Search Results - drug+discovery

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Zika DNA Vaccine
Technology Overview: A plasmid DNA vaccine thatencodes a secreted form of non-structural protein 1(secNS1). It is highly immunogenic and offers completesystemic protection from Zika in vaccinated mice. Thevaccine protects and completely eliminates ZIKA virus inpreclinical studies. We have modified the plasmid DNAvaccine to include a leader sequence...
Published: 10/7/2021   |   Inventor(s):  
Keywords(s):  
Category(s): Medical, Diagnostic, Biology, Therapeutic, Drug Discovery, Biotechnology
Cellular Vaccine and Method of Inducing an Immune Response in a Subject (formerly referred to as Suicide Gene NSP4 as an Augment for DNA Vaccines)
Technology OverviewOur cytolytic DNA vaccines encode a viral immunogen and a cytolytic protein to induce necrosis in targeted cells resulting in release of a range of damage associated molecular patterns (DAMPs) and cross presentation of the immunogen. This results in increased virus-specific immune responses. The goal is to attract circulating dendritic...
Published: 12/1/2021   |   Inventor(s):  
Keywords(s):  
Category(s): Medical, Drug Discovery
Clinical Trial Capability
Researchers who perform both clinical work and research in their specific fields of expertise are highly sort after by industry to study the latest therapies. They provide customers with credible, reliable and unbiased results which are highly regarded by regulators.The University of Adelaide's areas of expertise include:- Pain and Anaesthesia- Cardiology-...
Published: 9/7/2017   |   Inventor(s):  
Keywords(s): Addiction / Drug Dependency, Analytical Services, Anti-infectives, Assays, AutoImmune, Biology, Biomaterials, Biopharmaceuticals, Biosensing, Cancer, Cardiovascular Disease, CNS, Contraception, Diabetes, Drug Delivery, Drug Development, Endocrinology, Gastroenterology, Gastrointestinal, Gene/Cell Therapy, Genetic Disorders, Haematology, Hormone Therapy, Immunology, Infectious Disease, Inflammation, Medical Device, Mental Health, Metabolic Disease, Musculoskelatal, Neurology, Oncology, Ophthalmic, Osteo / Bone, Pathology, Pharmacogenetics, Pulmonary, Regenerative Medicine, Renal, Reproductive, Respiritory, Skin/Dermatological, Systems Biology, Urological, Vaccines
Category(s): Medical, Biomedical, Biotechnology, Dental, Devices, Diagnostic, Drug Delivery, Drug Discovery, Drug Screening, Gene Therapy, Genomics/Genetics, Nanotechnology, Therapeutic
Drug Eluting Stent for High Risk Patients
Reference Number:0204 Background Stent implantation is a highly effective treatment for restoring blood flow through an atherosclerotic artery; however restenosis (a re-narrowing of the diseased artery) occurs in a significant proportion of patients. Drug-eluting stents have been developed to limit restenosis and although they represent a major...
Published: 2/1/2011   |   Inventor(s): Roger Wadsworth, Cherry Wainwright, Nigel Pyne, Susan Pyne, Lorraine Work
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Category(s): Drug Discovery
Novel Compound for the Treatment of Psoriasis
Reference Number:0182 Background Psoriasis is a skin disease characterised by inflammation and scaly lesions of the skin affecting 2-3% of the population in Europe and North America. Several different therapies are currently being used to treat psoriasis, but they all have the possibility of serious side effects. Additionally, they are expensive...
Published: 2/1/2011   |   Inventor(s): William Stimson, Alexander Gray, Chaman Anand, Peter Waterman, Solomon Habtemariam
Keywords(s):  
Category(s): Drug Discovery
A Novel Anti-Inflammatory Agent
Reference Number:1647 Background Chronic inflammation contributes to a broad spectrum of diseases including arthritis, psoriasis, diabetes, allergy, connective tissue diseases, and heart disease. Despite the range of current therapeutics on offer, there is unmet clinical need as treatments such as corticosteroids, though often effective, are associated...
Published: 2/21/2014   |   Inventor(s): William Harnett, Margaret Harnett, Colin Suckling, Iain Mcinnes, Judith Huggan
Keywords(s):  
Category(s): Drug Discovery
Selectively enhancing nitric oxide activity in damaged blood vessels
Reference Number: 1591 Background Many drugs are aimed at enhancing the therapeutic potential of nitric oxide (NO) in the cardiovascular system. These generally lack selectivity, hence there is a need to treat diseased tissues more specifically in order to restore their function. This can be achieved by boosting the natural enzymatic synthesis of...
Published: 2/21/2014   |   Inventor(s): Roger Wadsworth, Colin Suckling, Colin Gibson
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Category(s): Drug Discovery
Drug Discovery Portal
Reference Number: 1755 The Drug Discovery Portal (DDP) is based on a unique assembly of highly diverse compounds that are not otherwise commercially available. The compounds are initially used in silico for virtual screening, but they are linked to the originating chemists so that samples are available for physical screening and analogues can be...
Published: 2/20/2024   |   Inventor(s): Simon Mackay
Keywords(s):  
Category(s): Drug Discovery
Method for the Identification of Allosteric Drug Binding Sites
Reference Number: 1695 Background Conventional methods for protein-targeted drug design are very heavily biased towards exploiting those sites on the protein targets where other molecules are already known to bind. In the case of enzymes, this usually means seeking ligands that are capable of binding tightly to the catalytic sites in place of the...
Published: 8/29/2024   |   Inventor(s): Mark Dufton, John Wilson, Leighton Pritchard, Christopher Foley, Evelin Kozma, Linda Milne
Keywords(s):  
Category(s): Drug Discovery