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Search Results - autoimmunity
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Mice, Organs, and Mouse Alleles Carrying Germline and Conditional Deletions of the Zbtb7b Gene
Abstract: The Zbtb7b gene encodes the zinc finger transcription factor ThPOK (also known as cKrox) that promotes CD4 lineage differentiation in immature T cells. CD4+ T cells, also known as “helper” T cells, are critical for long-term immunity against pathogens as well as for promoting CD8+ “effector” T cell and effective B cell responses. ThPOK is...
Published: 5/8/2024
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Inventor(s):
Keywords(s):
Autoimmunity
,
Bosselut
,
CANCER
,
CD4
,
cKrox
,
Helper T Cell
,
Infection
,
LYMPHOCYTE
,
Memory T Cell
,
Oncology
,
ThPOK
,
transgenic mice
,
Zbtb7b
,
Zinc Finger Transcription Factor
Category(s):
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Research Materials
,
TherapeuticArea > Immunology
IL7Rα-Specific Antibody for Treating Acute Lymphoblastic Leukemia (ALL)
Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in children with approximately 3,250 new cases occurring per year in the United States. About 20% of cases are refractory to current treatment protocols and there is a desperate need for targeted therapies that do not result in adverse side effects such as cognitive impairment. The...
Published: 4/8/2024
|
Inventor(s):
Scott Durum
,
Julie Hixon
,
Wenqing Li
,
Scotch Walsh
,
Lila Kashi
Keywords(s):
Acute lymphoblastic leukemia (ALL)
,
ANTIBODY
,
Antibody-Dependent Cellular Cytotoxicity (ADCC)
,
Autoimmunity
,
CANCER
,
DIABETES
,
Durum
,
Interleukin-7 receptor-α (IL-7Rα)
,
Multiple sclerosis
,
personalized medicine
,
Targeted therapy
,
THERAPY
,
TRANSPLANTATION
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration