Search Results - neurologic+disease

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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases. BACKGROUND Neurodegenerative disorders such as...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators
✅ Feedback form for Tech ID 2015-064 PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators NU 2015-064 INVENTORS Richard Silverman* Dimitri Krainc Jianbin Zheng SHORT DESCRIPTION Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
Development of Therapeutics for Amyotrophic Lateral Sclerosis (ALS)
NU 2008-163 and NU2009-098 Inventors Richard B. Silverman* Richard Morimoto P. Hande Ozdinler Short Description Three series of New Chemical Entities (NCEs) that exhibit efficacy in an ALS animal model Background ALS causes muscle weakness and atrophy due to the degeneration of the upper and lower motor neurons. This disease is both genetic...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179 INVENTORS Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry) Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience) Garry Cooper Soosung Kang Jack Nguyen SHORT DESCRIPTION For pharmaceutical...
Published: 11/11/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
A Biological Marker for Concussion
NU 2016-016 INVENTORS Nina Kraus* Trent Nicol Travis White-Schwoch SHORT DESCRIPTION This technology provides a method for objectively identifying non-penetrating brain injuries by analyzing the brain’s frequency following response (FFR) to an acoustic stimulus. It offers a non-invasive alternative that improves diagnostic precision and...
Published: 11/7/2025   |   Inventor(s):  
Keywords(s): Biomarker, Brain injury, Devices, Diagnostics, Electrophysiology, Health IT, Medical device, Neurologic disease, Research tool
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149 INVENTORS Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)* Daniel Galtieri Ema Ilijic Enrico Zampese Jaime Guzman-Lucero Javier Sanchez SHORT DESCRIPTION This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic
NU 2016-019 INVENTORS Dimitri Krainc* Michael Schwake SHORT DESCRIPTION LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease BACKGROUND Mutations in glucocerebrosidase (GCase) cause Gaucher Disease. Additionally, GCase mutations are a major risk factor in Parkinson’s Disease,...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
A new CNS-available formulation HDACi for management of chronic pain
A new CNS-available formulation HDACi for management of chronic pain NU 2017-031 INVENTORS Vania A. Apkarian* Kasturi Haldar Maria V. Centeno Suhail Alam SHORT DESCRIPTION A novel non-opioid, epigenetic drug for pain relief BACKGROUND Chronic pain is a major public health problem, and it is the number one source of disability in the...
Published: 11/11/2025   |   Inventor(s):  
Keywords(s): Biomedical, Chronic pain, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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