Search Results - vaccines

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Raman Spectroscopy for Probing Encapsulation of mRNA in Lipid Nanoparticles

This technology uses deep ultraviolet Raman spectroscopy and advanced data analysis to quickly and non-destructively measure how much mRNA is unencapsulated in lipid nanoparticles, improving quality control for mRNA vaccines and therapeutics without chemical labels. Background: Messenger RNA (mRNA) therapeutics, particularly those delivered via lipid...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Igor Lednev, Alexander Shekhtman, Sergei Reverdatto, Sila Jin, Young Mee Jung

Keywords(s): mRNA, Raman spectroscopy, spectroscopy, statistical analysis, Technologies, therapeutics, vaccines

Category(s): Campus > University at Albany, Technology Classifications > Gene Therapy

Enhancement of adaptive immune responses by post-inoculation administration of fenretinide (N-(4-hydroxyphenyl)retinamide)

This technology uses fenretinide, a synthetic vitamin A derivative, to boost the body’s adaptive immune response after vaccination or infection, making vaccines more effective, especially for poorly immunogenic agents or immunocompromised individuals, without increasing infection severity. Background: The field of vaccine development and immunotherapy...

Published: 6/1/2026 | Updated: 5/29/2026 | Inventor(s): Adam Waickman, Stephen Thomas, David Foster, Herbert Slade

Keywords(s): Technologies, vaccine stability, vaccines

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Anti C. difficile Recurrence Vaccine Targeting Spore Colonization

Advantages Targets spore colonization, the root cause of CDI recurrence Broad coverage across diverse C. difficile strains Demonstrated protection in mice (reduced disease severity, toxins, and spore burden) Flexible delivery as injectable protein or oral L. lactis, enabling systemic + gut‑level immunity Summary Clostridioides difficile remains...

Published: 5/11/2026 | Updated: 2/17/2026 | Inventor(s): Xingmin Sun, Lubem Agbendeh, Soumyadeep Chakraborty

Keywords(s): Infectious Diseases, Vaccines

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics

Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs

A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics. Background: The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...

Published: 1/29/2026 | Updated: 10/24/2025 | Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto

Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines

Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines

FLR: A Triple-Target Fusion Vaccine Candidate Against Clostridioides difficile

Advantages Multi-Antigen Targeting for Broad Protection: targets three distinct virulence factors (FliC, LP2, RBD2) simultaneously Targeting Hypervirulent Strain Pathogenesis Significant protection from infection and weight loss Reduced fecal toxin and spore levels Summary Clostridioides difficile (C. difficile) is a bacterium that colonizes...

Published: 5/13/2026 | Updated: 8/4/2025 | Inventor(s): Xingmin Sun

Keywords(s): Infectious Diseases Treatment, Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering

Novel Malaria Vaccine Candidates: CSP- Nanoparticle Vaccine Candidates for Plasmodium vivax

Advantages Enhanced Immunogenicity: Nanoparticles (NPs) boost immune responses compared to conventional subunit vaccines Broad Protection: Focusing on conserved regions of CSP, the vaccine elicits cross-reactive antibodies that may protect against multiple P. vivax strains Functional Efficacy: Generated antibodies inhibit sporozoite invasion of...

Published: 5/11/2026 | Updated: 6/5/2025 | Inventor(s): Francis Ntumngia, John Adams

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals

Zika Virus Vaccine

A killed ZIKA vaccine that prevents infection and is safe for pregnant women. Background: Zika virus (ZIKV) is a Flavivirus transmitted by mosquitoes. First discovered in 1947, it remained a minor infectious entity until 2007, when the first large outbreak was reported in Micronesia. Subsequent severe outbreaks in French Polynesia (2013-14)...

Published: 1/30/2026 | Updated: 5/13/2025 | Inventor(s): Timothy Endy, Kenneth Eckels

Keywords(s): Technologies, vaccines

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Cwp2: A Novel Anti‑Colonization Vaccine Candidate for Preventing Clostridioides difficile Infection

Advantages: Blocks bacterial colonization, not just toxin activity Induces strong IgG and IgA antibody response in animal models. Significant protection in vivo, reducing mortality, diarrhea, toxins, and spore burden Summary: Clostridioides difficile infection (CDI) is a leading cause of antibiotic‑associated diarrhea and colitis, with...

Published: 5/11/2026 | Updated: 9/17/2024 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

Kaposi Sarcoma Associated Herpesvirus Vaccine Development (UCLA Case Nos. 2023-038, 2025-045, 2025-9A2)

UCLA researchers in the Department of Molecular and Medical Pharmacology have a novel discovery showing the potential benefit of engaging complement-mediated antibody functions in future KSHV vaccine development. BACKGROUND: Kaposi Sarcoma Associated Herpesvirus (KHSV) is the etiological agent for cancers such as Kaposi Sarcoma (KS) and primary effusion...

Published: 10/1/2025 | Updated: 4/16/2024 | Inventor(s): Ting-Ting Wu

Keywords(s): herpes, herpesvirus, kaposi sarcoma, Vaccines

Category(s): Therapeutics > Vaccines

Summary: UCLA researchers have developed a software to accelerate vaccine clinical trial processes by modeling disease behavior and targeting future trial participants. Background: Vaccine clinical trials are time-intensive processes; ones that may be necessary during active pandemics in which time is of short supply. One of the primary factors contributing...

Published: 2/14/2025 | Updated: 4/9/2024 | Inventor(s): Akihiro Nishi

Keywords(s): Bioinformatics, Clinical Trial, Live attenuated vaccine, Public Health, Simulation & Modeling, Software & Algorithms, Therapeutics & Vaccines, Vaccines

Category(s): Software & Algorithms > Statistical Models, Software & Algorithms > Bioinformatics

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