Search Results - biotechnology

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Demineralized Bone Paper and Applications Thereof
PRODUCT OPPORTUNITIES • Three-dimensional, living bone tissue grafts produced from stacked demineralized bone paper (DBP) for clinical applications • DBP-based high-throughput and high-content assay systems for bone disease drug discovery • Other DBP-containing products such as microfluidic bone marrow chips PRODUCT...
Published: 10/1/2025   |   Inventor(s): Jungwoo Lee, Jae-Hyuck Shim, Ryan Carpenter, Yongkuk Park, Jun-Goo Kwak
Keywords(s):  
Category(s): Biotechnology, Devices, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
An Ex Vivo Method of Generating Super Regulatory T Cells as a Cell-based Therapy for the Prevention of Graft-vs-Host Disease
PRODUCT OPPORTUNITIES • Cell-based therapy for the prevention of graft-versus-host disease ADVANTAGES • Simple, well-defined generation of personalized, cell-based therapy for the prevention of graft-versus-host disease • Generation of super regulatory T cells with greatly improved suppressive capacity. TECHNOLOGY...
Published: 9/25/2025   |   Inventor(s): Lisa Minter, Gregory Tew, Emrah Ozay
Keywords(s):  
Category(s): Biotechnology, Healthcare, Life Sciences, Research tools, Therapeutics & prevention
Novel Targets and Compounds to Treat Bladder Cancer
Alternative splicing modulating antisense oligonucleotides (ASOs) targeting novel identified alternative splicing changes associated with RBM10 mutations in bladder cancer. We are developing lead ASOs to treat bladder, and eventually other, cancers. Technology: Bladder cancer is the 9th most common malignant disease worldwide and 13 most frequent...
Published: 8/6/2025   |   Inventor(s): Juan Valcarcel, Ángel Guerra, Tobias Hoffmann
Keywords(s):  
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
A novel sampling method for the detection of oak wilt pathogen, Bretziella fagacearum in oak and chestnut
Executive Summary: A novel sampling method that uses petioles from fallen leaves is non-destructive and highly accurate for detecting Bretziella fagacearum, the fungus that causes oak wilt, using real-time PCR and culture-based methods. Background: Bretziella fagacearum has been distributed to much of the Midwest and Southern United States and...
Published: 7/7/2025   |   Inventor(s): Karandeep Chahal, Timothy Miles
Keywords(s):  
Category(s): Biotechnology, Environment, Agriculture
VITRUALGENOME, A VIRTUAL REALITY IMMERSIVE SYSTEM
VAlue proposition A virtual reality immersive system that enables users to visualize, explore, and analyze 3D genomes and their associated biochemical features. Combining VirtualGenome with Tensor-FLAMINGO and 3DVarientVision creates a technology that provides a high-resolution image of the altered 3D structure resulting from a genetic variant, decodes...
Published: 4/9/2025   |   Inventor(s): Jianrong Wang, Andre Popovitch, Hao Wang
Keywords(s):  
Category(s): Biotechnology, Computer Software, Education & Training
HIGH-RESOLUTION RECONSTRUCTION OF SINGLE-CELL 3D CHROMOSOMAL STRUCTURES
VAlue proposition The dynamic 3D spatial structure of chromosomes has variations across cells of different types and between cells of the same type. This structural variation between single cells plays an important role in regulating single-cell specific transcription and epigenetic landscapes. Computationally reconstructing chromosomal 3D structure...
Published: 4/9/2025   |   Inventor(s): Jianrong Wang, Jianliang Qian, Hao Wang
Keywords(s):  
Category(s): Biotechnology, Computer Software
3DVARIENTVISION: DECODE FUNCTIONAL IMPACTS OF GENETIC VARIANTS BASED ON 3D CHROMATIN
VAlue proposition Deciphering the effects and mechanisms of genetic variants is essential to understand human genetics and further precision medicine. A genetic variant is a permanent change in the nucleotide sequence that makes up a gene, also known as a gene mutation. Mutations can cause diseases or phenotypic changes. Typically, Genome Wide Association...
Published: 4/9/2025   |   Inventor(s): Jianrong Wang, Jiaxin Yang
Keywords(s):  
Category(s): Medical, Biotechnology, Computer Software
Light Scattering Fiber with Enhanced Side Emission for Photobioreactors
Executive Summary Photobioreactors are used to cultivate various photosynthetic microorganisms to produce useful materials such as biofuels, value added chemicals. These systems regulate key factors including light, temperature, carbon dioxide concentration, and nutrients. A key challenge with photobioreactors is getting enough light into the medium...
Published: 4/22/2025   |   Inventor(s): Xinyue Liu, Yijie Cheng
Keywords(s):  
Category(s): Environmental, Chemicals, Biotechnology, Photonics
The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses
Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...
Published: 9/6/2024   |   Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen
Keywords(s): Biomedical, Human Health, Pharma, Research, Veterinary Medicine
Category(s): Biotechnology, Biomedical, Pharma, Veterinary Medicine
Reagents, Devices, and Accessories for Kinetic Fluorogenic Chemical Quantification
Background Kinetic chromogenic (CG) and fluorogenic (FG) quantification deduces analyte concentration based on the reaction rate between the CG/FG probe and its targeted molecule. Little progress has been made in the past half century in either the theory or the applications of the kinetic spectroscopic quantification methods. Current kinetic CG/FG...
Published: 5/19/2025   |   Inventor(s): Dongmao Zhang, Max Wamsley
Keywords(s): Biomedical, Chemicals, Food, Instruments, Materials, Military or Defense, Research
Category(s): Biomedical, Materials, Instruments, Biotechnology, Agriculture & Food Science
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