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VITRUALGENOME, A VIRTUAL REALITY IMMERSIVE SYSTEM
VAlue proposition
A virtual reality immersive system that enables users to visualize, explore, and analyze 3D genomes and their associated biochemical features. Combining VirtualGenome with Tensor-FLAMINGO and 3DVarientVision creates a technology that provides a high-resolution image of the altered 3D structure resulting from a genetic variant, decodes...
Published: 4/9/2025
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Inventor(s): Jianrong Wang, Andre Popovitch, Hao Wang
Keywords(s):
Category(s): Biotechnology, Computer Software, Education & Training
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HIGH-RESOLUTION RECONSTRUCTION OF SINGLE-CELL 3D CHROMOSOMAL STRUCTURES
VAlue proposition
The dynamic 3D spatial structure of chromosomes has variations across cells of different types and between cells of the same type. This structural variation between single cells plays an important role in regulating single-cell specific transcription and epigenetic landscapes. Computationally reconstructing chromosomal 3D structure...
Published: 4/9/2025
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Inventor(s): Jianrong Wang, Jianliang Qian, Hao Wang
Keywords(s):
Category(s): Biotechnology, Computer Software
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3DVARIENTVISION: DECODE FUNCTIONAL IMPACTS OF GENETIC VARIANTS BASED ON 3D CHROMATIN
VAlue proposition
Deciphering the effects and mechanisms of genetic variants is essential to understand human genetics and further precision medicine. A genetic variant is a permanent change in the nucleotide sequence that makes up a gene, also known as a gene mutation. Mutations can cause diseases or phenotypic changes. Typically, Genome Wide Association...
Published: 4/9/2025
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Inventor(s): Jianrong Wang, Jiaxin Yang
Keywords(s):
Category(s): Medical, Biotechnology, Computer Software
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Light Scattering Fiber with Enhanced Side Emission for Photobioreactors
Executive Summary
Photobioreactors are used to cultivate various photosynthetic microorganisms to produce useful materials such as biofuels, value added chemicals. These systems regulate key factors including light, temperature, carbon dioxide concentration, and nutrients. A key challenge with photobioreactors is getting enough light into the medium...
Published: 4/3/2025
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Inventor(s): Xinyue Liu, Yijie Cheng
Keywords(s):
Category(s): Environmental, Chemicals, Biotechnology, Photonics
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The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses
Background
Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...
Published: 9/6/2024
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Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen
Keywords(s): Biomedical, Human Health, Pharma, Research, Veterinary Medicine
Category(s): Biotechnology, Biomedical, Pharma, Veterinary Medicine
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Reagents, Devices, and Accessories for Kinetic Fluorogenic Chemical Quantification
Background
Kinetic chromogenic (CG) and fluorogenic (FG) quantification deduces analyte concentration based on the reaction rate between the CG/FG probe and its targeted molecule. Little progress has been made in the past half century in either the theory or the applications of the kinetic spectroscopic quantification methods. Current kinetic CG/FG...
Published: 11/4/2024
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Inventor(s): Dongmao Zhang, Max Wamsley
Keywords(s): Biomedical, Chemicals, Food, Instruments, Materials, Military or Defense, Research
Category(s): Biomedical, Materials, Instruments, Biotechnology, Agriculture & Food Science
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mRNA Treatment to Induce Expression of Molecules to Prevent or Treat Tritrichomonas Foetus Infection in Bulls
Background
Bulls and cows are susceptible to reproductive system infection by the protozoal parasite Tritrichomonas foetus (T. foetus). Infected cows are unable to deliver healthy calves, and they can become infected by bulls that, despite showing no signs of the disease, are capable of transmitting the infection to cows. The failure of cows to deliver...
Published: 11/12/2024
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Inventor(s): Amelia Woolums, Elmer King, Merrilee Thoresen
Keywords(s): Veterinary Medicine
Category(s): Veterinary Medicine, Biotechnology
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A Method for Targeting Nanoparticles to Bacterial Biofilm Infections using Bacterial Surface Proteins
Background
Biofilm‑related infections are associated with high mortality and morbidity, combined with increased hospital stays and overall treatment costs. Traditional antibiotics play an essential role in controlling biofilms; however, they are becoming less effective due to the emergence of drug‑resistant bacterial strains. The need to treat biofilms...
Published: 10/2/2024
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Inventor(s): Nicholas Fitzkee, Dhanush Amarasekara
Keywords(s): Human Health, Materials, Medical Devices, Military or Defense, Nanotechnology and Nanoscience
Category(s): Biomedical, Biotechnology, Materials, Medical Devices, Pharma
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mRNA Therapy to Induce Expression of Molecules to Prevent or Treat Infectious Respiratory Disease in Cattle
Background
Infectious respiratory disease in cattle is the most common cause of sickness and death in many types of cattle in the United States and around the world. It is caused by one or more of multiple different viruses and/or bacteria.
Technology Overview
Bovine respiratory disease (BRD) is the leading cause of sickness and death in many types...
Published: 9/5/2024
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Inventor(s): Amelia Woolums
Keywords(s): Veterinary Medicine
Category(s): Veterinary Medicine, Biotechnology
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mRNA Treatment to Induce Expression of Relaxin for Reproductive Applications in Animals and Humans
Background
Female cattle and other animals, including humans, sometimes have trouble delivering their young (dystocia) at the time they are due because of inadequate relaxation or size of the mother's reproductive tract. Such situations can lead to difficult deliveries that may be harmful to the mother or the offspring. They may also require surgery...
Published: 9/9/2024
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Inventor(s): Peter Ryan, Amelia Woolums, Elmer King, Merrilee Thoresen, Federico Hoffmann
Keywords(s): Human Health, Veterinary Medicine
Category(s): Biotechnology, Veterinary Medicine
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