Search Results - small+molecule

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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098 Inventors Leonidas C. Platanias* Gary E. Schiltz Rama K. Mishra Short Description A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway. Background Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 3/5/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy. INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* Jindan...
Published: 3/5/2026   |   Inventor(s):  
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
c‑Abl Modulators for Neurodegenerative Disease Treatment
Application Small‑molecule c‑Abl inhibitors designed to treat neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Key Benefits Targets c‑Abl, a key regulator linked to neurodegeneration, oxidative stress, and loss of dopaminergic neurons. Provides new small‑molecule scaffolds with potential for improved safety profiles...
Published: 3/2/2026   |   Inventor(s): Thomas Kaiser, Zackery Dentmon, Christopher Dalloul, Dennis Liotta
Keywords(s): Drug Target Identification, Neurology and Pain Treatments, Rare and Orphan Disease Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
Methods of Using Modified Cytotoxins to Treat Cancer
NU 2019-135 INVENTORS Nathan Gianneschi* SHORT DESCRIPTION Methods for treating cancers that overexpress fatty acid uptake proteins using small-molecule cytotoxic drugs conjugated to long-chain fatty acid moieties. See also NU2022-111 and NU2022-109. BACKGROUND While prior work (under NU2022-111) demonstrated that lipid-mimicking cytotoxin...
Published: 2/26/2026   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Novel Serotonin Receptor Agonist to Treat Neurological Disease
NU 2018-135 INVENTORS Karl Scheidt* Adam Csakai Herbert Meltzer SHORT DESCRIPTION A novel small molecule that selectively targets serotonin 5-HT2c receptors for the treatment of psychiatric, mental, and/or neurological diseases. BACKGROUND Serotonin is a neurotransmitter known to regulate a variety of neurological functions, and alterations in...
Published: 2/24/2026   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2018-176, NU 2024-250, NU 2025-038) INVENTORS Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry) SHORT DESCRIPTION Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer)...
Published: 3/4/2026   |   Inventor(s):  
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Immunotherapy, Melanoma, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081 INVENTORS Sarki Abdulkadir (PI)* Gary Schiltz (PI)* SHORT DESCRIPTION A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer. BACKGROUND Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...
Published: 2/6/2026   |   Inventor(s):  
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases. BACKGROUND Neurodegenerative disorders such as...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 1/20/2026   |   Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee
Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
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