Search Results - cells

33 Results Sort By:
Minibody for Conditioning prior to Hematopoietic Stem Cell and Progenitor Cell Transplantation
Patient conditioning is a critical initial step in hematopoietic stem and progenitor cell (HSPC) transplantation procedures to enable marrow engraftment of infused cells. Conditioning regimens have traditionally been achieved by delivering cytotoxic doses of chemotherapeutic agents and radiation. However, these regimens are associated with significant...
Published: 10/28/2024   |   Inventor(s): Daisuke Araki, Diogo Magnani, Zhirui Wang, Andre Larochelle
Keywords(s): 1CXXXX, 2IXXXX, 2JXXXX, Anti-cMPL, Cells, DEPLETION, Divalent, DT-390-Conjugated, hematopoietic, Progenitor, ScFv, Stem, VCXXXX, VPXXXX, WJXXXX, WMXXXX, XAXXXX
Category(s): TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies
Use of beclin 1 Inhibitors, including 17-hydroxy Wortmannin, to Treat TRAIL-resistant Cancer
This technology includes the use of a beclin 1 inhibitor, 17-hydroxy Wortmannin, for the treatment of TRAIL-resistant colon cancer. TRAIL (TNF-related apoptosis-inducing ligand) binds to death receptors (DR4/DR5) and activates apoptosis in cancer cells. Multiple clinical trials have focused on promoting TRAIL-induced death but have had a lack of efficacy...
Published: 10/28/2024   |   Inventor(s): Sheng Dai, Wei Zheng
Keywords(s): 1, 17-hydroxy, Autophagy, Beclin, CANCER, Cells, COLON, Increased, Inhibitions, Overcomes, Resistance, TRAIL, VCXXXX, WIXXXX, WKXXXX, Wortmannin, XEXXXX
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Application > Therapeutics
Potentiating Antibody Therapy by Targeting Complement Deposited on Cancer Cells
Monoclonal antibodies (mAbs) have become a mainstay of therapy for many cancers. However, antibody therapy is not completely effective in some applications due to loss of the target surface antigen on cancer cells. Such mAb-induced “escape variants” are no longer sensitive to the therapeutic mAb therapy. It was observed that the escape variants carried...
Published: 10/28/2024   |   Inventor(s): Martin Skarzynski, Margaret Lindorfer, Ronald Taylor, Christoph Rader, Berengere Vire, Erika Gaglione, Haiyong Peng, Sivasubramanian Baskar, Adrian Wiestner
Keywords(s): 2JXXXX, 4GXXXX, 5OXXXX, ANTIBODY, C3, C3d, CANCER, CB1XXX, Cell, Cells, Complement, Deposited, Listed LPM Vathyam as of 4/15/2015, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Potentiating, Pre LPM working set 20150418, Protein, Surface, Targeting, THERAPY, THEROF, VCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology
Tumor Associated Calcium Signal Transducer 2 (TACSTD2)-Overexpressing Huh7.5 Cells That Are More Permissive to HCV Cell Entry and Replication Compared to the Model Huh7.5 Cell Line
Worldwide, 130-150 million individuals are chronically infected with hepatitis C virus (HCV), a major cause of liver-associated morbidity and mortality worldwide. Despite recent advances in antiviral drugs that can cure some individuals, a rapid decline of the global disease burden is hampered by remarkably high treatment costs and a high number of...
Published: 10/28/2024   |   Inventor(s): Vandana Sekhar, Patrizia Farci
Keywords(s): 2, Associated, CALCIUM, Cells, Huh7.5, Signal, TACSTD2-overexpressing, TRANSDUCER, tumor
Category(s): Collaboration Sought > Licensing
Epstein-Barr Virus Antibody That Blocks Fusion And Neutralizes Virus Infection of B Cells
Epstein-Barr virus (EBV) is the most common cause of infectious mononucleosis and is associated with nearly 200,000 cancers and 140,000 deaths each year. EBV-associated cancers include Hodgkin's lymphoma, non-Hodgkin's lymphoma, Burkitt B cell lymphoma, and EBV post-transplant lymphoproliferative disease. The latent reservoir for EBV in the body is...
