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Search Results - biologic
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Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Inventor(s):
Keywords(s):
Biologic
,
Biomarker
,
Biomedical
,
Cancer/Oncology
,
Chemicals
,
Diagnostics
,
Drug delivery
,
Nanoparticle
,
Nanotechnology
,
Personalized medicine
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
,
Life Sciences > Healthcare Devices, Tools & IT
,
Life Sciences > Biomarkers & Biomedical Research Tools
A CSF-derived therapy for psychiatric disorders
NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Biologic
,
Psychiatric disease
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Fully-human Heavy-chain-only Anti-B-cell Maturation Antigen (BCMA) Chimeric Antigen Receptors (CARs)
Abstract: Immortalization of plasma cells leads to plasma cell malignancy diseases such as multiple myeloma (MM). B-cell maturation antigen (BCMA) is a protein that is preferentially expressed by malignant and normal B cells and plasma cells, butnot on other cells in the body. This limited expression profile suggests that BCMA is a promising target...
Published: 5/14/2025
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Inventor(s):
James Kochenderfer
,
Norris Lam
,
Benjamin Buelow
Keywords(s):
act
,
adoptive cell therapy
,
B-cell Malignancies
,
B-cell Maturation Antigen
,
BCMA
,
BIOLOGIC
,
CANCER
,
CAR
,
chimeric antigen receptor
,
Hodgkin Lymphoma
,
Hodgkin’s Lymphoma
,
Kochenderfer
,
Mm
,
MULTIPLE MYELOMA
,
Non-Hodgkin Lymphoma
,
Non-Hodgkin’s Lymphoma
,
Plasma Cell Malignancies
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Biologic
,
Gene therapy
,
Infectious disease
,
Research tool
,
RNA - Ribonucleic Acid
,
Therapeutics
,
Vector/Plasmid
Category(s):
Life Sciences > Therapeutics
Frog Skin Peptides for Treatment of Human Influenza Viruses
Application A therapeutic peptide that treats Influenza A virus Key Benefits New method of action compared to antiviral drugs currently in use. Therapeutic peptide is virucidal against drug resistant strains. Market Summary Worldwide seasonal influenza epidemics can impact 5 – 15% of the population. The occurrence of vaccine mismatch...
Published: 7/30/2024
|
Inventor(s):
Joshy Jacob
,
David Holthausen
,
Song Lee
,
Sanil George
Keywords(s):
Biologic
,
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Therapeutics
Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159 INVENTORS Guillermo Oliver* Xialoei Liu SHORT DESCRIPTION A novel approach to treating cardiovasculature disease BACKGROUND Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 12/11/2025
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Inventor(s):
Keywords(s):
Biologic
,
Cardiology and Cardiovascular disease
,
Regenerative medicine
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
HPS1 and HPS4 Function as RNAi Inhibitors: A Means to Boost RNAi for Experimental, Therapeutic & Commercial Purposes
NU 2005-063BInventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well as for controlling viral infections....
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Assay
,
Biologic
,
Gene therapy
,
Therapeutics
,
Vector/Plasmid
Category(s):
Life Sciences > Therapeutics
A Novel RNA Therapeutic Candidate for Fibrotic Diseases
LU 2015-101 InventorsAnn Harris*Lindsay Stolzenburg Short DescriptionA microRNA drug candidate that treats fibrotic diseases through the repression of TGF-β receptor expression. AbstractNorthwestern researchers have identified an innovative therapeutic strategy to treat acute and chronic fibrotic diseases. Progression of fibrosis involves repeated...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Biologic
,
Inflammation
,
RNA - Ribonucleic Acid
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Magnetically-triggered Drug Delivery System for Growth Factors and Biomacromolecules
Allows Externally-Controlled Delivery of Large Macromolecules for Dynamic, Spatial and Temporal Release Of
Biologic
sThis drug delivery system addresses the previously unmet need of a controlled drug-release platform for large biomolecules, such as growth factors and proteins. Controlled drug-release technology is one of the most rapidly growing technologies...
Published: 6/27/2021
|
Inventor(s):
Jon Dobson
,
Peter McFetridge
,
Olivia Lanier
Keywords(s):
biologic
,
Growth factor
,
Microparticle
Category(s):
Technology Classifications > Human Health Care > Drug Delivery
Development of Neuroprotective Therapeutics Based on Stroke-Induced Secretory Proteins
NU 2010-125InventorShu Q. LiuShort Description A
biologic
for neuroprotection during the acute phase of a strokeBackgroundStroke is the leading cause of serious, long-term disability in the United States. As adult neurons possess a limited capacity for protection and regeneration, infarcted brain tissue is often replaced with fibrotic tissues, resulting...
Published: 11/6/2025
|
Inventor(s):
Keywords(s):
Biologic
,
CVA - Cerebrovascular Accident
,
Neurologic disease
,
Neurology
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
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