Search Results - biologic

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A CSF-derived therapy for psychiatric disorders
NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s): Biologic, Psychiatric disease, Therapeutics
Category(s): Life Sciences > Therapeutics
MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 10/28/2024   |   Inventor(s): Rama Rao Amara, Sailaja Gangadhara
Keywords(s): Biologic, COVID19, Immunology/Inflammation, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines
Vaccines and Antibody Therapeutics for HPV-related Cancers
Application Treatment and prevention of HPV-induced malignancies. Key Benefits Identification of a protein expressed in a large number of HPV-induced cancers. Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells. The antibodies can be used to develop new treatments and vaccines...
Published: 11/20/2024   |   Inventor(s): Rafi Ahmed, Andreas Wieland
Keywords(s): Biologic, Microbiology/Infectious Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Fully-human Heavy-chain-only Anti-B-cell Maturation Antigen (BCMA) Chimeric Antigen Receptors (CARs)
Abstract: Immortalization of plasma cells leads to plasma cell malignancy diseases such as multiple myeloma (MM). B-cell maturation antigen (BCMA) is a protein that is preferentially expressed by malignant and normal B cells and plasma cells, butnot on other cells in the body. This limited expression profile suggests that BCMA is a promising target...
Published: 8/14/2024   |   Inventor(s): James Kochenderfer, Norris Lam, Benjamin Buelow
Keywords(s): act, adoptive cell therapy, B-cell Malignancies, B-cell Maturation Antigen, BCMA, BIOLOGIC, CANCER, CAR, chimeric antigen receptor, Hodgkin Lymphoma, Hodgkin’s Lymphoma, Kochenderfer, Mm, MULTIPLE MYELOMA, Non-Hodgkin Lymphoma, Non-Hodgkin’s Lymphoma, Plasma Cell Malignancies
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 9/12/2024   |   Inventor(s):  
Keywords(s): Biologic, Gene therapy, Infectious disease, Research tool, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 7/30/2024   |   Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Keywords(s): Biologic, Biomarker, Oncology, Repurposed Drug, Target
Category(s): TechPub Algolia > Diagnostics
Frog Skin Peptides for Treatment of Human Influenza Viruses
Application A therapeutic peptide that treats Influenza A virus Key Benefits New method of action compared to antiviral drugs currently in use. Therapeutic peptide is virucidal against drug resistant strains. Market Summary Worldwide seasonal influenza epidemics can impact 5 – 15% of the population. The occurrence of vaccine mismatch...
Published: 7/30/2024   |   Inventor(s): Joshy Jacob, David Holthausen, Song Lee, Sanil George
Keywords(s): Biologic, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Therapeutics
Frog Skin Peptides for Treatment of Zika Viruses
Application A therapeutic peptide that treats Zika Virus. Key Benefits Potential therapeutic to fight against the growing threat of the Zika virus. Peptide is fast acting and destroys Zika virions within 5 minutes of exposure. Market Summary Zika is an infectious disease spread primarily by Aedes mosquitoes and results in symptoms similar to...
Published: 11/20/2024   |   Inventor(s): Joshy Jacob, Song Lee, David Holthausen, Sanil George
Keywords(s): Biologic, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Therapeutics
Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159 INVENTORS Guillermo Oliver* Xialoei Liu SHORT DESCRIPTION A novel approach to treating cardiovasculature disease BACKGROUND Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biologic, Cardiology and Cardiovascular disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 11/20/2024   |   Inventor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
Keywords(s): Biologic, Enzyme/Protein, Immunology/Inflammation, Oncology
Category(s): TechPub Algolia > Therapeutics
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