Search Results - synthetic+biology

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Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178 INVENTORS Neha Kamat* Joshua Leonard* Justin Alexander Peruzzi Taylor Gunnels SHORT DESCRIPTION This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery. BACKGROUND Extracellular...
Published: 2/28/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231 INVENTORS Neha Kamat* Justin Alexander Peruzzi Jan Steinkuehler SHORT DESCRIPTION This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems. BACKGROUND Spatially...
Published: 2/28/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
Synthetic Exosomes (SE) for CNS Delivery of CRISPR for Gene Editing in Brain Disorders (UCLA Case No. 2021-363)
UCLA researchers from the Department of Neurology have developed synthetic exosomes, a novel delivery technology capable of transporting gene-editing tools and therapeutics across the blood-brain barrier, with successful applications in repairing Alzheimer’s-related mutations and delivering proteins, antibodies, and drugs. BACKGROUND: The emergence...
Published: 2/18/2025   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, CRISPR, delivery system, exosome, Nanotechnology, nanovesicles, synthetic biology
Category(s): Life Science Research Tools > Microfluidics And Mems, Materials > Nanotechnology, Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Therapeutics > CNS and Neurology
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU2024-139 INVENTORS Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Sam Lobo Peter C. Ryffel Songi Han* SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau fibrils. BACKGROUND A major hallmark of several neurodegenerative...
Published: 3/3/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Research tool, Synthetic biology
Category(s): Life Sciences > Therapeutics
Modular Extracellular Sensors for Cell-based Biosensors
NU 2011-109BInventorsJoshua Leonard*Rachel Dudek Nichole Daringer Short DescriptionEngineered receptors designed to control gene expression BackgroundEngineering mammalian cell-based devices that monitor and therapeutically modulate human physiology is a promising and emerging frontier in clinical synthetic biology. However, realizing this vision required...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Animal Model, Diagnostics, Research tool, Sensors, Synthetic biology, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools