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A Vaccine Technology for Preventing Clostridioides difficile Infection Using Cell Wall Protein 2 (CWP 2)

Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....

Published: 9/17/2024 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

Kaposi Sarcoma Associated Herpesvirus Vaccine Development (UCLA Case No. 2023-038)

UCLA researchers in the Department of Molecular and Medical Pharmacology have a novel discovery showing the potential benefit of engaging complement-mediated antibody functions in future KSHV vaccine development. BACKGROUND: Kaposi Sarcoma Associated Herpesvirus (KHSV) is the etiological agent for cancers such as Kaposi Sarcoma (KS) and primary...

Published: 4/16/2024 | Inventor(s): Ting-Ting Wu

Keywords(s): herpes, herpesvirus, kaposi sarcoma, Vaccines

Category(s): Therapeutics > Vaccines

Summary: UCLA researchers have developed a software to accelerate vaccine clinical trial processes by modeling disease behavior and targeting future trial participants. Background: Vaccine clinical trials are time-intensive processes; ones that may be necessary during active pandemics in which time is of short supply. One of the primary factors contributing...

Published: 9/18/2024 | Inventor(s): Akihiro Nishi

Keywords(s): Bioinformatics, Clinical Trial, Live attenuated vaccine, Public Health, Simulation & Modeling, Software & Algorithms, Therapeutics & Vaccines, Vaccines

Category(s): Software & Algorithms > Statistical Models, Software & Algorithms > Bioinformatics

Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/26/2024 | Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

Novel Safe Potent Single Vector Platform Vaccines Against Melioidosis (UCLA Case No. 2023-119)

UCLA researchers in the School of Medicine have developed a novel single-vector platform vaccine for preventing melioidosis, an infection caused by Burkholderia pseudomallei. BACKGROUND: Melioidosis, also known as Whitmore’s disease, is an infectious disease that can infect both humans and animals. The bacterium Burkholderia pseudomallei (Bp)...

Published: 2/21/2024 | Inventor(s): Marcus Horwitz

Keywords(s): Burkholderia pseudomallei, Intracellular Pathogens, Live attenuated vaccine, Melioidosis, Pathogen, Select Agents, Tier 1 Diseases, Vaccines

Category(s): Therapeutics > Infectious Diseases

Receptor Binding Domain 2 of CDTb Component of the Clostridioides Difficile Binary Toxin CDT as a Vaccine Component Against C. Difficile Infection

Advantages: Enhanced Vaccine Conservation: This technology ensures the conservation of critical vaccine components across diverse C. difficile strains, improving vaccine effectiveness. Immunogenic Potential: RBD2, a key discovery, exhibits exceptional immunogenicity, promising robust immune responses in vaccine recipients. Inhibition of CDT...

Published: 9/3/2024 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Infectious Diseases, Vaccines

Category(s): Technology Classifications > Medical > Infectious Diseases

Recombinant Fusion Protein Containing Clostridioides Difficile Flagellin Proteins FliC and FliD as a Vaccine Candidate Against C. Difficile Infection

Advantages: Novel Vaccine Approach: Vacine targeting C. difficile flagellar proteins FliC and FliD. Enhanced Protection: FliCD provides robust immunity, reduces C. difficile infection severity, and decreases spore and toxin levels in feces. Potential Alternative Therapy: Anti-FliCD serum demonstrates promise as an adjunct therapy for CDI,...

Published: 2/13/2024 | Inventor(s): Xingmin Sun

Keywords(s): Infectious Diseases, Vaccines

Category(s): Technology Classifications > Medical > Infectious Diseases

A Dendritic Cell Vaccine to Immunize Cancer Patients Against Mutated Neoantigens Expressed by the Autologous Cancer

Abstract: Vaccines against non-viral cancers target mainly differentiation antigens, cancer testis antigens, and overexpressed antigens. One common feature to these antigens is their presence in central immunological tolerance. Using these vaccines, T cells underwent depletion of high avidity clones directed against such antigens. This depletion can...

Published: 4/8/2024 | Inventor(s): Gal Cafri, Paul Robbins, Jared Gartner, Steven Rosenberg

Keywords(s): CANCER, Dendritic cells, Immunotherapy, Neoantigens, Rosenberg, T Cells, vaccines

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Vaccines

Zika Virus Vaccine

A killed ZIKA vaccine that prevents infection and is safe for pregnant women. Background: Zika virus (ZIKV) is a Flavivirus transmitted by mosquitoes. First discovered in 1947, it remained a minor infectious entity until 2007, when the first large outbreak was reported in Micronesia. Subsequent severe outbreaks in French Polynesia (2013-14)...

Published: 9/24/2024 | Inventor(s): Timothy Endy

Keywords(s): Technologies, vaccines

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Novel Inactivated Zika Vaccine Candidate Based on Purified Wild-type Zika Virus — for Zika Vaccine and Diagnostic Assay Development

Zika virus (ZIKV) spreads to people primarily through bite by infected Aedes mosquitoes. ZIKV infection during pregnancy can cause stillbirths or affect the fetus by causing serious birth defects, such as microcephaly and other brain defects. Although uncommon, adults with ZIKV can also develop Guillain-Barre syndrome and other neurological disorders....

Published: 4/8/2024 | Inventor(s): Holli Giebler, Windy Baldwin, Claire Kinney, Jill Livengood

Keywords(s): Compositions, Immunogenic, Methods, SAME, vaccines, YBXXXX, YCXXXX, YDXXXX, YXXXXX, Zika

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