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Cannabinoid Receptor Meditating Compounds for Metabolic Disease
There is evidence that the metabolic effects of endocannabinoids are mediated by CB1 receptors in peripheral tissues. While prior attempts at generating CB1 receptor blockers have had serious neuropsychiatric side effects, inventors at NIH have discovered compounds that block CB1 receptors with reduced brain penetrance. In addition, some of these...
Published: 10/28/2024   |   Inventor(s): Malliga Iyer, Resat Cinar, Kenner Rice, George Kunos
Keywords(s): 4, 5-Dihydro-1H-Pyrazole, Derivatives, IB6XXX, IBXXXX, Peripherally, Restricted, VFXXXX, VHXXXX, WKXXXX, YAXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Reproductive Health
Agonist Epitopes for Renal Cell Carcinoma
Approximately 30,000 patients are diagnosed with renal cell carcinoma (RCC) each year in the United States, and an estimated 12,000 patients die of this disease. Most patients are diagnosed with advanced local disease or metastatic disease. Metastatic RCC carries a poor prognosis with median survivals in the range of 10-12 months. Drugs that inhibit...
Published: 10/28/2024   |   Inventor(s): Richard Childs
Keywords(s): BBXXXX, CA1AXX, CA1XXX, CA2CXX, CA2XXX, Carcinoma, CAXXXX, CB2BXX, CB2XXX, CB4XXX, CBXXXX, Cell, Cells, CXXXXX, Discovery, Expression, Gene, Kidney cancer, adult, Patent Category - Biotechnology, previously, RDD, RENAL, Renal cell carcinoma 1, Renal cell carcinoma 4, Restricted, Uncharacterized, WHOSE
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Oncology