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Search Results - metabolic+diseases
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Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)
UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated
metabolic diseases
in humans. BACKGROUND: Obesity...
Published: 7/17/2025
|
Inventor(s):
Arpana Church
Keywords(s):
bacterial strain
,
brain reward system
,
brain-gut microbiome
,
food addiction
,
food metabolism
,
gut-brain axis
,
Mental health
,
Metabolic Diseases
,
Nutraceuticals / Probiotics
,
nutritional supplement
,
obesity
Category(s):
Therapeutics > Metabolism And Endocrinology
,
Therapeutics > Gastroenterology
,
Therapeutics > Psychiatry And Mental Health
AAV-Based Treatment of Guanidinoacetate Methyltransferase (GAMT) Deficiency (UCLA Case No. 2021-012)
SUMMARY: UCLA researchers in the Departments Molecular & Medical Pharmacology and Surgery in the David Geffen School of Medicine have developed a novel and tissue-specific gene therapy treatment for Guanidinoacetate methyltransferase (GAMT) deficiency. BACKGROUND: Guanidinoacetate Methyltransferase (GAMT) deficiency is caused by a mutation in...
Published: 7/17/2025
|
Inventor(s):
Gerald Lipshutz
Keywords(s):
Adeno-associated viruses (AAV)
,
Creatine
,
GAMT deficiency
,
Gene Therapy
,
Metabolic Diseases
Category(s):
Therapeutics > Gene Therapy And Editing
,
Therapeutics > Genetic Diseases
,
Therapeutics > Metabolism And Endocrinology
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024
|
Inventor(s):
Judith Fridovich-Keil
Keywords(s):
Animal Model
,
Enzyme/Protein
,
Genetic Disorders
,
Metabolic Diseases
,
Rare/Orphan Diseases
Category(s):
TechPub Algolia > Research Tools
2019-623 USE OF A NATURAL METABOLITE AS A CANCER THERAPY
UCLA Researchers in the Department of Chemistry and Biochemistry have devised a novel off label usage for the commonly available supplement s-adenylmethionine in the treatment of cancer.BACKGROUND: Tumor cells exhibit a wildly different metabolism from the tissue they are derived from. This altered metabolism allows sustained proliferation rates while...
Published: 7/17/2025
|
Inventor(s):
Steven Clarke
Keywords(s):
Metabolic Diseases
,
Oncology
,
Therapeutics & Vaccines
Category(s):
Therapeutics > Oncology
,
Therapeutics > Metabolism And Endocrinology
Smart Dialysis Catheter
UC Case No. 2019-873SUMMARY:UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.BACKGROUND:Kidney failure currently affects 660,000 Americans. 468,000 of these individuals...
Published: 2/14/2025
|
Inventor(s):
Asim Rafique
Keywords(s):
Bioinformatics
,
Cardiovascular
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Digital Health
,
Hospital Systems And Devices
,
Medical Devices and Materials
,
Metabolic Diseases
,
Monitoring And Recording Systems
,
Renal
,
Urology
Category(s):
Medical Devices > Monitoring And Recording Systems
,
Platforms > Diagnostic Platform Technologies
,
Therapeutics > Cardiovascular
2018-199 Identification of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, and Hepatic Fibrosis
Identification Of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, Hepatic FibrosisSUMMARYUCLA researchers in the Departments of Medicine and Human Genetics have identified a sequence of long, non-coding RNA that plays a role in the regulation of intracellular lipogenesis and holds potential for diagnosing and treating
metabolic diseases
,...
Published: 7/17/2025
|
Inventor(s):
Jihane Benhammou
,
Paivi Pajukanta
,
Joseph Pisegna
Keywords(s):
Diagnostic Markers & Platforms
,
Metabolic Diseases
,
Therapeutics & Vaccines
Category(s):
Diagnostic Markers
,
Therapeutics
,
Therapeutics > Metabolism And Endocrinology
2014-730 AGPAT5 as a Molecular Mediator of Insulin Resistance
AGPAT5 as a Molecular Mediator of Insulin ResistanceSUMMARYUCLA researchers in the Departments of Medicine and Cardiology have identified a novel gene and pathway in the regulation of insulin sensitivity and discovered an inhibitor of this gene useful for treating AGPAT5-related diseases.BACKGROUNDInsulin resistance (IR), a condition in which the body’s...
Published: 7/17/2025
|
Inventor(s):
Aldons Lusis
,
Brian Parks
,
Richard Lee
Keywords(s):
Cardiovascular
,
Diagnostic Markers & Platforms
,
Metabolic Diseases
,
Therapeutics & Vaccines
Category(s):
Diagnostic Markers
,
Therapeutics
,
Therapeutics > Cardiovascular
,
Therapeutics > Metabolism And Endocrinology
2018-354 TARGETING STEROL TRANSPORTERS IN METABOLIC DISEASE
SummaryUCLA researchers in the Department of Pathology have characterized a novel mechanism of cholesterol transport in mammalian cells between plasma membrane the ER. It is nonvesicular, lysosome independent and critical for lipid homeostasis.Background
Metabolic diseases
that involve metabolism of lipids, such as cholesterol, are typically inherited...
Published: 7/17/2025
|
Inventor(s):
Jaspreet Sandhu
,
Peter Tontonoz
Keywords(s):
Metabolic Diseases
,
Therapeutics & Vaccines
Category(s):
Therapeutics
,
Therapeutics > Metabolism And Endocrinology
Drug Repurposing to Explore Novel Treatment for Cushing Disease (UCLA Case No. 2019-621)
SummaryUCLA researchers in the Department of Medicine and the Department of Molecular and Medicinal Pharmacology have identified several small molecule reagents to treat Cushing disease.BackgroundCushing disease is a rare disease characterized by excessive adrenal-derived cortisol production, primarily as a result of adrenocorticotropic hormone (ACTH)-secreting...
Published: 7/17/2025
|
Inventor(s):
Anthony Heaney
Keywords(s):
Endocrinology
,
Life Science Research Tools
,
Metabolic Diseases
,
Targets And Assays
,
Therapeutics & Vaccines
Category(s):
Life Science Research Tools
,
Diagnostic Markers > Targets And Assays
,
Therapeutics
,
Therapeutics > Metabolism And Endocrinology
Normalization Method Simplifies Inter-Individual Comparisons
Application Normalization procedure that allows for the direct comparison of high-throughput liquid chromatography/mass spectrometry (LC/MS) metabolomic data gathered from different individuals at different times. Key Benefits Samples used can be collected at different times and/or analyzed by different mass spectrometers. Cumulative datasets...
Published: 12/4/2024
|
Inventor(s):
Dean Jones
,
Quinlyn Soltow
,
Jennifer Johnson
Keywords(s):
Chemistry
,
Metabolic Diseases
Category(s):
TechPub Algolia > Non-Therapeutics
,
TechPub Algolia > Diagnostics
,
TechPub Algolia > Research Tools
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