Search Results - prostate+cancer

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Inhibitors of the N-terminal Domain of the Androgen Receptor (UCLA Case No. 2023-075)
Researchers at UCLA under the guidance of Drs. Matthew Rettig and Michael Jung have developed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...
Published: 9/23/2024   |   Inventor(s): Matthew Rettig, Michael Jung
Keywords(s): androgen receptor therapy, castration resistant prostate cancer, Oncology, Oncology (Small Molecules, Peptides and Antibodies), prostate cancer, small molecules
Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)
Bioinformatic Methods for Determining Resistance to Cancer Treatments
​ ​ Invention Summary: Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible. Researchers at Rutgers University have...
Published: 7/15/2024   |   Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
Temporal Transcriptomic Characterization of Small Cell Neuroendocrine Prostate Cancer (UCLA Case No. 2023-268)
The laboratory of Dr. Thomas Graeber at UCLA developed a novel in vivo model that can characterize mechanisms of the trans-differentiation of prostate cancer into small cell neuroendocrine cancer. BACKGROUND: Prostate cancer is one of the most common cancers among men worldwide, with an estimated 288,300 new cases in the U.S. last year. Among many...
Published: 7/10/2024   |   Inventor(s): Thomas Graeber
Keywords(s): neuroendocrine, Oncology, prostate cancer, small cell cancer, transdifferentiation
Category(s): Therapeutics > Oncology > Oncology (Small Molecules), Platforms > Diagnostic Platform Technologies
Human T-Cell Receptors Targeting Tumor-Enhanced Splicing Epitopes on HLA-A for Small Cell Carcinoma (UCLA Case Nos. 2023-117, 2020-817)
UCLA Researchers in the Department of Microbiology, Immunology, & Molecular Genetics have utilized their previously developed computational method (IRIS), to process and capture small cell carcinoma-specific RNA splicing events in small cell cancer. These events and associated epitopes were then used as the basis for generating new T cell receptors...
Published: 5/16/2024   |   Inventor(s): Owen Witte
Keywords(s): alternative splicing, Cancer, prostate cancer, RNA splicing, small cell, small cell cancer, small cell lung cancer, small cell prostate cancer, Targets And Assays
Category(s): Life Science Research Tools
Full Spectrum Computer Vision for Photon Counting CT (Case No. 2024-058)
Summary: Researchers in the Department of Radiological Sciences have developed a machine learning algorithm that processes multispectral photon counting CT data for accurate medical imaging. Background: Photon counting computed tomography (PCCT) is a tremendous engineering advancement, enabling high resolution spectral imaging with myriad applications....
Published: 9/20/2024   |   Inventor(s): Matthew Brown, Dieter Enzmann, John Hoffman, Michael Mcnitt-Gray
Keywords(s): AI algorithms, Algorithm, Algorithm Optical Coherence Tomography, algorithmic cancer detection, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, Artificial Neural Network Artificial Neuron, artificial-intelligent materials, Big Data, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, Cancer stem cells, cancer target, Computed tomography, CT, Deep Learning, design software, Digital Pathology, generative artificial intelligence, Genetic Algorithm, Histopathological image analysis, Histopathology, histopathology images, hyperparameter optimization, Image Analysis, Image Processing, lympathic cancers, lymphatic cancer, Medical artificial intelligence (AI), Mesenchymal Stem Cell Derived Cancer Cells, Orthotopic cancer models, Pancreatic cancer, pathology image analysis, Photon counting computed tomography (PCCT), prostate cancer, Radiology, Radiology / Radiomitigation, Software, Software & Algorithms, Software Development Tools, Software-enabled learning
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics
Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)
Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...
Published: 2/26/2024   |   Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee
Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells
Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Compounds that Interfere with the Androgen Receptor Complex
Abstract: Investigators at the National Institutes of Health (NIH) have discovered compounds that have potential as novel anti-androgen therapeutics. The immunophilin protein FKBP52 is part of a protein complex that helps fold the androgen receptor (AR) protein, a target for treating prostate cancer, and enhances its activity. Disruption of the FKPB52-AR...
Published: 4/8/2024   |   Inventor(s): Leonard Neckers, Jane Trepel Neckers, Yeong Kim, Aki Iwai, Yangmin Ning, Marc Cox, Johanny Meneses De Leon, Heather Balsiger, Robert Fletterick
Keywords(s): androgen receptor protein, DIABETES, PROSTATE CANCER
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology
Human T Cell Receptors for Treating Cancer
Abstract: T cell receptors (TCRs) are proteins that recognize antigens in the context of infected or transformed cells and activate T cells to mediate an immune response and destroy abnormal cells. TCRs consist of two domains, one variable domain that recognizes the antigen and one constant region that helps the TCR anchor to the membrane and transmit...
Published: 4/8/2024   |   Inventor(s): Richard Morgan, Nachimuthu Chinnasamy, Steven Rosenberg
Keywords(s): COLON CANCER, Hepatocellular cancer, MELANOMA, PROSTATE CANCER, SSX
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Multi-epitope Vaccines against TARP (ME-TARP) for Treating Prostate and Breast Cancer
Abstract: The development of more targeted means of treating cancer is vital. One option for a targeted treatment is the creation of a vaccine that induces an immune response only against cancer cells. In this sense, vaccination involves the introduction of a peptide into a patient that causes the formation of antibodies or T cells that recognize the...
Published: 4/8/2024   |   Inventor(s): Lauren Wood, Jay Berzofsky, Brenda Roberson, Masaki Terabe
Keywords(s): BREAST CANCER, CANCER VACCINE, Immunotherapy, PROSTATE CANCER
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines
Aryl Hydantoin Heterocycle Compounds that Target the Androgen Receptor for Prostate Cancer Treatment
Abstract: Prostate cancer is the most prevalent form of cancer among all men in the United States (US). It is also the second leading cause of cancer-related deaths in the US among men, largely due to the progressively treatment resistant nature of the disease. Treatment options for early stage prostate cancer include watchful waiting, radical prostatectomy,...
Published: 4/8/2024   |   Inventor(s): Berkley Gryder, Adegboyega Oyelere, Eric Raftery, Subhasish Tapadar, Nicholas Aboreden, William Figg
Keywords(s): Androgen Deficiency Disorders, Androgen dysfunctional Disorders, Androgen Receptor, Androgen Receptor Inverse Agonists, Anti-androgens, AR, ARIA, BREAST CANCER, Georgia Institute of Technology, GIT, Gryder, Hyperandrogenism, PROSTATE CANCER
Category(s): Application > Therapeutics, TherapeuticArea > Endocrinology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
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