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Search Results - small+molecule
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Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 7/15/2025
|
Inventor(s):
Huafeng Wei
Keywords(s):
Genetic Disorders
,
Inflammation
,
Neurodegenerative Diseases
,
Neurology
,
Pulmonary
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging
Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures. Problem: Tissue restoration is essential to maintain skeletal muscles after injury. Skeletal muscle regeneration is exclusively achieved by the bona fide...
Published: 6/13/2025
|
Inventor(s):
Foteini Mourkioti
,
Ji-Hyung Lee
Keywords(s):
Aging
,
Drug Target
,
Orthopedics
,
Regenerative Medicine
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Small molecule
inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057 INVENTORS Hossein Ardehali* Jason Shapiro SHORT DESCRIPTION Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects. BACKGROUND Metabolic disorders...
Published: 7/23/2025
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Inventor(s):
Keywords(s):
Cardiology and Cardiovascular disease
,
Diabetes
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
A Method for treating TNF-α-driven pathologies via Fn14 inhibition
https://wsu.technologypublisher.com/files/sites/ncs_3618.pdf
Published: 4/30/2025
|
Inventor(s):
Salah-uddin Ahmed
,
Farheen Shaikh
Keywords(s):
anti-inflammatory
,
Immunotherapy
,
small molecule
,
Therapeutics
Category(s):
Technologies > Health & Well-being > Chemistry
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 4/16/2025
|
Inventor(s):
Michael Mitchell
,
Ningqiang Gong
Keywords(s):
Bioengineering
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
,
Protein/Peptide (Non-Antibody)
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 7/9/2025
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Inventor(s):
Keywords(s):
CNS - Central Nervous System
,
Neurodegenerative disease
,
Neurology
,
PD - Parkinson's Disease
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Small Molecule
for Bladder Repair
NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A
small molecule
to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 6/10/2025
|
Inventor(s):
Keywords(s):
Drug discovery
,
Small molecule
,
Therapeutics
,
Urology
Category(s):
Life Sciences > Therapeutics
Nanotherapy to Treat Intestinal Inflammation
NU 2015-160 PRIMARY INVENTOR Arun Sharma SHORT DESCRIPTION Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function BACKGROUND Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 6/10/2025
|
Inventor(s):
Keywords(s):
Gastrointestinal and Hepatic disease
,
Inflammation
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Tumor Suppression by Retinoic Acid Pathway Inhibition
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with
small molecule
s boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024
|
Inventor(s):
Malay Haldar
,
Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Therapy for T-Cell Lymphoma
NU2022-104 INVENTORS Jaehyuk Choi* Jay Daniels Jurgen Ruland Tim Wartweig SHORT DESCRIPTION Targeting PD-1 related mechanisms for treatment of aggressive T-Cell lymphomas BACKGROUND T-cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive cancers that can be resistant to chemotherapies. The molecular pathogenesis of these cancers remains...
Published: 6/10/2025
|
Inventor(s):
Keywords(s):
Cancer/Oncology
,
Small molecule
Category(s):
Life Sciences > Therapeutics
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