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Hydrophilic Asn-Asn-Linker Adcs for Potent and Stable Targeted Immunotherapy
This invention introduces hydrophilic TLR7 agonist antibody drug conjugates using a short Asn Asn linker that improves solubility, stability, and pharmacokinetics. By enabling precise site specific conjugation with reduced aggregation and strong innate immune activation, the platform delivers potent antitumor responses across multiple solid tumor indications. Background:...
Published: 11/14/2025
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Inventor(s):
Lawrence Tumey
,
Mohan Mullapudi
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Dual Payload Antibody Conjugates for Combined Cytotoxic and Immune Stimulatory Cancer Therapy
This invention introduces a dual payload antibody drug conjugate platform that delivers both a potent cytotoxic agent and a TLR7 agonist to tumors with controlled, site specific attachment. By uniting targeted cell killing with localized immune activation in a single biologic, the approach improves therapeutic index, overcomes resistance, and enhances...
Published: 11/14/2025
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Inventor(s):
Lawrence Tumey
,
Victor Ojo
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Enzymatic Bioluminescent Beacons for Ultra-Sensitive, Rapid Nucleic Acid Detection
This invention introduces enzymatic bioluminescent beacons that generate bright, low-background light only upon binding their target sequence. A site-specific ligation strategy forms uniform 1 to 1 nanoluciferase–hairpin conjugates, enabling rapid, picomolar sensitivity detection with precise single-base discrimination in streamlined, equipment-light...
Published: 11/14/2025
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Inventor(s):
Brian Callahan
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Self-restructuring platinum ternary nanoalloys for durable low temperature exhaust oxidation
This invention introduces self-restructuring platinum-based ternary nanoalloy catalysts that maintain high oxidation activity after hydrothermal aging. By alloying Pt with two transition metals, the catalyst delivers durable low-temperature exhaust oxidation with reduced precious metal use, supporting efficient CO, hydrocarbon, and NO oxidation for...
Published: 11/12/2025
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Inventor(s):
Chuan Jian Zhong
,
Shiyao Shan
,
Shan Wang
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Ultra-compact Single-stage 48 V-to-Sub-1 V Converter with Adaptive Soft-switch Control
This invention presents a single-stage half-bridge converter that efficiently converts 48 V to sub-1 V using adaptive soft-switching control. By combining quasi-peak cycle-by-cycle current regulation with sensorless droop control, it achieves high efficiency, compact design, and rapid transient response for next-generation data-center, telecom, and...
Published: 11/12/2025
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Inventor(s):
Tuhin Sasmal
,
Pritam Das
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Room-Temperature Silver-Copper Nanoalloy Inks for Low-Cost Flexible Electronics
This invention introduces silver-copper (AgCu) nanoalloy inks and pastes that sinter at room temperature, enabling low-cost, flexible, and energy-efficient printed electronics. The formulation maintains high conductivity, resists oxidation, and can be printed on heat-sensitive substrates like paper, polymers, and textiles without external heating, supporting...
Published: 11/12/2025
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Inventor(s):
Chuan Jian Zhong
,
Richard Robinson
,
Shan Wang
,
Shan Yan
,
Guojun Shang
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Advanced Matrix Transformer Architecture for High-Efficiency 48V-to-Sub-1V Power Conversion
This invention introduces an advanced four-pillar matrix transformer architecture that doubles magnetizing inductance, reduces core volume, and minimizes circulating currents for compact, high-efficiency 48 V-to-sub-1 V conversion. Its optimized diagonal core geometry and parallel winding design improve thermal balance and efficiency, enabling scalable...
Published: 11/12/2025
|
Inventor(s):
Tuhin Sasmal
,
Pritam Das
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Soft hydrogel CNT microelectrodes for stable long term biointerfaces
This invention introduces soft, stretchable hydrogel microelectrodes reinforced with aligned carbon nanotubes (CNTs) to achieve tunable anisotropic conductivity and compliant mechanics. The system maintains low-impedance electrical performance during deformation while enabling integrated optical and microfluidic functionality for next-generation biointerfaces...
Published: 11/12/2025
|
Inventor(s):
Siyuan Rao
,
Qianbin Wang
,
Sizhe Huang
,
Ruobai Xiao
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Portable Wireless VOC Analyzer for Health and Environmental Monitoring
This invention presents a compact, wireless air sampling system that detects volatile organic compounds (VOCs) using nanostructured gold nanoparticle sensor arrays. Integrating low-power electronics, environmental compensation, and onboard machine learning, it enables real-time, remote VOC analysis for environmental and health diagnostics, with applications...
Published: 11/12/2025
|
Inventor(s):
Chuan Jian Zhong
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
Drill Center Guide
This simple tool is an inexpensive, easy to use drill bit guide for drilling accurately centered holes with drill presses or mills. Background: When using a drill press or mill, it can be a significant challenge to drill accurately centered holes quickly without using some type of centering jig. The primary way to avoid this requires a special...
Published: 10/24/2025
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Inventor(s):
Neil Haney
Keywords(s):
Technologies
Category(s):
Campus > SUNY Canton
,
Technology Classifications > Engineering
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