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Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents
Homocystinuria (HCU), a group of inherited disorders, causes symptoms ranging from failure to thrive and developmental delays in infants or young children to abnormal blood clots with onset in adults.1 Approximately 1 in 200,000 to 335,000 people have HCU globally.2 Various clinical settings use the dried blood spot (DBS) for sample collection methods...
Published: 10/28/2024   |   Inventor(s): Charles Pickens, Konstantinos Petritis
Keywords(s): 4AXXXX, Agents, ASSAYS, Derivatization, Hcy, HOMOCYSTEINE, Maleimides, Multiplexing, Newborn, Primary, screening, SELECTIVE, VDXXXX, VPXXXX, WFXXXX, WHXXXX, WIXXXX, XCXXXX, XHXXXX, YAXXXX, YDXXXX, YFXXXX
Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Dental, Application > Research Materials, ResearchProducts > Research Equipment, Application > Occupational Safety and Health, Application > Diagnostics
Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation
During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host defense against inhaled pathogens, excessive accumulation of PMNs in the lung contributes to the pathogenesis of several prevalent lung disorders, including...
Published: 10/28/2024   |   Inventor(s): Carmen Williams, Wan-Chi Lin, Michael Fessler
Keywords(s): 2, BARRIER, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DBXXXX, During, DXXXXX, Epithelial, Infection, Inflammation, INTEGRITY, LUNG, MEMBRANE, PROTECT, Protein, respiratory, Targeting, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WBXXXX, WJXXXX, WKXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, ResearchProducts > Antibodies, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology
High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a massive scale. NIEHS researchers developed a massively paralleled multiplexed screening method using next generation sequencing (NGS). This method uses...
Published: 10/28/2024   |   Inventor(s): Brian Papa, Oswaldo Lozoya
Keywords(s): Acid, assay, DA4BXX, Diagnosis, HOST, Infection, Massively, Multi-patient, Nucleic, Paralleled, PATHOGENIC, PHYSIOLOGY, sequencing, Surveillance, VLXXXX, WBXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics
A Novel Reagent for Labeling PET Tracers at Trifluoromethyl Groups
The molecular imaging technique of positron emission tomography (PET) is an increasingly important tool in biomedical research and in drug discovery and development. Many small molecule drugs and potential PET radiotracers carry trifluoromethyl (CF3) groups. Because CF3 groups are generally considered to be metabolically stable, there is a strong interest...
Published: 10/28/2024   |   Inventor(s): Mohammad Haskali, Victor Pike
Keywords(s): :, [11C]Fluoroalkanes, Added, AGENT, LABELING, Method, No-Carrier, PET, Producing, Radiotracers, VAXXXX, VCXXXX, VDXXXX, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Geriatrics, Application > Software / Apps, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Neurology, Application > Medical Devices, TherapeuticArea > Immunology
Potential New Drugs for Treating or Preventing Pruritus
NIH scientists have identified new compositions that could potentially be used to treat or prevent pruritus (itchiness). The newly discovered compounds can block a newly identified itch pathway and might be effective for persistent itch caused by psoriasis, atopic dermatitis, renal failure, liver cirrhosis and chemotherapy. These compounds are different...
Published: 10/28/2024   |   Inventor(s): Hans Solinski, James Inglese, Patricia Dranchak, Mark Hoon
Keywords(s): BLOCKAGE, IB6XXX, Itch, Listed LPM Vepa as of 4/15/2015, Nppb, Npr1, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, Sensation, TRANSMITTER, treatment, VOXXXX, VPXXXX, WKXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): TherapeuticArea > Reproductive Health, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, TherapeuticArea > Ophthalmology, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Cardiology
Novel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain Metabolites
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence type being applied. This invention describes a novel MRS technique that involves preparing longitudinal steady states at different flip angles using trains...
Published: 10/28/2024   |   Inventor(s): Jun Shen, Linqing Li
Keywords(s): AAXXXX, DRIVEN, IMAGING, ImagingMRI, LINEAR, METABOLITE, MRI, NCXXXX, Probing, QUANTIFICATION, Relaxation, RF, States, Steady, VCXXXX, VEXXXX, Vivo, VNXXXX, WBXXXX, XFXXXX, YAXXXX, YDXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Psychiatry/Mental Health, Application > Non-Medical Devices, TherapeuticArea > Oncology, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, Application > Research Materials
Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population
Rotaviral infection is the most common gastrointestinal illness of children in the world, affecting both developed and developing economies. There is no specific drug treatment for rotavirus infection. Vaccination and good hygiene are key to prevention. Approximately 5-10% of the world's population are Lewis histoblood group antigen negative, that percentage...
Published: 10/28/2024   |   Inventor(s): Yuhuan Wang, Baoming Jiang
Keywords(s): Candidate, CHARACTERIZATION, G9P[6], Human, Isolation, NCIRD, NCIRD-DVD, rotavirus, Strain, Vaccine, VLXXXX, WBXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WNXXXX, XKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health
Near Real-time, Low-cost, Hand-held Sensors for Measuring Elemental Concentration of Airborne Particles for Indoor or Outdoor Air Quality Monitoring
Airborne particles can have great impact on air quality, weather, and human health. In particular, long-term inhalation of toxic particulate matter in workplaces could pose a significant health risk. NIOSH scientists have developed a new, low-cost approach based on application of atmospheric radio frequency glow discharge (rf-GD) optical emission spectroscopy...
Published: 10/28/2024   |   Inventor(s): Lina Zheng, Pramod Kulkarni
Keywords(s): AEROSOLS, analysis, Atmospheric, DART, Discharge, Elemental, Emission, Glow, NIOSH-DART, SPECTROSCOPY, VBXXXX, VPXXXX, WAXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, XGXXXX, XIXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, Application > Vaccines, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Consumer Products
Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Development
Heartland virus (HRTV) is a novel tick-borne virus first discovered in 2009 that causes flu-like symptoms such as fever, headaches, fatigue, muscle aches, and diarrhea. Patients with HRTV often have low white blood cell counts, low platelet counts, and abnormal liver function tests which can become severe. Cases of Heartland virus disease have been...
Published: 10/28/2024   |   Inventor(s): Aaron Brault, Amanda Calvert
Keywords(s): antibodies, Diagnostics, heartland, Listed LPM Houze as of 4/15/2015, monoclonal, NCEZID, NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Specific, therapeutics, virus, WBXXXX, WFXXXX, WJXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products, Application > Diagnostics
Regenerative Therapy for Cartilage Damage
The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative...
Published: 8/21/2024   |   Inventor(s): Mitchell Shirvan, Rafael Gorodetsky, Sergei Kuznetsov, Astar Lazmi-Hailu, Pamela Robey
Keywords(s): Bone, Cartilage, Cells, Fibrin, Generation, Human, Hyaline, Marrow, Microbeads, STABLE, Stromal, TRANSPLANTATION, VAXXXX, Vivo, WJXXXX, XCXXXX, XDXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Application > Diagnostics, Application > Research Materials, Application > Non-Medical Devices, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Medical Devices
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