Search Results - small+molecule

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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases. BACKGROUND Neurodegenerative disorders such as...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 12/9/2025   |   Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee
Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
A Potent HIV Treatment with Low Toxicity
A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells. Problem: 37 million people worldwide currently live with HIV and an estimated 2-3 million new infections occur annually. While antiretroviral therapies do exist for those with the disease, therapy interruption leads to the re-emergence of...
Published: 11/11/2025   |   Inventor(s): Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert
Keywords(s): Drug Target, HIV/AIDS, Small Molecule, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Novel AKR1C3 Inhibitors in Cancer
Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Value Proposition: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward side...
Published: 10/30/2025   |   Inventor(s): Trevor Penning, Adegoke Adeniji, Michael Byrns, Jeffrey Winkler, Barry Twenter, Lawrence Marnett, Andy Liedtke
Keywords(s): Men's Health, Oncology, Small Molecule, Women's Health
Category(s): Technology Classifications > Therapeutics
Molecules Targeting Inflammatory Signaling
Application A group of small molecules for treating central and peripheral diseases associated with inflammation. Key Benefits Applicable to a wide variety of central nervous system and peripheral diseases. Can bypass side effects of existing therapeutics targeting similar inflammatory pathways. High target selectivity and aqueous solubility. Capability...
Published: 12/5/2025   |   Inventor(s): Raymond (Ray) Dingledine, Radhika Amaradhi, Shabber Mohammed, Thota Ganesh
Keywords(s): Immunology and Inflammation Treatments, Neurology and Pain Treatments, Oncology Treatments, Small Molecule, Women's Health
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 9/30/2025   |   Inventor(s): Huafeng Wei
Keywords(s): Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule
Category(s): Technology Classifications > Therapeutics
DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging
Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures. Problem: Tissue restoration is essential to maintain skeletal muscles after injury. Skeletal muscle regeneration is exclusively achieved by the bona fide...
Published: 8/5/2025   |   Inventor(s): Foteini Mourkioti, Ji-Hyung Lee
Keywords(s): Aging, Drug Target, Orthopedics, Regenerative Medicine, Small Molecule
Category(s): Technology Classifications > Therapeutics
Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057 INVENTORS Hossein Ardehali* Jason Shapiro SHORT DESCRIPTION Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects. BACKGROUND Metabolic disorders...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 12/8/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics
Small Molecule for Bladder Repair
NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
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