Search Results - kidney

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Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range
Abstract: Small molecule fluorescent probes are important tools in diagnostic medicine. Existing far-red and near-IR cyanine fluorophores (e.g. Cy5, Alexa 647, Cy7, ICG) are active in the far-red and near-range, but these agents suffer from modest quantum yields (brightness) which limit wide utility. It has been reported that the limited brightness...
Published: 4/8/2024   |   Inventor(s): Martin Schnermann, Megan Michie
Keywords(s): CANCER, Cardiovascular, cyanine fluorophores, FACS, Fluorescence guided surgery, Fluorescent probes, gastrointestinal (GI), IMAGING, KIDNEY, Schnermann, super resolution microscopy
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Gastroenterology, TherapeuticArea > Nephrology
A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies
Abstract: The ability to hold and transport tissue, especially needle biopsies in a pre-defined and controlled environment is critical for the preservation of biopsy samples in downstream analytic applications. Currently, tissue specimens are placed in open containers with variable, poorly controlled solutions applied to them, often in less than sterile...
Published: 4/8/2024   |   Inventor(s): Stephen Hewitt, Robert Star, Hiroshi Kijoma, Jeffrey Hanson, Armando Filie, Russell Bandle
Keywords(s): COLLECTION, DEVICE, FIXATION, Hewitt, KIDNEY, liver, LUNG, Needle Biopsy, PANCREAS, PRESERVATION, STERILE, Storage, Tissue, Transportation
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Medical Devices, Collaboration Sought > Collaboration, Application > Non-Medical Devices
Treatment of Chronic Kidney Disease with Synthetic Amphipathic Peptides
The invention is directed to treatment of chronic kidney disease by administering a synthetic, amphipathic helical peptide known as 5A-37pA, and novel derivatives thereof. Scientists at NIDDK have demonstrated that invention peptides antagonize activity of a particular scavenger receptor known as CD36. Using an in vivo model, NIDDK scientists have shown...
Published: 7/25/2024   |   Inventor(s): Peter Yuen, Robert Star, Alexander Bocharov, Alan Remaley, Thomas Eggerman, Ana Souza
Keywords(s): 5A-37pA, AMPHIPATHIC, Chronic, Disease, HELICAL, KIDNEY, Peptide, treatment, VDXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VPXXXX, WIXXXX, WJXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials
Aquaporin 2 Polyclonal Antibodies
Aquaporins, also known as water channels, form pores in cell membranes and selectively transport water in and out of the cell. Aquaporins are involved in regulation of water balance and blood pressure, and thirteen different isoforms have been found in mammals. Aquaporin 2 (AQP2) is located in the collecting duct of the kidney, and is regulated by...
Published: 7/25/2024   |   Inventor(s): Mark Knepper
Keywords(s): Anti-Aquaporin, antibodies, ANTIBODY, AQUAPORIN, DIABETES, diabetes insipidus, IDXXXX, IXXXXX, KIDNEY, Nephrogenic diabetes insipidus, polyclonal, polyclonal antibodies, UAXXXX, WATER, water channel
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
2021-360 PERSONALIZED CONTROL OF HEMODYNAMICS (PCH) IN HIGH-RISK SURGERY PATIENTS
SUMMARY: UCLA researchers have developed a personalized and automated control system of a patient’s hemodynamics during surgery. BACKGROUND: Hemodynamics is the study of blood flow, measuring a variety of inter-connected metrics including oxygenation, cardiac efficiency and output. It provides critical metrics that informs and enables physicians...
Published: 12/15/2023   |   Inventor(s): Chih-Ming Ho, Soban Umar, Jure Marijic, Daniel Garcia, Jinyoung Brian Jeong, Michael Zargari
Keywords(s): Anesthesiology, Artery, Blood Pressure, Hemodynamics, Instrumentation, Kidney, Sensors, Surgery, Surgical Instrument, Surgical Tools
Category(s): Medical Devices, Medical Devices > Surgical Tools
2020-859-1 Novel Approach to Modulate Renal Neurotransmission via Percutaneous
SUMMARY: UCLA researchers in the Department of Medicine-Cardiology have developed a method that applies renal denervation to specific renal arteries to treat resistant hypertension. BACKGROUND: Sympathetic nervous system activation occurs when chemicals, such as adrenaline, bind to multiple receptors that are responsible for vital functions such...
Published: 8/2/2023   |   Inventor(s): Olujimi Ajijola
Keywords(s): Artery, Blood Pressure, Hypertension, Hypertension Urine, Kidney, Medical Device, Renal, Surgery
Category(s): Life Science Research Tools, Diagnostic Markers, Medical Devices
In Vitro Mesangial Cell Model for Progression of Glomerulosclerosis
Cell Line Useful for Testing New DrugsAn in vitro kidney mesangial cell model has been produced for the investigation of mechanisms by which glomerulosclerosis develops in non-diabetic kidney disease. Researchers have characterized the mesangial cells as high producers of extracellular matrix proteins by isolating glomerular mesangial cells from a mutant...
Published: 7/12/2022   |   Inventor(s): Charles Heilig, Kathleen Heilig
Keywords(s): Cells, extracellular matrix protein, Fvb Os, glomerulosclerosis, Glucose Transport, glut1, kidney, Mesangial cell, Mouse, Mutant mouse, Oligosyndactyly, Progression of renal disease
Category(s): Technology Classifications > Research Tools > Cell Lines