Search Results - neurologic+disease

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LIMP-2 based activation of Glucocerebrosidase
A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic NU 2016-019 INVENTORS Dimitri Krainc* Michael Schwake SHORT DESCRIPTION LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease BACKGROUND Mutations in glucocerebrosidase...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
A new CNS-available formulation HDACi for management of chronic pain
A new CNS-available formulation HDACi for management of chronic pain NU 2017-031 INVENTORS Vania A. Apkarian* Kasturi Haldar Maria V. Centeno Suhail Alam SHORT DESCRIPTION A novel non-opioid, epigenetic drug for pain relief BACKGROUND Chronic pain is a major public health problem, and it is the number one source of disability in the...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomedical, Chronic pain, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Humanized antibody targeting the tumor associated antigen, IL13Ra2
Humanized antibody targeting the tumor associated antigen, IL13Ra2 NU 2020-031 INVENTORS Irina Balyasnikova* SHORT DESCRIPTION A novel antibody that specifically targets glioblastoma cells BACKGROUND Glioblastoma is a deadly, incurable disease with a low 5 year survival rate. The current standard of care typically involves surgical resection...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Antibody, Cancer/Oncology, CAR T, Cell therapy, Gene therapy, Neurologic disease, Personalized medicine, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
Pharmacotherapy for Preventing Neurodegeneration
NU 2016-108 INVENTORS D. James Surmeier* Steven M. Graves SHORT DESCRIPTION Small molecule therapeutics to prevent neurological degeneration associated with other pharmaceutical treatments ABSTRACT Methamphetamine and amphetamine are pharmaceutical drugs sometimes used to treat attention definicity hyperactive disorder (ADHD), obesity, and narcolepsy....
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Infrared Tele-Video-Oculography for Remote Evaluation of Eye Movements
NU 2020-085 INVENTORS Marcello Cherchi* ABSTRACT Observation of eye movements is essential in the diagnosis, monitoring and management of a broad range of vestibular disorders, that is diseases affecting balance. Ideally, this examination should be conducted so that the patient’s eye movements can be examined under specific circumstances: (1)...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Artificial Intelligence & Machine Learning, Bioinformatics, Computer software, COVID-19, Data processing/analysis, Devices, Neurologic disease, Ophthalmic disease, Remote Monitoring, Virtual Reality/Augmented Reality
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Deep Learning Structural Analysis Of Cerebral Cortex Predicts Features From MRI Data
NU 2020-152 INVENTORS Pierre Alain Besson S. Kathleen Bandt* SHORT DESCRIPTION Graph convolutional neural networks (gCNNs) successfully predict patient age and sex from T1-weighted brain surface MRI data. BACKGROUND As clinical image-based data sets grow in resolution and size, the promise of machine learning greatly expedites image classification...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Artificial Intelligence & Machine Learning, Computer software, Data processing/analysis, Image/Signal processing, Neurologic disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Fluorescence and Magnetic Resonance Detectable Retrograde Neuronal Tracers
NU 2020-029 INVENTORS Nathan Gianneschi* Massimo Scanziani (UCSF) SHORT DESCRIPTION Novel polymeric nanoparticle neuronal tracers with a range of fluorophores for multiplexed in vivo brain mapping. ABSTRACT Northwestern researchers have developed novel latex particles for retrograde neuronal tracing as a critical tool for the mapping of brain architecture....
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Imaging, Nanoparticle, Neurologic disease, Research tool
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Development of Neuroprotective Therapeutics Based on Stroke-Induced Secretory Proteins
NU 2010-125InventorShu Q. LiuShort Description A biologic for neuroprotection during the acute phase of a strokeBackgroundStroke is the leading cause of serious, long-term disability in the United States. As adult neurons possess a limited capacity for protection and regeneration, infarcted brain tissue is often replaced with fibrotic tissues, resulting...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biologic, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Nanostructures for Diagnosis and Therapy of Alzheimer's Disease
NU 2009-169 Inventors Vinayak Dravid* Saurabh Sharma Kristen Viola William Klein* Short Description Novel magnetic nanostructures that recognize toxic beta-amyloid protein oligomers responsible for Alzheimer's disease progression Abstract Northwestern University researchers have developed a new magnetic nanostructure that can be used to detect and...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomarker, Devices, Diagnostics, Health IT, Medical device, Nanoparticle, Neurodegenerative disease, Neurologic disease, Research tool, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Biodegradable, Drug-Releasing Tubes For Tissue Engineering and Regeneration
NU 2003-091 Inventors Jae-Hyung Jang Laura De Laporte Christopher B Rives Mark A Rovedo Lonnie David Shea* Kevin J Whittlesey Yang Yang Abstract Investigators at Northwestern have designed biodegradable nerve guidance conduits or bridges possessing multiple features for promoting nerve regeneration including the ability to deliver DNA, protein,...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomedical, Devices, Drug delivery, Health IT, Materials, Medical device, Neurologic disease, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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