Search Results - autoimmune

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A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)
Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...
Published: 1/24/2024   |   Inventor(s): Rhonda Voskuhl, Michael Jung
Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics
BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
­BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS Researchers at Stanford have developed a new avenue for stimulating T effector and Treg immune cells in an antigen-specific manner. Commensal microbiota have been shown to functionally regulate the innate and adaptive immune systems and must establish distinct niches at barrier sites throughout...
Published: 10/6/2023   |   Inventor(s): Michael Fischbach, Kazuki Nagashima, Yiyin Chen, Djenet Bousbaine
Keywords(s): Autoimmune, Bacteria, T-Cell Activation
Category(s): Technology Classifications > Biology
­BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
­BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS Researchers at Stanford have developed a new avenue for stimulating T effector and Treg immune cells in an antigen-specific manner. Commensal microbiota have been shown to functionally regulate the innate and adaptive immune systems and must establish distinct niches at barrier sites throughout...
Published: 10/6/2023   |   Inventor(s): Michael Fischbach, Kazuki Nagashima, Yiyin Chen
Keywords(s): Autoimmune, Bacteria, T-Cell Activation
Category(s): Technology Classifications > Biology
Polypeptides for Stimulation of Immune Response (Adjuvants)
Abstract: HMGN polypeptides belong to the high mobility group (HMG) family of chromosomal binding peptides. HMGN polypeptides typically function inside the cell nucleus to bind to DNA and nucleosomes and regulate the transcription of various genes. HMGN polypeptides also can be released by peripheral blood mononuclear cells. However, the extracellular...
Published: 5/22/2024   |   Inventor(s): De Yang, Joost Oppenheim, Michael Bustin
Keywords(s): Autoimmune, HMGN, immune response, immunoadjuvant, POLYPEPTIDES, Vaccine Adjuvant
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology
A Murine Model of Inflammation Based on Chronic Expression of Interferon-Gamma
Abstract: An autoimmune disease is characterized by a malfunctioning healthy immune system mistakenly attacking healthy cells, tissues, and organs. These chronic diseases likely result from interactions between genetic and environmental factors. Gender, race, and ethnicity characteristics have been linked to the development of an autoimmune disease....
Published: 4/8/2024   |   Inventor(s): Howard Young, Deborah Hodge
Keywords(s): Autoimmune, Autoinflammatory, IFNγ, immunomodulatory, immunostimulatory, Interferon gamma, Ovarian Failure Syndrome, Primary Biliary Cholangitis, Systemic lupus erythematosus, Young
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology
Fatty Acid Derivatives and Their Use for the Treatment and Prevention of Autoimmune, Inflammatory, and Pain Disorders
Abstract: The discovery and selection of suitable compounds for the treatment and prevention of autoimmune, inflammatory, and pain disorders is a significant challenge. Researchers at National Institute of Aging (NIA) mitigated this issue. They discovered and synthesized numerous novel fatty acid derivatives (novel small molecules) that may ameliorate...
Published: 4/8/2024   |   Inventor(s): Christopher Ramsden, Gregory Keyes
Keywords(s): Autoimmune, Inflammation, National Institute on Aging (NIA), Pain, Ramsden
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology
Optimized Monospecific or Bicistronic Chimeric Antigen Receptor (CAR) Constructs Targeting CD19 and CD20
Abstract: Patients with chemotherapy-refractory, diffuse large B-cell lymphoma (DLBCL) have poor prognoses. CD19 and CD20 are promising targets for the treatment of B-Cell malignancies. However, despite the initial promising results from anti-CD19 CAR therapy, only 30-35% of patients with DLBCL achieve remissions lasting longer than 2-3 years after...
Published: 8/14/2024   |   Inventor(s): James Kochenderfer, Norris Lam
Keywords(s): act, adoptive cell therapy, Autoimmune, B Cell Malignancies, BICISTRONIC, CAR, CD19, CD20, chimeric antigen receptor, Kochenderfer, Leukemia, lymphoma, Monospecific
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Oncology
Cancer Therapeutic Agents that Bind to STAT Proteins
Abstract: The National Cancer Institute, Cancer and Inflammation Program seeks parties interested in collaborative research to further co-develop inhibitors of STAT proteins for the treatment of cancer. Signal transducer and activator transcription (STAT) proteins, specifically STAT1, 2, 3, 4, 5a, 5b, and 6, are involved in the cellular and biological...
Published: 4/8/2024   |   Inventor(s): Nadya Tarasova, Olga Timofeeva, Vadim Gaponenko, Christopher Michejda, Alan Perantoni, Sergey Tarasov
Keywords(s): Autoimmune, N-terminal domain, STAT
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Application > Therapeutics
Hydrocarbon Stapled Peptides that Inhibit the Linear Ubiquitin Chain Assembly Complex (LUBAC) for the Therapy of the Activated B Cell-like (ABC) Subtype of Diffuse Large B Bell Lymphoma (A Type of Non-Hodgkin’s Lymphoma)
Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma and consists of three subtypes: activated B-cell (ABC), germinal center B-cell (GBC), and primary mediastinal B-cell (PMB). Despite advances in the front-line therapy for DLBCL, approximately one-third of patients will relapse. Substantially worse outcomes...
Published: 8/14/2024   |   Inventor(s): Louis Staudt, Yiban Yang, Federico Bernal
Keywords(s): ABC DLBCL, Activated B Cell-like, Autoimmune, Bernal, CANCER, Diffuse Large B Cell Lymphoma, INFLAMMATORY, Linear Ubiquitin-chain Assembly Complex, LUBAC, NF-κB, Non-Hodgkin’s Lymphoma, Peptide Inhibitor, Staudt, therapeutic
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, TherapeuticArea > Immunology
Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...
Published: 9/24/2024   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
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