Search Results - vaccines

37 Results

Sort By:

FLR: A Triple-Target Fusion Vaccine Candidate Against Clostridioides difficile

Advantages Multi-Antigen Targeting for Broad Protection: targets three distinct virulence factors (FliC, LP2, RBD2) simultaneously Targeting Hypervirulent Strain Pathogenesis Significant protection from infection and weight loss Reduced fecal toxin and spore levels Summary Clostridioides difficile (C. difficile) is a bacterium that colonizes...

Published: 8/7/2025 | Inventor(s): Xingmin Sun

Keywords(s): Infectious Diseases Treatment, Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering

Novel Malaria Vaccine Candidates: CSP- Nanoparticle Vaccine Candidates for Plasmodium vivax

Advantages Enhanced Immunogenicity: Nanoparticles (NPs) boost immune responses compared to conventional subunit vaccines Broad Protection: Focusing on conserved regions of CSP, the vaccine elicits cross-reactive antibodies that may protect against multiple P. vivax strains Functional Efficacy: Generated antibodies inhibit sporozoite invasion of...

Published: 6/6/2025 | Inventor(s): Francis Ntumngia, John Adams

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals

Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs

A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics. Background: The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...

Published: 8/21/2025 | Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto

Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines

Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines

Zika Virus Vaccine

A killed ZIKA vaccine that prevents infection and is safe for pregnant women. Background: Zika virus (ZIKV) is a Flavivirus transmitted by mosquitoes. First discovered in 1947, it remained a minor infectious entity until 2007, when the first large outbreak was reported in Micronesia. Subsequent severe outbreaks in French Polynesia (2013-14)...

Published: 5/13/2025 | Inventor(s): Timothy Endy, Kenneth Eckels

Keywords(s): Technologies, vaccines

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Combination Cancer Therapy Methods and Agents (UCLA Case No. 2024-084)

UCLA researchers from the Department of Medicine, Pathology, & Laboratory Medicine and Molecular & Medical Pharmacology have identified a novel cell-based therapy that leads to enhanced immunotherapy efficacy and overcomes treatment resistance to immune checkpoint blockade in non-small cell lung cancer. BACKGROUND: Non-small cell lung cancer...

Published: 7/17/2025 | Inventor(s): Bin Liu, Steven Dubinett

Keywords(s): anti-tumor immunity, cell-based therapy, Immune checkpoint blockade, Immunotherapy, non-small cell lung cancer, treatment resistance, Tumor microenvironment, Vaccines

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Respiratory And Pulmonary

Vaccine Candidate for Preventing Clostridioides difficile Infection: Cell Wall Protein 2 (CWP 2)

Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....

Published: 1/31/2025 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

Kaposi Sarcoma Associated Herpesvirus Vaccine Development (UCLA Case No. 2023-038)

UCLA researchers in the Department of Molecular and Medical Pharmacology have a novel discovery showing the potential benefit of engaging complement-mediated antibody functions in future KSHV vaccine development. BACKGROUND: Kaposi Sarcoma Associated Herpesvirus (KHSV) is the etiological agent for cancers such as Kaposi Sarcoma (KS) and primary...

Published: 2/14/2025 | Inventor(s): Ting-Ting Wu

Keywords(s): herpes, herpesvirus, kaposi sarcoma, Vaccines

Category(s): Therapeutics > Vaccines

Summary: UCLA researchers have developed a software to accelerate vaccine clinical trial processes by modeling disease behavior and targeting future trial participants. Background: Vaccine clinical trials are time-intensive processes; ones that may be necessary during active pandemics in which time is of short supply. One of the primary factors contributing...

Published: 2/14/2025 | Inventor(s): Akihiro Nishi

Keywords(s): Bioinformatics, Clinical Trial, Live attenuated vaccine, Public Health, Simulation & Modeling, Software & Algorithms, Therapeutics & Vaccines, Vaccines

Category(s): Software & Algorithms > Statistical Models, Software & Algorithms > Bioinformatics

Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 7/17/2025 | Inventor(s): Mohammad Mahdi Hasani Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

Novel Safe Potent Single Vector Platform Vaccines Against Melioidosis (UCLA Case No. 2023-119)

UCLA researchers in the School of Medicine have developed a novel single-vector platform vaccine for preventing melioidosis, an infection caused by Burkholderia pseudomallei. BACKGROUND: Melioidosis, also known as Whitmore’s disease, is an infectious disease that can infect both humans and animals. The bacterium Burkholderia pseudomallei (Bp)...

Published: 7/17/2025 | Inventor(s): Marcus Horwitz

Keywords(s): Burkholderia pseudomallei, Intracellular Pathogens, Live attenuated vaccine, Melioidosis, Pathogen, Select Agents, Tier 1 Diseases, Vaccines

Category(s): Therapeutics > Infectious Diseases

1 2 3 4