Search Results - changying+shi

13 Results Sort By:
Prodrug Nanoformulations of Amphotericin B conjugated Phenylboronic acid containing Telodendrimer Nanocarriers in Systemic Fungal Infections Treatment
This technology uses telodendrimer prodrugs combined with boronate chemistry to improve drug delivery and effectiveness. Background: The field of drug delivery has seen significant advancements over the past few decades, particularly in the development of targeted therapies that can improve the efficacy and safety profiles of pharmaceutical agents....
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): Technologies
Category(s): Technology Classifications > Drug Delivery, Campus > Upstate Medical University
Bioactive Telodendrimer Nanocarrier for Antibiotics Delivery and Immune Modulation
Novel telodendrimer nanoparticles have been developed to enhance the delivery and safety profile of the antibiotic Polymyxin B by improving its stability and reducing toxicity during treatment. Background: Polymyxin B (PMB) is a powerful antibiotic used to treat infections caused by Gram-negative bacteria, but its clinical application is limited...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Juntao Luo, Dandan Guo, Md Shanewaz Hossan, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
A Method to Accelerate Federated Learning via Client Hopping
THE CHALLENGE Organizations across healthcare, finance, manufacturing, and edge computing increasingly look to federated learning to extract value from sensitive, distributed data while maintaining privacy and regulatory compliance. Yet scaling this technology into a reliable commercial solution remains challenging, as current architectures struggle...
Published: 5/5/2026   |   Updated: 3/24/2026   |   Inventor(s): Fangtong Zhou, Yi Shi, Yiwei Thomas Hou
Keywords(s):  
Category(s): Technology Classifications > Computer Science
Multi-List Strategy for Spectrum Interference Management
THE CHALLENGE Spectrum managers operating in shared-spectrum environments (e.g., the CBRS band) face a critical challenge: protecting high-priority incumbents such as Navy radar while maintaining reliable service for commercial users. Static move lists—the prevailing industry approach—repeatedly shut down the same base stations during...
Published: 11/17/2025   |   Updated: 7/16/2025   |   Inventor(s): Naru Jai, Yubo Wu, Yi Shi, Yiwei Thomas Hou
Keywords(s):  
Category(s): Technology Classifications > Communication
Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery
A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity. Background: Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...
Published: 1/29/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
Injectable Nanogel for Immune Modulation Therapy
A platform for effective therapeutic delivery and immune modulation for effective and quick inflammation control in critical illness, including sepsis. Background: Immune modulation therapy is a type of immunotherapy that enhances the body’s immune regulation and homeostasis. This therapy has proved promising for the treatment of some types...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion
This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice. Background: The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Lili Wang, Changying Shi
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Nanotechnology
Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...
Published: 6/12/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
Novel Nanocarrier for Systemic and Intracellular Delivery of Biological Therapeutics
Novel nanocarrier for systemic and intracellular delivery of biological therapeutics. Background: The stability and PK profile are of general concern for in vivo applications of many peptide/protein therapeutics. Poor stability of protein drugs can trigger immunogenicity. Furthermore, peptide and protein therapeutics mostly target extracellular receptors/signaling...
Published: 6/12/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Changying Shi, Lili Wang
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Telodendrimer Nanoparticles for Protein Delivery
A nanoparticle-based method for enhanced delivery of protein/peptide therapeutics. Background: Biologics, for example protein and peptide-based therapeutics, have poor in vitro shelf stability and in vivo enzymatic stability, which lead to short blood circulating time and contribute to immunogenicity. In addition, biologics are impermeable to biological...
Published: 6/12/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Xu Wang, Changying Shi, Alexa Bodman, Walter Hall
Keywords(s): cancer therapy, lipidoids, nanoparticles, protein delivery, telodendrimers
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Nanotechnology
1 2