ion transport and separation

Background Ion-selective separation membranes play a critical role in applications such as water purification, energy storage, and chemical processing. These technologies are essential for tackling global challenges like clean water scarcity, efficient energy utilization, and sustainable industrial processes. Traditional ion separation methods,...

Published: 5/12/2026 | Updated: 12/3/2025 | Inventor(s): Huacheng Zhang, Xingya Li, Huanting Wang, Jun Lu, Anita Hill, Benny Freeman

Keywords(s):

Category(s): Physical sciences > Materials > Membranes

Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery

A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity. Background: Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...

Published: 1/29/2026 | Updated: 5/13/2025 | Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi

Keywords(s): Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines

Injectable Nanogel for Immune Modulation Therapy

A platform for effective therapeutic delivery and immune modulation for effective and quick inflammation control in critical illness, including sepsis. Background: Immune modulation therapy is a type of immunotherapy that enhances the body’s immune regulation and homeostasis. This therapy has proved promising for the treatment of some types...

Published: 1/30/2026 | Updated: 5/13/2025 | Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi

Keywords(s): Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion

This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice. Background: The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...

Published: 1/30/2026 | Updated: 5/13/2025 | Inventor(s): Juntao Luo, Lili Wang, Changying Shi

Keywords(s):

Category(s): Campus > Upstate Medical University, Technology Classifications > Nanotechnology

Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments

A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...

Published: 6/12/2026 | Updated: 5/13/2025 | Inventor(s): Juntao Luo, Dandan Guo, Changying Shi

Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E

Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University

Novel Nanocarrier for Systemic and Intracellular Delivery of Biological Therapeutics

Novel nanocarrier for systemic and intracellular delivery of biological therapeutics. Background: The stability and PK profile are of general concern for in vivo applications of many peptide/protein therapeutics. Poor stability of protein drugs can trigger immunogenicity. Furthermore, peptide and protein therapeutics mostly target extracellular receptors/signaling...

Published: 6/12/2026 | Updated: 5/13/2025 | Inventor(s): Juntao Luo, Changying Shi, Lili Wang

Keywords(s):

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Telodendrimer Nanoparticles for Protein Delivery

A nanoparticle-based method for enhanced delivery of protein/peptide therapeutics. Background: Biologics, for example protein and peptide-based therapeutics, have poor in vitro shelf stability and in vivo enzymatic stability, which lead to short blood circulating time and contribute to immunogenicity. In addition, biologics are impermeable to biological...

Published: 6/12/2026 | Updated: 5/13/2025 | Inventor(s): Juntao Luo, Xu Wang, Changying Shi, Alexa Bodman, Walter Hall

Keywords(s): cancer therapy, lipidoids, nanoparticles, protein delivery, telodendrimers

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Nanotechnology

Reducing Oxidative Stress with Multifunctional Radical Quenchers

Mitochondria are intracellular organelles responsible for a number of metabolic transformations and regulatory functions. They produce much of the ATP employed by eukaryotic cells. They are also the major source of free radicals and reactive oxygen species that cause oxidative stress. Mitochondrial defects are damaging, particularly to neural and...

Published: 2/26/2026 | Updated: 12/27/2023 | Inventor(s): Sidney Hecht, Jeffrey Armstrong, Omar Khdour, Jun Lu, Pablo Arce

Keywords(s): Therapeutics

Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics

1 2