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Search Results - biologic
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets. INVENTORS Shana Kelley* Weinberg College of Arts & Sciences, Department of Chemistry Yi Li * Principal Investigator NU 2025-050 IP STATUS PCT...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s):
AD - Alzheimer’s Disease
,
Biologic
,
Biomolecular condensates
,
Cancer/Oncology
,
Drug delivery
,
Nanoparticle
,
Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
PD - Parkinson's Disease
,
Platform technology
,
Targeted protein degradation
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
,
Life Sciences > Biomarkers & Biomedical Research Tools
Anti-TYRP1 Bi-specific T cell Engager for Treatment of TYRP1-expressing melanoma
NU 2022-123 INVENTORS Irina Balyasnikova (Feinberg School of Medicine, Department of Neurological Surgery)* Isabelle Le Poole (Feinberg School of Medicine, Department of Dermatology)* SHORT DESCRIPTION A bispecific T cell engager that targets CD3+ T cells and TYRP1-expressing melanoma cells. BACKGROUND Melanoma is the deadliest form of skin...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s):
Biologic
,
Cancer/Oncology
,
Immunotherapy
,
Melanoma
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
NU 2024-047 SHORT DESCRIPTION An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares. INVENTORS Arthur Prindle* McCormick School of Engineering, Department of Chemical and
Biologic
al Engineering Jonathan...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s):
Autoimmune disease
,
Biologic
,
Cell therapy
,
Diagnostics
,
Gastrointestinal and Hepatic disease
,
IBD - Inflammatory bowel disease
,
Immunology
,
Immunotherapy
,
Inflammation
,
Synthetic biology
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Recombinant Annexin Therapy for Muscle, Cardiac, and Neuronal Cell Membrane Repair
NU 2022-008 SHORT DESCRIPTION An annexin-based
biologic
al therapeutic that enhances the body's natural cell membrane repair process to reduce skeletal muscle, cardiac, and neuronal cell death and preserve tissue function. INVENTORS INVENTORS Elizabeth McNally* Feinberg School of Medicine, Department of Medicine (Cardiology...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s):
Biologic
,
Cardiomyopathy
,
DMD - Duchenne muscular dystrophy
,
Inflammation
,
Membrane injury and repair
,
Neurodegenerative disease
,
Rare diseases
,
SCI - Spinal cord injury
,
TBI - Traumatic brain injury
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Antibodies for treatment of coronavirus disease
NU 2023-247 INVENTORS Huiping Liu* Deyu Fang* Hannah Mubarak Andrew Hoffmann Nurmaa Dashzeveg Lamiaa El-Shennawy Juncheng Wei Wuwei Tan Yang Shen SHORT DESCRIPTION Computationally redesigned antibodies targeting SARS-CoV-2 for treating COVID-19. BACKGROUND The continuous evolution of SARS-CoV-2 has allowed the virus to escape most therapeutic...
Published: 2/26/2026
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Updated: 2/26/2026
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Inventor(s):
Keywords(s):
Antibody
,
Artificial Intelligence & Machine Learning
,
Biologic
,
Infectious disease
,
Research tool
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146 INVENTORS Jennifer Wu* SHORT DESCRIPTION A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer. BACKGROUND Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 4/9/2026
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Updated: 12/3/2025
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Inventor(s):
Keywords(s):
Antibody
,
Biologic
,
Cancer/Oncology
,
Immunotherapy
,
Infectious disease
,
Research tool
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025
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Updated: 10/30/2025
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Inventor(s):
Keywords(s):
Biologic
,
Biomarker
,
Biomedical
,
Cancer/Oncology
,
Chemicals
,
Diagnostics
,
Drug delivery
,
Nanoparticle
,
Nanotechnology
,
Personalized medicine
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
,
Life Sciences > Healthcare Devices, Tools & IT
,
Life Sciences > Biomarkers & Biomedical Research Tools
Anti-PODXL Antibody for Inhibiting Metastasis in Breast Cancer
NU 2023-110 INVENTORS Huiping Liu* Nurmaa Dashzeveg SHORT DESCRIPTION This technology introduces methods of use for an anti-PODXL antibody that effectively prevents and treats metastasis in breast cancer by inhibiting circulating tumor cell (CTC) cluster formation. BACKGROUND Cancer metastasis is mediated by circulating tumor cells (CTC) and...
Published: 4/13/2026
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Updated: 1/28/2025
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Inventor(s):
Keywords(s):
Adjunct therapy
,
Antibody
,
Biologic
,
Breast cancer
,
Cancer/Oncology
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
A CSF-derived therapy for psychiatric disorders
NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 4/14/2026
|
Updated: 10/17/2024
|
Inventor(s):
Keywords(s):
ASD - Autism Spectrum Disorder
,
Biologic
,
Neurologic disease
,
Neurology
,
PSD - Psychotic spectrum disorder
,
Psychiatric disease
,
Schizophrenia
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Fully-human Heavy-chain-only Anti-B-cell Maturation Antigen (BCMA) Chimeric Antigen Receptors (CARs)
Abstract: Immortalization of plasma cells leads to plasma cell malignancy diseases such as multiple myeloma (MM). B-cell maturation antigen (BCMA) is a protein that is preferentially expressed by malignant and normal B cells and plasma cells, butnot on other cells in the body. This limited expression profile suggests that BCMA is a promising target...
Published: 5/14/2025
|
Updated: 8/2/2023
|
Inventor(s):
James Kochenderfer
,
Norris Lam
,
Benjamin Buelow
Keywords(s):
act
,
adoptive cell therapy
,
B-cell Malignancies
,
B-cell Maturation Antigen
,
BCMA
,
BIOLOGIC
,
CANCER
,
CAR
,
chimeric antigen receptor
,
Hodgkin Lymphoma
,
Hodgkin’s Lymphoma
,
Kochenderfer
,
Mm
,
MULTIPLE MYELOMA
,
Non-Hodgkin Lymphoma
,
Non-Hodgkin’s Lymphoma
,
Plasma Cell Malignancies
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
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