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Search Results - small+molecule
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Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 4/4/2025
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Inventor(s):
Keywords(s):
Neurodegenerative disease
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Small Molecule
for Bladder Repair
NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A
small molecule
to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 4/4/2025
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Inventor(s):
Keywords(s):
Drug discovery
,
Small molecule
,
Therapeutics
,
Urology
Category(s):
Life Sciences > Therapeutics
Nanotherapy to Treat Intestinal Inflammation
NU 2015-160 PRIMARY INVENTOR Arun Sharma SHORT DESCRIPTION Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function BACKGROUND Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 4/9/2025
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Inventor(s):
Keywords(s):
Gastrointestinal and Hepatic disease
,
Inflammation
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Tumor Suppression by Retinoic Acid Pathway Inhibition
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with
small molecule
s boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024
|
Inventor(s):
Malay Haldar
,
Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Therapy for T-Cell Lymphoma
NU2022-104 INVENTORS Jaehyuk Choi* Jay Daniels Jurgen Ruland Tim Wartweig SHORT DESCRIPTION Targeting PD-1 related mechanisms for treatment of aggressive T-Cell lymphomas BACKGROUND T-cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive cancers that can be resistant to chemotherapies. The molecular pathogenesis of these cancers remains...
Published: 3/3/2025
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Inventor(s):
Keywords(s):
Cancer/Oncology
,
Small molecule
Category(s):
Life Sciences > Therapeutics
Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional
small molecule
drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 3/3/2025
|
Inventor(s):
Keywords(s):
Drug discovery
,
Proteomics
,
Small molecule
Category(s):
Life Sciences > Therapeutics
PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders
Small molecule
s that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies Problem: Imaging alpha-synuclein (αS) using noninvasive techniques such as positron emission tomography (PET) can help with the early diagnosis of synucleinopathies. Previous PET radiotracers suffer from low binding affinity...
Published: 6/6/2024
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Inventor(s):
Robert Mach
,
E. James Petersson
Keywords(s):
Imaging Agents
,
Neurodegenerative Diseases
,
Radiology
,
Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Diagnostics
,
Technology Classifications > Imaging
,
Technology Classifications > Research Tools & Reagents
Indolium 1 for Advanced Melanoma Treatment
Application A
small molecule
compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 3/28/2025
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Inventor(s):
Jack Arbiser
Keywords(s):
Oncology Treatments
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
Pyrazole Derivatives for the Treatment of Lung Cancer Tumors
A class of pyrazole derivatives that inhibit palmitoyl-transferases, resulting in increasing cancer cell responsiveness to epidermal growth factor receptor inhibitor and KRas mutant lung cancer growth inhibition as a single agent. Problem: Pancreatic and lung cancers are largely driven by either Epidermal growth factor receptor (EGFR) mutation KRAS...
Published: 5/31/2024
|
Inventor(s):
George Burslem
,
Eric Witze
Keywords(s):
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
RNA-Targeted
Small Molecule
s as Potential Antiviral Therapy (HIV, SARS etc)
Brief Description: A high error rate of HIV -I reverse transcriptase coupled with a fast replication cycle associated with HIV -1 favors rapid development and selection of drug resistant strains. Therefore, identification of
small molecule
s capable of inhibiting viral components necessary for HIV -1 proliferation continues to be of great importance....
Published: 10/28/2024
|
Inventor(s):
Benjamin Miller
,
Brian Mcnaughton
,
Peter Gareiss
,
Joseph Wedekind
Keywords(s):
AIDS
,
HIV
,
Small Molecule
,
Therapy
Category(s):
Therapeutic
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