Search Results - brain+cancer

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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU 2025-212 IP...
Published: 4/29/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160 INVENTORS Jason Miska* Feinberg School of Medicine, Department of Neurological Surgery Peng Zhang* Feinberg School of Medicine, Department of Neurological Surgery SHORT DESCRIPTION Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM. BACKGROUND Glioblastoma...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
SEC61 Complex as a Novel Therapeutic Target to Enhance Immunotherapy Response in Glioblastoma
NU 2023-011 INVENTORS Irina Balyasnikova* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Joseph Duffy SHORT DESCRIPTION A targeted therapeutic approach that inhibits the SEC61 complex to enhance responses to immunotherapy in glioblastoma. BACKGROUND Glioblastoma (GBM) is the most aggressive primary...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Cancer/Oncology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
NU 2022-151 SHORT DESCRIPTION A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist. INVENTORS Maciej Lesniak* Northwestern University Feinberg...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeting EGFR Co-Amplified Long-Noncoding RNA for Glioblastoma Treatment
NU 2025-335 INVENTORS Shi-Yuan Cheng* Xiaozhou Yu Bo Hu Runxin Wu Xiao Song SHORT DESCRIPTION This invention provides compositions and methods for inhibiting ELDR and HELDR, two long non-coding RNAs (lncRNAs) that are frequently co-amplified in glioblastoma (GBM) with the epidermal growth factor receptor (EGFR) gene, and which drive tumorigenesis...
Published: 3/30/2026   |   Updated: 3/30/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Cancer Treatment, Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
Bioelectric Neuromodulation Methods for Hematopoiesis Regulation During Chemotherapy (Case No. 2020-382)
Summary: UCLA researchers in the Department of Bioengineering have developed an electrical neuromodulation method to accelerate recovery from deleterious chemotherapy side effects to improve patient outcome. Background: Chemotherapy works by targeting and killing fast-growing cancer cells using anti-cancer drugs. However, because these drugs lack...
Published: 10/21/2025   |   Updated: 8/21/2025   |   Inventor(s): Wentai Liu
Keywords(s): algorithmic cancer detection, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, cancer inhibition, cancer metabolism, Cancer stem cells, cancer target, castration resistant prostate cancer, Chemotherapy, head and neck cancer, lympathic cancers, lymphatic cancer, Mesenchymal Stem Cell Derived Cancer Cells, Neuromodulation, non-small cell lung cancer, Orthotopic cancer models, Pancreatic cancer, prostate cancer, small cell cancer, small cell lung cancer, small cell prostate cancer
Category(s): Medical Devices, Medical Devices > Neural Stimulation, Chemical, Electrical, Therapeutics, Therapeutics > Oncology
Anti-CD73 Monoclonal Antibody for Enhanced Cancer Immunotherapy
NU 2020-207 INVENTORS Bin Zhang* Siqi Chen Jie Fan SHORT DESCRIPTION This invention comprises novel anti-CD73 monoclonal antibody compositions that recognize and inhibit mouse and human CD73. BACKGROUND CD73, an ecto-enzyme associated with adenosine metabolism, is an emerging immune checkpoint that promotes tumor progression by suppressing...
Published: 12/11/2025   |   Updated: 1/30/2025   |   Inventor(s):  
Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Colon cancer, Gastric cancer, Immunotherapy, Lung cancer, Ovarian cancer, Pancreatic cancer, Therapeutics
Category(s): Life Sciences > Therapeutics
CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074 INVENTORS Irina V. Balyasnikova* BACKGROUND Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME)...
Published: 4/9/2026   |   Updated: 10/17/2024   |   Inventor(s):  
Keywords(s): Brain cancer, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Human Glioblastoma Model (UCLA Case No. 2023-273/2024-151)
UCLA researchers in the Department of Biological Chemistry have developed a novel method to study glioblastoma using human brain organoids. BACKGROUND: The National Institutes of Health defines glioblastoma as the most malignant and pervasive subtype of glioma, or glial-based cancer, and report that it is the most common primary brain tumor in adults....
Published: 11/21/2025   |   Updated: 6/18/2024   |   Inventor(s): Aparna Bhaduri
Keywords(s): Brain cancer, Brain organoid, Brain Tumor, Cancer, Glioblastoma, Organoids
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Oncology
Synthetic Lethality of IR with ABBV-155 in Glioblastoma (GBM) (UCLA Case No. 2021-232)
UCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that irradiation therapy can be combined with an antibody drug conjugate to form a novel therapeutic strategy to treat and extend survival of glioblastoma patients. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain...
Published: 7/17/2025   |   Updated: 6/18/2024   |   Inventor(s): David Nathanson
Keywords(s): Antibody-Drug Conjugate, Apoptosis, Brain cancer, Cancer, Glioblastoma, irradiation
Category(s): Therapeutics > Oncology
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