Search Results - small+molecule

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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU 2025-212 IP STATUS US...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Selective PAD2 Inhibitors for Neuroprotection in Traumatic Brain Injury
SHORT DESCRIPTION Novel PAD2-selective inhibitor platform targeting neuroinflammation to support both acute neuroprotection and long-term functional recovery as a first-in-class treatment of traumatic brain injury. INVENTORS Hasan Alam* Northwestern University Feinberg School of Medicine, Department of Surgery (Trauma...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, CVA - Cerebrovascular Accident, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
Methods to Treat Neurodegenerative Disorders by Reducing Nuclear Aggregates and Modulating Adenosine‑to‑Inosine RNA Editing
SHORT DESCRIPTION Novel disease‑modifying approach that dissolves toxic nuclear RNA–protein aggregates and restores synaptic function in neurodegenerative diseases by inhibiting adenosine‑to‑inosine (A‑to‑I) RNA editing and modulating ADAR enzymes. INVENTORS Joseph Mazzulli* Northwestern University Feinberg School...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): Lewy bodies, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, RNA - Ribonucleic Acid, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
PROPOSED TITLE (cut & paste into Alternate Title): Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention NU 2023-007 SHORT DESCRIPTION A small molecule based approach that mitigates Alzheimer's neurodegeneration by inhibiting neuronal nitric oxide synthase to prevent tau phosphorylation and reduce Aβ oligomer formation. INVENTORS Richard...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Covalent inhibitor, Kinase Inhibitor, Neurodegenerative disease, Neurology, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
N-desmethyl Tamoxifen and Derivatives for Effective Pain Relief
SHORT DESCRIPTION A novel state-dependent tamoxifen‑derived small molecule anti-pain medication that selectively blocks peripheral voltage‑gated sodium channels to deliver potent, non‑opioid analgesia in chronic and inflammatory pain. INVENTORS Paul DeCaen* Northwestern University Feinberg School of Medicine, Department...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): Chronic pain, Neurology, Non-opioid, Pain management, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Small Molecule Inhibitors of Pleckstrin-2 for Treating Myeloproliferative Neoplasms
SHORT DESCRIPTION Small molecule inhibitors of Pleckstrin-2 (Plek2) for treating cell proliferative diseases and disorders, particularly myeloproliferative neoplasms (MPNs). NU Tech IDs: NU 2018-169, NU 2021-005 PRINCIPAL INVESTIGATOR Peng Ji Northwestern University Feinberg School of Medicine, Department of Pathology IP...
Published: 4/16/2026   |   Updated: 4/16/2026   |   Inventor(s):  
Keywords(s): Breast cancer, Cancer/Oncology, Colon cancer, Leukemia, Lung cancer, Pancreatic cancer, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Benzofuranoindoline-Containing Fungal RiPP-Derived Anticancer Compounds
Benzofuranoindoline-containing fungal RiPP-derived compounds and analogs, plus pharmaceutical compositions, and administration methods for treating cancers, including leukemia. Problem: The disclosure targets diseases and disorders where new therapeutic compounds are needed, including cancers such as leukemia. Fungal ribosomally synthesized and post-translationally...
Published: 4/16/2026   |   Updated: 4/16/2026   |   Inventor(s): Xue Sherry Gao, Hans Renata, Qiuyue Nie
Keywords(s): Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture
Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss. Problem: Millions of people worldwide suffer from disrupted sleep, whether due...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s): Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s): Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s): Technology Classifications > Therapeutics
JNK Inhibitors Targeting Bergmann Glia Inflammation to Mitigate Spinocerebellar Ataxia and Other Neurodegenerative Disorders
SHORT DESCRIPTION Novel therapeutic strategy targeting Bergmann glia inflammation using JNK inhibition for treatment of spinocerebellar ataxia type 1 (SCA1) and other neurodegenerative disorders. INVENTORS Puneet Opal* Northwestern University Feinberg School of Medicine, Professor of Neurology Chandrakanth...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Bergmann glia inflammation, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Rare diseases, SCA - Spinocerebellar ataxia, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Selective Receptor Modulators for Skin Depigmentation
Small-molecule compositions modulate non-canonical sex steroid receptors to decrease, prevent, or reverse skin pigmentation gain in mammalian subjects. Problem: Skin hyperpigmentation can arise from pregnancy, hormones, inflammatory conditions, or skin injury. Existing approaches may not address receptor pathways that regulate melanocyte pigmentation....
Published: 4/6/2026   |   Updated: 4/6/2026   |   Inventor(s): Todd Ridky, Christopher Natale
Keywords(s): Dermatology, Small Molecule
Category(s): Technology Classifications > Therapeutics
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