Search Results - small+molecule

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Tumor Suppression by Retinoic Acid Pathway Inhibition
­Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024   |   Inventor(s): Malay Haldar, Ganesha Rai Bantukallu
Keywords(s): Cell Therapy, Drug Target, Immunology, Immunoncology, Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Therapy for T-Cell Lymphoma
INVENTORS Jaehyuk Choi* Jay Daniels Jurgen Ruland Tim Wartweig SHORT DESCRIPTION Targeting PD-1 related mechanisms for treatment of aggressive T-Cell lymphomas BACKGROUND T-cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive cancers that can be resistant to chemotherapies. The molecular pathogenesis of these cancers remains ill defined....
Published: 8/14/2024   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Small molecule
Category(s): Life Sciences > Therapeutics
Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders
Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies Problem: Imaging alpha-synuclein (αS) using noninvasive techniques such as positron emission tomography (PET) can help with the early diagnosis of synucleinopathies. Previous PET radiotracers suffer from low binding affinity...
Published: 6/6/2024   |   Inventor(s): Robert Mach, E. James Petersson
Keywords(s): Imaging Agents, Neurodegenerative Diseases, Radiology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents
Indolium 1 for Advanced Melanoma Treatment
Application A small molecule compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 7/30/2024   |   Inventor(s): Jack Arbiser
Keywords(s): Dermatology, Oncology, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Pyrazole Derivatives for the Treatment of Lung Cancer Tumors
A class of pyrazole derivatives that inhibit palmitoyl-transferases, resulting in increasing cancer cell responsiveness to epidermal growth factor receptor inhibitor and KRas mutant lung cancer growth inhibition as a single agent. Problem: Pancreatic and lung cancers are largely driven by either Epidermal growth factor receptor (EGFR) mutation KRAS...
Published: 5/31/2024   |   Inventor(s): George Burslem, Eric Witze
Keywords(s): Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
RNA-Targeted Small Molecules as Potential Antiviral Therapy (HIV, SARS etc)
Brief Description: A high error rate of HIV -I reverse transcriptase coupled with a fast replication cycle associated with HIV -1 favors rapid development and selection of drug resistant strains. Therefore, identification of small molecules capable of inhibiting viral components necessary for HIV -1 proliferation continues to be of great importance....
Published: 5/7/2024   |   Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Joseph Wedekind
Keywords(s): AIDS, HIV, Small Molecule, Therapy
Category(s): Therapeutic
Small Molecule Activators of Valosin-Containing Protein (VCP) as Therapeutics for Neurodegenerative Diseases with Ubiquitinated Protein Aggregates
Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases. Problem: Dementia, characterized by the impairment of at least two brain functions, such as memory loss and judgment, currently has no cure. Two common neurodegenerative diseases that cause dementia are Frontotemporal Dementia (FTD) and...
Published: 2/9/2024   |   Inventor(s): Edward Lee, Benjamin Creekmore, Jessica Phan
Keywords(s): Aging, Genetic Disorders, Neurodegenerative Diseases, Neurology, Orphan Disease, Small Molecule
Category(s): Technology Classifications > Therapeutics
Cancer Therapeutic Based on Hypoxia Inducible Factor 1 (HIF-1) Inhibitors
Abstract: Hypoxia is a characteristic of many solid tumors resulting from accelerated cellular proliferation and inadequate vascularization. HIF-1 is a transcription factor critical for maintaining cellular homeostasis in, and adaptively responding to, low oxygen environments. HIF-1 becomes activated through binding to the transcriptional co-activator...
Published: 4/8/2024   |   Inventor(s): Kirk Gustafson, Martin Schnermann, Susanna Chan, Paresma Patel, William Figg, James McMahon
Keywords(s): CANCER, Hypoxia Inhibitor, Malaria, small molecule
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Peptide Hydrogels for Rate-Controlled Delivery of Therapeutics
Abstract: Hydrogels represent an attractive controlled drug-delivery system that have been used in various clinical applications, such as: tissue engineering for wound healing, surgical procedures, pain management, cardiology, and oncology. High-water content of hydrogels confers tissue-like physical properties and the crosslinked fibrillar network...
Published: 4/8/2024   |   Inventor(s): Joel Schneider, Stephen Miller, Yuji Yamada, Steven Tau, Julie Hixon, Wenqing Li, Caroline Andrews, Scott Walsh
Keywords(s): DEVICE, IL-7, Nanoparticle, Peptide, Peptide-based Hydrogel, Protein, Schneider, small molecule, T Cell Enhancer, Whole Cell Delivery System
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Immunology
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