Search Results - renal

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New Fusion Molecule Based on Novel TAA Variant (UCLA Case No. 2007-217)
BACKGROUND: Renal cell carcinoma (RCC) affects approximately 39,000 Americans and causes an estimated 13,000 deaths per year. Metastatic RCC poses a therapeutic challenge because of its resistance to conventional modes of therapy. Approximately one third of RCC patients will present at the metastatic stage and one third of patients with localized disease...
Published: 2/16/2024   |   Inventor(s): Arie Belldegrun, Zhenhua Li
Keywords(s): Cancer, Immunotherapy, Renal, Renal cell carcinoma, renal diseases
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Renal
Mouse Model for Methylmalonic Acidemia, an Inherited Metabolic Disorder
Methylmalonic Acidemia (MMA) is a metabolic disorder affecting 1 in 25,000 to 48,000 individuals globally. MMA is characterized by increased acidity in the blood and tissues due to toxic accumulation of protein and fat by-products resulting in seizures, strokes, and chronic kidney failure. About 60% of MMA cases stem from mutations in the methylmalonyl...
Published: 7/25/2024   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Dysfunction, metabolic disorder, Methylmalonic acidemia, Methylmalonyl-CoA, methylmalonyl-CoA mutase, MITOCHONDRIAL, MMA, Model, Mouse, MUT, RENAL, RXXXXX, TRANSGENIC, transgenic mouse, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials
Agonist Epitopes for Renal Cell Carcinoma
Approximately 30,000 patients are diagnosed with renal cell carcinoma (RCC) each year in the United States, and an estimated 12,000 patients die of this disease. Most patients are diagnosed with advanced local disease or metastatic disease. Metastatic RCC carries a poor prognosis with median survivals in the range of 10-12 months. Drugs that inhibit...
Published: 7/25/2024   |   Inventor(s): Richard Childs
Keywords(s): BBXXXX, CA1AXX, CA1XXX, CA2CXX, CA2XXX, Carcinoma, CAXXXX, CB2BXX, CB2XXX, CB4XXX, CBXXXX, Cell, Cells, CXXXXX, Discovery, Expression, Gene, Kidney cancer, adult, Patent Category - Biotechnology, previously, RDD, RENAL, Renal cell carcinoma 1, Renal cell carcinoma 4, Restricted, Uncharacterized, WHOSE
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Oncology
2020-859-1 Novel Approach to Modulate Renal Neurotransmission via Percutaneous
SUMMARY: UCLA researchers in the Department of Medicine-Cardiology have developed a method that applies renal denervation to specific renal arteries to treat resistant hypertension. BACKGROUND: Sympathetic nervous system activation occurs when chemicals, such as adrenaline, bind to multiple receptors that are responsible for vital functions such...
Published: 8/2/2023   |   Inventor(s): Olujimi Ajijola
Keywords(s): Artery, Blood Pressure, Hypertension, Hypertension Urine, Kidney, Medical Device, Renal, Surgery
Category(s): Life Science Research Tools, Diagnostic Markers, Medical Devices
Rapid screening tool to detect early-stage diabetes
New device with potential to improve diabetes care and management for millions of patients Problem The CDC estimates that approximately 7 million people in US have diabetes and don't know it.1 Delayed diagnosis increases the risk of serious complications such as premature heart disease, stroke, and kidney failure.2 Accurate screening tools that fit...
Published: 11/1/2023   |   Inventor(s): Yuebing Zheng, Kumar Sharma, Yaoran Liu, Zilong Wu
Keywords(s): Biomarkers, Chemical analysis, Diabetes, Diagnostics, Instrumentation, Photonics, Point-of-care, Renal
Category(s): Life sciences > Diagnostic
SYNERGISM BETWEEN PROTON PUMP INHIBITORS AND A GI PEPTIDE IN REDUCING ACID SECRETION
Case 2000-093UCLA researchers in the Department of Medicine have discovered a novel method to improve the efficacy of proton pump inhibition. BACKGROUND:A vast number of pathological conditions are characterized by over-secretion of gastric acid, such as Zollinger/Ellison syndrome (ZES), gastroesophageal reflux disease (GERD), peptic ulcer disease,...
Published: 7/19/2023   |   Inventor(s): Joseph Pisegna
Keywords(s): Gastroenterology & Digestive Disease, Renal, Therapeutics & Vaccines
Category(s): Therapeutics > Gastroenterology, Therapeutics > Renal
Smart Dialysis Catheter
UC Case No. 2019-873SUMMARY:UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.BACKGROUND:Kidney failure currently affects 660,000 Americans. 468,000 of these individuals...
Published: 7/19/2023   |   Inventor(s): Asim Rafique
Keywords(s): Bioinformatics, Cardiovascular, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Health, Hospital Systems And Devices, Medical Devices and Materials, Metabolic Diseases, Monitoring And Recording Systems, Renal, Urology
Category(s): Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular
2017-443 Small Molecule Inhibitors of Cardiovascular and Renal Ectopic Calcification
Small Molecule Inhibitors of Cardiovascular and Renal Ectopic CalcificationSUMMARYUCLA researchers in the Department of Medicine have discovered that administration of small molecule inhibitors of ENPP1 or functional antagonists of PPi can substantially attenuate ectopic calcification. This suggests that ENPP1 and PPi can be potential pharmacological...
Published: 7/19/2023   |   Inventor(s): Arjun Deb
Keywords(s): Cardiovascular, Renal, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Renal
2004-084 Adipose Derived Stem Cells for Reconstruction of the Urinary Tract
Stem Cell Urinary Tract Reconstruction TherapySUMMARYResearchers from the UCLA Department of Urology have successfully harvested stem cells from adipose tissue and differentiate them into functioning smooth muscle cells. These adipose derived stem cells can then be used for reconstruction or tissue engineering of smooth muscle containing organs, especially...
Published: 7/19/2023   |   Inventor(s): Benjamin Wu, Larissa Rodriguez
Keywords(s): iPS/stem cells, Renal, Stem Cells / Regenerative Medicine, Urology
Category(s): Therapeutics > Urology, Therapeutics > Renal, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
MUSC Other Therapeutics
MUSC Other Therapeutics: Novel Biofabrication Techniques for the Implementation of Intrinsic Tissue Geometries to an In Vitro Collagen Hydrogelhttp://musc.technologypublisher.com/technology/17788 Targeted Rapamycin Micelle (TRaM) as a Therapeutic in Solid Organ Transplanthttp://musc.technologypublisher.com/technology/14993 Use of Double Stranded...
Published: 2/7/2023   |   Inventor(s):  
Keywords(s): autoimmune, infectious, inflammation, renal, veterinary
Category(s): BioPharma
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