Search Results - synthetic+biology

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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares. INVENTORS Arthur Prindle* McCormick School of Engineering, Department of Chemical and Biological Engineering Jonathan...
Published: 4/30/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
Methods for Building RNA Organelles in Vitro (UCLA Case No. 2023-286)
UCLA researchers from the Department of Bioengineering have developed artificial RNA sequences that can form condensates in vitro, allowing customization of cellular function in membrane-less organelles. BACKGROUND: RNA condensates are intracellular membrane-less compartments formed by phase separation, involving RNA and proteins. These RNA condensates...
Published: 7/17/2025   |   Updated: 5/12/2025   |   Inventor(s): Elisa Franco
Keywords(s): Nanotechnology, RNA, synthetic biology
Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Plasmids/Vectors
Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178 INVENTORS Neha Kamat* Joshua Leonard* Justin Alexander Peruzzi Taylor Gunnels SHORT DESCRIPTION This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery. BACKGROUND Extracellular...
Published: 4/13/2026   |   Updated: 2/28/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231 INVENTORS Neha Kamat* Justin Alexander Peruzzi Jan Steinkuehler SHORT DESCRIPTION This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems. BACKGROUND Spatially...
Published: 4/9/2026   |   Updated: 2/28/2025   |   Inventor(s):  
Keywords(s): Drug delivery, Nanomaterials, Nanoparticle, Nanotechnology, Research tool, Synthetic biology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
Synthetic Exosomes (SE) for CNS Delivery of CRISPR for Gene Editing in Brain Disorders (UCLA Case No. 2021-363)
UCLA researchers from the Department of Neurology have developed synthetic exosomes, a novel delivery technology capable of transporting gene-editing tools and therapeutics across the blood-brain barrier, with successful applications in repairing Alzheimer’s-related mutations and delivering proteins, antibodies, and drugs. BACKGROUND: The emergence...
Published: 7/17/2025   |   Updated: 2/18/2025   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, CRISPR, delivery system, exosome, Nanotechnology, nanovesicles, synthetic biology
Category(s): Life Science Research Tools > Microfluidics And Mems, Materials > Nanotechnology, Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Therapeutics > CNS and Neurology
Genetic circuits for engineering hypoxia-responsive cellular functions
NU 2021-259 INVENTORS Joshua Leonard* Patrick Donahue SHORT DESCRIPTION A customizable DNA based biosensor for detecting hypoxic environments BACKGROUND Cell-based therapies have been successful in treating many malignancies, leading to substantial increases in patient survival. However, translating these successes to the treatment of solid...
Published: 4/9/2026   |   Updated: 1/28/2025   |   Inventor(s):  
Keywords(s): Biosensors, Cancer/Oncology, CVA - Cerebrovascular Accident, Regenerative medicine, Research tool, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Membrane Encapsulation of a Transcriptionally Regulated Cell-Free Biosensor
NU 2022-162 INVENTORS Neha P. Kamat* Julius B. Lucks* Margrethe Boyd Walter M. Thavarajah BACKGROUND Cell-free systems allow biochemical processes traditionally performed by cells to be reproduced independent of cells in a cost-effective, distributable, and highly tunable manner. Specifically, cell-free biosensors have enabled...
Published: 4/13/2026   |   Updated: 10/17/2024   |   Inventor(s):  
Keywords(s): Biosensors, Nanoparticle, Nanotechnology, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
NU 2022-192 INVENTORS Neha P. Kamat* Vivian Hu BACKGROUND Virus infection posts a recurring global health challenge, and vaccines remain an effective protective against virus threats. However, many current vaccines face limitations including potential conversion of inactivated virus into pathogenic virus, immunogenicity of recombinant...
Published: 4/10/2026   |   Updated: 10/17/2024   |   Inventor(s):  
Keywords(s): Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Modular Extracellular Sensors for Cell-based Biosensors
NU 2011-109BInventorsJoshua Leonard*Rachel Dudek Nichole Daringer Short DescriptionEngineered receptors designed to control gene expression BackgroundEngineering mammalian cell-based devices that monitor and therapeutically modulate human physiology is a promising and emerging frontier in clinical synthetic biology. However, realizing this vision required...
Published: 11/6/2025   |   Updated: 10/14/2019   |   Inventor(s):  
Keywords(s): Animal Model, Diagnostics, Research tool, Sensors, Synthetic biology, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools