Search Results - cancer+treatment

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Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 4/30/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Novel HPV Epitopes for Designing Cervical Cancer Immunotherapies
Advantages: Specific targeting of HPV epitopes from E2 and E6 proteins opens new avenues for cervical cancer immunotherapies. Correlation of high chemical complementarity scores between TCR CDR3 regions and HPV epitopes with improved overall and disease-free survival provides a reliable biomarker that complement traditional clinical factors. Whole...
Published: 4/24/2025   |   Inventor(s): George Blanck, Deo Rei Agnila, Rahul Jain, Michael Diaz, Tabitha Hudlock, Rachel Eakins, Andrea Chobrutskiy, Boris Chobrutskiy
Keywords(s): Biomarker, Cancer Treatment, Women’s Health
Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Womens Health
Novel Potential Treatment for Glioblastoma Multiforme (GBM) via Potent Inhibitor of Atypical Protein Kinase C-iota
Advantages: ICA-1S uniquely inhibits aPKC-ι and Connexin 43, critical proteins in Glioblastoma Multiforme progression Significantly reduces glioblastoma cell proliferation, demonstrating superior efficacy compared to current chemotherapy agents Overcome therapeutic resistance by targeting Connexin 43, enhancing responsiveness to treatment Addressing...
Published: 3/25/2025   |   Inventor(s): Mildred Acevedo-Duncan, Grazielly Teodoro
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Multiphasic Localized in vivo Molecular Delivery
Advantages: Asymmetric biphasic pulses significantly reduced stimulation of skeletal muscle contractions in vivo and enhanced gene delivery Enables delivery of insulin and glucokinase to replace daily injections with long-term, non-immunogenic protein expression in skeletal muscle Higher-efficiency gene therapies avoid immunogenicity and off-target...
Published: 2/21/2025   |   Inventor(s): Anna Bulysheva, Mark Jaroszeski, Richard Heller
Keywords(s): Cancer Treatment, Drug Delivery Systems, Medical Therapeutics Gene Therapy, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Cancer, Technology Classifications > Medical > Biomedical Engineering
Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes
Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...
Published: 2/12/2025   |   Inventor(s): Timothy Yeatman, Mingli Yang
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry
Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment
­Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...
Published: 11/25/2024   |   Inventor(s): Lianchun Wang
Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel Peptide-Based Inhibitors of HIF-1α for Cancer Therapy
­Advantages: Developed helical mimetics of HIF-1α based on sulfonyl-γ-AA peptides that selectively target HIF-1α to target metastasis and therapy resistance in solid tumors. Inhibitors are stable and cell permeable. HC11, HC13, and HC14 sulfonyl-γ-AA peptides efficiently inhibit HIF-1α activity and reduce expression...
Published: 9/3/2024   |   Inventor(s): Jianfeng Cai, Sami Abdulkadir
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology
Targeting CREB-Heparan Sulfate Pathway for Cancer Treatment
­Advantages: This research contributes to a better understanding of the molecular mechanisms underlying the development and progression of PCa. The study identifies a specific signaling pathway involving Pten loss, CREB, and HS that plays a crucial role in promoting prostate tumorigenesis. The study explores potential therapeutic interventions,...
Published: 1/31/2025   |   Inventor(s): Hua Yang, Lianchun Wang
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
SHIP-1 Agonists for Pancreatic Cancer Treatment
­Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio includes...
Published: 4/21/2025   |   Inventor(s): Tomar Ghansah
Keywords(s): Biotechnology, Cancer Treatment, Diagnostics
Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Medical Diagnostics
SHIP-1: Biomarker and Therapeutic Target to Reduce Health Disparities in African Americans with Pancreatic Cancer
­Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio included...
Published: 4/21/2025   |   Inventor(s): Tomar Ghansah
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Oncology
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