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Search Results - biologic
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A CSF-derived therapy for psychiatric disorders
NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 10/17/2024
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Inventor(s):
Keywords(s):
Biologic
,
Psychiatric disease
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Fully-human Heavy-chain-only Anti-B-cell Maturation Antigen (BCMA) Chimeric Antigen Receptors (CARs)
Abstract: Immortalization of plasma cells leads to plasma cell malignancy diseases such as multiple myeloma (MM). B-cell maturation antigen (BCMA) is a protein that is preferentially expressed by malignant and normal B cells and plasma cells, butnot on other cells in the body. This limited expression profile suggests that BCMA is a promising target...
Published: 8/14/2024
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Inventor(s):
James Kochenderfer
,
Norris Lam
,
Benjamin Buelow
Keywords(s):
act
,
adoptive cell therapy
,
B-cell Malignancies
,
B-cell Maturation Antigen
,
BCMA
,
BIOLOGIC
,
CANCER
,
CAR
,
chimeric antigen receptor
,
Hodgkin Lymphoma
,
Hodgkin’s Lymphoma
,
Kochenderfer
,
Mm
,
MULTIPLE MYELOMA
,
Non-Hodgkin Lymphoma
,
Non-Hodgkin’s Lymphoma
,
Plasma Cell Malignancies
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 9/12/2024
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Inventor(s):
Keywords(s):
Biologic
,
Gene therapy
,
Infectious disease
,
Research tool
,
Therapeutics
,
Vector/Plasmid
Category(s):
Life Sciences > Therapeutics
Frog Skin Peptides for Treatment of Human Influenza Viruses
Application A therapeutic peptide that treats Influenza A virus Key Benefits New method of action compared to antiviral drugs currently in use. Therapeutic peptide is virucidal against drug resistant strains. Market Summary Worldwide seasonal influenza epidemics can impact 5 – 15% of the population. The occurrence of vaccine mismatch...
Published: 7/30/2024
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Inventor(s):
Joshy Jacob
,
David Holthausen
,
Song Lee
,
Sanil George
Keywords(s):
Biologic
,
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Therapeutics
Frog Skin Peptides for Treatment of Zika Viruses
Application A therapeutic peptide that treats Zika Virus. Key Benefits Potential therapeutic to fight against the growing threat of the Zika virus. Peptide is fast acting and destroys Zika virions within 5 minutes of exposure. Market Summary Zika is an infectious disease spread primarily by Aedes mosquitoes and results in symptoms similar to...
Published: 11/20/2024
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Inventor(s):
Joshy Jacob
,
Song Lee
,
David Holthausen
,
Sanil George
Keywords(s):
Biologic
,
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Therapeutics
Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159 INVENTORS Guillermo Oliver* Xialoei Liu SHORT DESCRIPTION A novel approach to treating cardiovasculature disease BACKGROUND Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 4/4/2025
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Inventor(s):
Keywords(s):
Biologic
,
Cardiology and Cardiovascular disease
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
HPS1 and HPS4 Function as RNAi Inhibitors: A Means to Boost RNAi for Experimental, Therapeutic & Commercial Purposes
NU 2005-063BInventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well as for controlling viral infections....
Published: 7/3/2024
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Inventor(s):
Keywords(s):
Assay
,
Biologic
,
Gene therapy
,
Therapeutics
,
Vector/Plasmid
Category(s):
Life Sciences > Therapeutics
A Novel RNA Therapeutic Candidate for Fibrotic Diseases
LU 2015-101 InventorsAnn Harris*Lindsay Stolzenburg Short DescriptionA microRNA drug candidate that treats fibrotic diseases through the repression of TGF-β receptor expression. AbstractNorthwestern researchers have identified an innovative therapeutic strategy to treat acute and chronic fibrotic diseases. Progression of fibrosis involves repeated...
Published: 7/3/2024
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Inventor(s):
Keywords(s):
Biologic
,
Inflammation
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Magnetically-triggered Drug Delivery System for Growth Factors and Biomacromolecules
Allows Externally-Controlled Delivery of Large Macromolecules for Dynamic, Spatial and Temporal Release Of
Biologic
sThis drug delivery system addresses the previously unmet need of a controlled drug-release platform for large biomolecules, such as growth factors and proteins. Controlled drug-release technology is one of the most rapidly growing technologies...
Published: 6/27/2021
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Inventor(s):
Jon Dobson
,
Peter McFetridge
,
Olivia Lanier
Keywords(s):
biologic
,
Growth factor
,
Microparticle
Category(s):
Technology Classifications > Human Health Care > Drug Delivery
Development of Neuroprotective Therapeutics Based on Stroke-Induced Secretory Proteins
NU 2010-125InventorShu Q. LiuShort Description A
biologic
for neuroprotection during the acute phase of a strokeBackgroundStroke is the leading cause of serious, long-term disability in the United States. As adult neurons possess a limited capacity for protection and regeneration, infarcted brain tissue is often replaced with fibrotic tissues, resulting...
Published: 7/3/2024
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Inventor(s):
Keywords(s):
Biologic
,
Neurologic disease
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
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