Search Results - therapeutic

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Well-Characterized Non-Genetically Modified Bovine Muscle Cell Lines for Research Use
Well-Characterized Non-Genetically Modified Bovine Muscle Cell Lines for Research Use Executive Summary: Well-characterized non-genetically modified bovine primary muscle cell lines have been sorted based on genetic information and proliferate well for research use. Background: Animal cell lines are utilized for a variety of medical and veterinary...
Published: 5/6/2024   |   Inventor(s): Jongkyoo Kim
Keywords(s):  
Category(s): Agricultural, Agriculture, Animal/Veterinary, Biotechnology, Veterinary, Therapeutic
Novel treatment for CTNNB1 syndrome
SUMMARY Tufts University investigator, Michelle Jacob, and Broad Institute’s Florence Wagner, have shown significant improvements in symptoms of CTNNB1 neurodevelopmental disorder in a heterozygous mouse model using a novel small molecule targeting β-catenin signaling. BACKGROUND The CTNNB1 mutation is an extremely rare genetic neurodevelopmental...
Published: 4/29/2024   |   Inventor(s): Michele Jacob, Jonathan Alexander, Florence Wagner
Keywords(s):  
Category(s): Therapeutic, Therapeutic: small molecule
AdipoAI: An Adiponectin Receptor Agonist for Treatment of Inflammation and Diabetes
BACKGROUND Adiponectin (APN) is an endogenous protein hormone which binds to Adiponectin Receptors 1 and 2 to exert an anti-inflammatory response and regulate glucose and fatty acid metabolism. Low APN levels in serum are associated with an increased risk of metabolic diseases and inflammatory disorders such as Type 2 Diabetes (T2D), heart disease,...
Published: 4/29/2024   |   Inventor(s): Jinkun (Jake) Chen, Qisheng Tu, Xingwen Wu
Keywords(s):  
Category(s): Therapeutic, Therapeutic: anti-inflammatory, Therapeutic: small molecule
RNA-Targeted Small Molecules as Potential Antiviral Therapy (HIV, SARS etc)
Brief Description: A high error rate of HIV -I reverse transcriptase coupled with a fast replication cycle associated with HIV -1 favors rapid development and selection of drug resistant strains. Therefore, identification of small molecules capable of inhibiting viral components necessary for HIV -1 proliferation continues to be of great importance....
Published: 10/28/2024   |   Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Joseph Wedekind
Keywords(s): AIDS, HIV, Small Molecule, Therapy
Category(s): Therapeutic
Protease Activated Cytokines as Anti-Cancer Therapy
A novel therapy method for delivering localized anti-cancer responses without adverse body-wide side effects. Problem Solved by the Technology Despite remarkable success at identifying tumor-associated antigens (TAA), generating effective anti-tumor immune response has not been successful at eliminating tumors. Systemically administered active drugs...
Published: 10/28/2024   |   Inventor(s): John Frelinger, John Puskas, Baek Kim, Mark Sullivan
Keywords(s): Cancer, Immunotherapy, Oncology, Therapy
Category(s): Therapeutic
Human Monoclonal Antibodies for Prevention and Treatment of Influenza Virus Infections
Background Seasonal influenza, also referred to as influenza or flu, is a contagious respiratory viral illness. Influenza infection varies in severity, causing asymptomatic infection to fatal disease, particularly for high-risk patient populations such as the elderly (over 65 years of age), young children (under five years of age), pregnant women,...
Published: 10/28/2024   |   Inventor(s): James Kobie, Luis Martinez-Sobrido, Michael Piepenbrink, Aitor Nogales-Gonzalez
Keywords(s):  
Category(s): Therapeutic
Human Monoclonal Antibodies for Prevention and Treatment of Influenza Virus Infections
Background Seasonal influenza, also referred to as influenza or flu, is a contagious respiratory viral illness. Influenza infection varies in severity, causing asymptomatic infection to fatal disease, particularly for high-risk patient populations such as the elderly (over 65 years of age), young children (under five years of age), pregnant women,...
Published: 10/28/2024   |   Inventor(s): James Kobie, Luis Martinez-Sobrido, Aitor Nogales-Gonzalez, Michael Piepenbrink
Keywords(s):  
Category(s): Therapeutic
Treatment of caries using probiotics
Background Dental caries, also known as tooth decay or cavity is one of the world's most common oral health problems today. According to the World Health Organization (WHO), 60%-90% of school-aged children and nearly 100% of adults worldwide have dental cavities. They can affect people in a variety of ways, including infections, tooth pain, stunting...
Published: 10/28/2024   |   Inventor(s): Jin Xiao
Keywords(s):  
Category(s): Therapeutic
New GsMTx4D- conjugates for joint-injury-induced osteoarthritis treatment
­Background Arthritis presently impacts more than fifty million adults, plaguing one in five Americans with the number one cause of disability in the U.S. Examples of current treatments against arthritis include intra-articular injections of hyaluronic acid or corticosteroids, but these treatments are limited to providing short term pain relief...
Published: 5/7/2024   |   Inventor(s): Whasil Lee, Thomas Suchyna
Keywords(s):  
Category(s): Therapeutic
Recombinant Fungal Peroxidase
­An economical method of producing recombinant Arthromyces ramosus peroxidase with high yield, purity, stability and robustness Background Peroxidases are valuable heme-containing enzymes that catalyze the oxidation of various phenolic and non-phenolic substrates by hydrogen peroxide. They have important applications in biomedicine, agriculture,...
Published: 3/16/2023   |   Inventor(s): Qing Xiao Li, Yuqun Yao
Keywords(s):  
Category(s): Agriculture/Aquaculture, Environmental Sciences, Therapeutic
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