Search Results - cancer+treatment

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Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment
­Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...
Published: 9/3/2024   |   Inventor(s): Lianchun Wang
Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel Peptide-Based Inhibitors of HIF-1α for Cancer Therapy
­Advantages: Developed helical mimetics of HIF-1α based on sulfonyl-γ-AA peptides that selectively target HIF-1α to target metastasis and therapy resistance in solid tumors. Inhibitors are stable and cell permeable. HC11, HC13, and HC14 sulfonyl-γ-AA peptides efficiently inhibit HIF-1α activity and reduce expression...
Published: 9/3/2024   |   Inventor(s): Jianfeng Cai, Sami Abdulkadir
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology
Targeting CREB-Heparan Sulfate Pathway for Cancer Treatment
­Advantages: This research contributes to a better understanding of the molecular mechanisms underlying the development and progression of PCa. The study identifies a specific signaling pathway involving Pten loss, CREB, and HS that plays a crucial role in promoting prostate tumorigenesis. The study explores potential therapeutic interventions,...
Published: 9/19/2024   |   Inventor(s): Hua Yang, Lianchun Wang
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
SHIP-1 Agonists for Pancreatic Cancer Treatment
­Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio includes...
Published: 6/11/2024   |   Inventor(s): Tomar Ghansah
Keywords(s): Biotechnology, Cancer Treatment, Diagnostics
Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Medical Diagnostics
SHIP-1: Biomarker and Therapeutic Target to Reduce Health Disparities in African Americans with Pancreatic Cancer
­Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio included...
Published: 6/11/2024   |   Inventor(s): Tomar Ghansah
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Oncology
Physiologic Modeling of Multiphase Intra-Arterial CT Angiography for Hepatic Embolization Therapy
­Advantages: Optimized Dosage Delivery Real-time Treatment Monitoring Personalized and Enhanced Treatment Plans Summary: The market demand for Yttrium-90 radioembolization (RE) has grown significantly over the past decade as a crucial transcatheter intraarterial therapy for patients with unresectable liver cancer. To enhance the effectiveness...
Published: 8/16/2024   |   Inventor(s): John Mayfield, Ghassan El-Haddad, Jonathan Ford
Keywords(s): Cancer Treatment, Medical Imaging, Oncology
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Data/AI > D/AI Imaging, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Computer Science > Computers Software & Information Technology
MLKL Polymerization-Induced Lysosome Membrane Permeabilization Drives Necroptotic Cell Death
­Advantages: Novel Drug Targets: Technology identifies MLKL polymerization-induced LMP as a promising target for innovative medications. Advancing Precision Medicine: Isolated lysosomes with activated p-MLKL and MLKL offer resources for personalized treatments. Early Disease Detection: Live-cell imaging enables timely identification of necroptosis-related...
Published: 8/22/2024   |   Inventor(s): Preston Perez, Zhigao Wang
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics
RNA Aptamer Targeting of ADAM8 in the Tumor Microenvironment
­Advantages: Novel targeted RNA aptamers to inhibit ADAM8 and block cancer associated fibroblast maintenance in the tumor microenvironment. RNA aptamer benefits: high affinity, high specificity, and low immunogenicity Promising preclinical in vitro and in vivo outcomes Summary: This research delves into the intricate dynamics of cancer progression,...
Published: 5/20/2024   |   Inventor(s): Paul Kuo, Zhiyong Mi
Keywords(s): Cancer Treatment, Medical Therapeutics Cell Therapy, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering
Novel Biologic Inhibitors to Target Doxorubicin-Induced Cardiomyopathy
­Advantages: Biologics (peptidomimetic inhibitors) that prevent Doxorubicin-induced cardiomyopathy (DIC) that can occur with cancer chemotherapy Peptide therapeutics have high specificity, potency, and low toxicity when compared to traditional small molecule drugs Potentially enabling cancer patients to receive DOX treatment without compromising...
Published: 8/22/2024   |   Inventor(s): Xueling Ma
Keywords(s): Biotechnology, Cancer Diagnostics, Cancer Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Oncology
Heteromers Between Chemokine Receptors And Alpha1-Adrenergic Receptors/Vasopressin Receptor 1A As Drug Targets To Modulate Inflammation And Cell Trafficking
­Advantaages: Novel therapeutic opportunities for modulating inflammation and cell trafficking Insights into neuroendocrine control of immune cell behavior Summary: This innovative technology centers around the discovery and characterization of heteromers formed between chemokine receptors (CR) and a1-adrenergic receptors (AR), specifically...
Published: 6/20/2024   |   Inventor(s): Matthias Majetschak
Keywords(s): Cancer Treatment, Therapeutics Cell Therapy
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics
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