Published: 10/28/2024   |   Inventor(s): Wei Bu, Nathan Board, Kennichl Dowdell, Jeffrey Cohen
Keywords(s): ANTIBODY, B, BLOCKS, Cells, DAXXXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DCXXXX, DDXXXX, DXXXXX, EPSTEIN-BARR, Fusion, Infection, Neutralizes, That, virus
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease
A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells
Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...
Published: 10/28/2024   |   Inventor(s): Qi Zhang, Yihong Ye
Keywords(s): Cells, HEPARAN, Label, MAMMALIAN, MEMBRANE, Method, PLASMA, PROTEOGLYCAN, R1XXXX, SULFATE, XCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials
Regenerative Therapy for Cartilage Damage
The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative...
Published: 12/26/2024   |   Inventor(s): Mitchell Shirvan, Rafael Gorodetsky, Sergei Kuznetsov, Astar Lazmi-Hailu, Pamela Robey
Keywords(s): Bone, Cartilage, Cells, Fibrin, Generation, Human, Hyaline, Marrow, Microbeads, STABLE, Stromal, TRANSPLANTATION, VAXXXX, Vivo, WJXXXX, XCXXXX, XDXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Application > Diagnostics, Application > Research Materials, Application > Non-Medical Devices, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Medical Devices
Regulator of G Protein Signaling (RGS13) Knock-Out Mouse
RGS13, an intracellular protein in mast cells, was shown to suppress IgE-mediated anaphylactic response in mice. The RGS13-/- mouse may be used to screen compounds that inhibit mast cell degranulation.
Published: 10/28/2024   |   Inventor(s): Zhi Hui (Sherry) Xie, Kirk Druey
Keywords(s): Anaphylactic, Cells, IGE-MEDIATED, Intracellutar, Knockout, Listed LPM Maddox as of 4/15/2015, MAST, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, RESPONSE, RGS13, RM, RXXXXX, Suppresses, That, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Adaptor for Suspending a Cryovial Over a Centrifuge Tube
The invention pertains to a device and system for expediting the thawing of frozen specimens (e.g., cryopreserved cells) contained in cryo-vials. An adaptor support suspends cryo-vials over a centrifuge tube containing culture medium in an inverted position. The adaptor has an elongated tubular body. While relatively basic, the adaptor dramatically...
Published: 4/8/2024   |   Inventor(s): Margaret Beddall, Pratip Chattopadhyay, Mario Roederer
Keywords(s): AC3XXX, AC4XXX, AC6XXX, ADAPTER, AFXXXX, Cells, Cryopreservation, Cryopreserved, Cryo-sample, FROZEN, Listed LPM Shmilovich as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Thawing, WIXXXX, WMXXXX, XDXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Consumer Products, Application > Non-Medical Devices, Application > Medical Devices, Application > Research Materials
Engineering Neural Stem Cells Using Homologous Recombination
Methods for modifying the genome of a Neural Stem Cell (NSC) are disclosed. Also, methods for differentiating NSCs into neurons and glia are described. NSCs are multipotent, self-renewing cells found in the central nervous system, capable of differentiating into neurons and glia. NSCs can be generated efficiently from pluripotent stem cells (PSCs)...
Published: 12/27/2024   |   Inventor(s): Mahendra Rao, Jizhong Zou, Raymond Funahashi, Nasir Malik
Keywords(s): Cells, EFFECTOR, Gene, Listed LPM Vepa as of 4/15/2015, NB1XXX, Nucleases, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SOMATIC, TAl, Targeting, VEXXXX, WIXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX
Category(s): Application > Research Materials, Application > Therapeutics, TherapeuticArea > Neurology
1 2 3 4