Search Results - obesity

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Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)
UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...
Published: 9/24/2024   |   Inventor(s): Zhen Gu
Keywords(s): glucose intolerance, liver fibrosis, Nanoparticles, Notch signaling pathway, obesity
Category(s): Therapeutics > Metabolism And Endocrinology
Development and Characterization of the SLC46A3 Knockout Mouse Line
Abstract: Nonalcoholic fatty liver disease is caused by several factors including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. TCDD causes lipid accumulation in humans by inducing the Solute Carrier Family 46 Member 3 (SLC46A3) gene expression. To effectively study TCDD-mediated lipid accumulation, research tools such as...
Published: 4/8/2024   |   Inventor(s): Frank Gonzalez, Sun Hee Yim, Jung-Hwan Kim
Keywords(s): 2, 3, 7, 8-tetracholodibenzo-p-dioxin, Gonzalez, hepatocellular carcinoma, Knockout Mouse, Liver cancer, Major Facilitator Superfamily, MFS, Nonalcoholic fatty liver disease, OBESITY, SLC46A3, Solute Carrier Family, TCDD
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Endocrinology
Substituted Quinoline Analogs as Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors
Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Unbalanced biological activity of ALDHs has been associated with a variety of disease states such as alcoholic liver disease, Parkinson’s disease, obesity, and Cancer. Increased expression of ALDH1A1...
Published: 7/25/2024   |   Inventor(s): Anton Simeonov, David Maloney, Natalia Martinez, Adam Yasgar, Shyh-Ming Yang
Keywords(s): 1A1, 3D spheroid, ALDEFLUOR assay, Aldehyde, ALDH, ALDH1A1, cancer stem cells, combined treatment, DEHYDROGENASE, high-content imaging, high-throughput screening, Inhibitors, liver, METABOLIC, MOLECULE, OBESITY, OV-90, Parkinson, RESISTANT, SKOV-3, Small
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and Aging
The catalytic subunit of the DNA-dependent protein kinase complex (DNA-PKcs) has been shown to be important in DNA repair and VDJ recombination in lymphocytes. The inventors have discovered that DNA-PKcs also plays novel, important roles in energy regulation and neurological function. The inventors observed that mature DNA-PKcs-deficient mice (also...
Published: 7/25/2024   |   Inventor(s): Jay Chung
Keywords(s): Aging, ANXIETY, Cardiovascular, depression, DIABETES, DNA-Dependent, DNA-PKcs, Endurance, Energy, HEART, IB1XXX, IB3XXX, IB6XXX, IBXXXX, Inflammation, insulin, INSULIN-DEPENDENT, IXXXXX, LEARNING, MEMORY, METABOLIC, Metabolism, Mitochondria, Neurological, OBESITY, REGULATION, TYPE-2, Weight
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology
2022-088 Neural Networks for Adipose Tissue Segmentation on Magnetic Resonance Images
Summary: UCLA researchers in the Department of Radiological Sciences have developed a novel neural network that can segment and quantify visceral and subcutaneous adipose tissues on magnetic resonance images automatically, accurately, and rapidly, to enhance clinical methods for characterizing and monitoring risk for cardiometabolic diseases in patients...
Published: 7/31/2024   |   Inventor(s): Holden Wu, Sevgi Gokce Kafali-Tekat
Keywords(s): Advanced Computing / AI, Artificial Neural Network, Artificial Neural Network Artificial Neuron, cardiometabolic disease, Hypertension, Imaging, Machine Learning, Magnetic Resonance Imaging, Magnetic Resonance Imaging Pathology, Medical Imaging, MRI, multi-contrast imaging, obesity, Tissue (Biology), tissue annotation, tissue detection, tissue ribbons alignment, tissue segmentation
Category(s): Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > MRI, Therapeutics > Metabolism And Endocrinology
The HAPPY (Having a Positive Perception of You) App
­The US is experiencing an epidemic of diabetes, heart disease and mental health problems associated with overweight, especially among children and adolescents. Body Mass Index (BMI) is a widely used tool to assess for risk of overweight or obesity and to serve as a basis for referral and treatment. However, BMI cannot distinguish muscle from fat,...
Published: 2/23/2023   |   Inventor(s): Annmarie Lyles, Ashish Amresh
Keywords(s): Device, Health Monitoring, Obesity, Web and Database Applications
Category(s): Educational, Life Science (All LS Techs), Computing & Information Technology
Treatment for Metabolic Syndrome and Obesity Related Diseases
Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...
Published: 8/4/2022   |   Inventor(s): Jan Frederik Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio
Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes
Category(s): Therapeutics
Immune CB1 Activation for Obesity Therapy
Reference #: 01478 The University of South Carolina is offering licensing opportunities for Immune CB1 activation for obesity therapy Background: The endocannabinoid system regulates various physiological processes such as inflammation and metabolism, and is comprised of cannabinoid receptors, CB1 and CB2, as well as their ligands called endocannabinoids....
Published: 5/22/2024   |   Inventor(s): Prakash Nagarkatti, Mitzi Nagarkatti, Kathryn Miranda
Keywords(s): anti-inflammatory pharma, cannabinoids, CB1, inflammation, metabolic syndrome, Obesity, weight loss
Category(s): Health Sciences, Biomedical and Life Sciences
Platelet Factor 4 as a Biomarker of Defective Lymphatics
NU 2020-158 INVENTORS Guillermo Oliver* Stanley Rockson SHORT DESCRIPTION A new biomarker for identifying lymphatic vasculature diseases BACKGROUND Lymphatic vasculature defects often result in disfiguring, disabling, and, occasionally, life-threatening outcomes. Diagnostic tools for all of the lymphatic disorders are relatively limited, relying...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Assay, Biomarker, Diagnostics, Obesity, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Compositions and Methods to Treat Inflammatory Joint Disease
TechnologyInflammatory joint disease is an autoimmune condition that afflicts more than 54 million adults in the United States. It’s commonly characterized by joints that exhibit pain, stiffness, and redness that ultimately leads to severe disability and premature death. Incidence of the disease is rapidly growing due to rising obesity rates,...
Published: 3/6/2024   |   Inventor(s): Paula Carpintero Fernandez, Maria Mayan Santos, Francisco Blanco Garcia, Gary Goldberg
Keywords(s): Autoimmune/Immunology, Disease, Inflammatory, Joint, Obesity, Protein
Category(s): Human Health Care > Therapeutics, Human Health Care > Biomarkers, Diagnosis and Detection
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