Search Results - transgenic

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Shoot Inducing Genes for Improved Production of Transgenic Plants
This invention, using Agrobacterium gene clusters, enables passive regeneration of transgenic cells without the need for plant hormones Background For plants which are recalcitrant (difficult) to transform, poor performance is usually associated with inadequate DNA delivery or difficult regeneration response. There is a need for improved methods...
Published: 9/5/2024   |   Inventor(s): Greg Goralogia, Steven Strauss
Keywords(s): Agrobacterium, Biotechnology, gene transfer, gene-edited, transgenic
Category(s): Agricultural
Longer-lived Mouse Models for Studying Gaucher Disease
The invention is a novel longer-lived mouse model for Gaucher disease. Gaucher disease is a genetic disorder that results from deficiencies in the enzyme glucocerebrosidase (GBA). The use of animal models to study how the disease progresses has been invaluable in research of this disorder. However, existing mouse models have been limited due to early...
Published: 10/28/2024   |   Inventor(s): Mary Lamarca, Edward Ginns
Keywords(s): ANIMAL, DISORDERS, Gaucher, Gaucher Disease, Human, IDXXXX, Inherited, Models, RXXXXX, TRANSGENIC, VHXXXX, VPXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XEXXXX
Category(s): Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology
Stopping Neurogenesis in Transgenic Mice and Rat Models that Express the HSV-thymidine kinase Gene in Neuronal Precursor Cells
This invention relates to novel mouse and rat models that permit the temporal death of neuronal precursor cells at any time point. Other existing methods of decreasing neurogenesis are relatively non-specific (e.g., injecting glucocorticoids) or require expensive equipment (e.g., focal x-irradiation) These mice and rats are being used to inhibit adult...
Published: 10/28/2024   |   Inventor(s): James Pickel, Heather Cameron
Keywords(s): Driving, Expression, GFAP, HSV, Kinase, Listed LPM Maddox as of 4/15/2015, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PROMOTER, RATS, Thymidine, TRANSGENIC, VEXXXX, WIXXXX, XEXXXX
Category(s): Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials
Mouse Model for Methylmalonic Acidemia, an Inherited Metabolic Disorder
Methylmalonic Acidemia (MMA) is a metabolic disorder affecting 1 in 25,000 to 48,000 individuals globally. MMA is characterized by increased acidity in the blood and tissues due to toxic accumulation of protein and fat by-products resulting in seizures, strokes, and chronic kidney failure. About 60% of MMA cases stem from mutations in the methylmalonyl...
Published: 10/28/2024   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Dysfunction, metabolic disorder, Methylmalonic acidemia, Methylmalonyl-CoA, methylmalonyl-CoA mutase, MITOCHONDRIAL, MMA, Model, Mouse, MUT, RENAL, RXXXXX, TRANSGENIC, transgenic mouse, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials
Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors
Researchers at NIH have generated transgenic mice in which the M3 muscarinic receptor is overexpressed in pancreatic beta cells. This was done by placing the receptor gene under the control of the 650 bp rat insulin promoter II (RIP II). The resulting mice show a pronounced increase in glucose tolerance and enhanced plasma insulin levels. Strikingly,...
Published: 10/28/2024   |   Inventor(s): Jurgen Wess
Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, Overexpressing, RECEPTORS, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials
Transgenic Mice with Constitutively Active M3 Muscarinic Receptor in Islet Beta Cells
Q490L point mutation was introduced into the rat M3 muscarinic receptor cDNA to confer persistent, constitutive (ligand-independent) activity. Expression of the M3 receptor mutant was placed under the control of a 650 bp fragment of the rat insulin promoter II (RIP II) to limit expression to the islet beta cell.
Published: 10/28/2024   |   Inventor(s): Jurgen Wess
Keywords(s): Active, Beta, Cells, CONSTITUTIVELY, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, RECEPTOR, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials
mNFHcre Transgenic Mice
Knockout mouse is a valuable model to study biological functions of target genes. When Cre expressing mice are bred with mice containing a loxP-flanked gene, the gene between the loxP sites will be deleted in the offsprings. Scientists at the NIH have generated mNF-H-cre transgenic mouse lines that express Cre recombinase under the control of the promoter...
Published: 10/28/2024   |   Inventor(s): Ashok Kulkarni
Keywords(s): Listed LPM Tong as of 4/15/2015, Mice, MNFHcre, MNHFcre, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RXXXXX, TRANSGENIC, VEXXXX, WIXXXX, XEXXXX, YCXXXX
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials
Transgenic Hspa2-Cre Mice for Studying Spermatogenesis and Male Infertility
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Hspa2-cre expression mimics the spermatogenic cell-specific expression of endogenous HSPA2 within the testis, being first observed in leptotene/zygotene spermatocytes. Expression of the transgene is also detected at restricted sites in the brain, as occurs...
Published: 10/28/2024   |   Inventor(s): Edward Eddy
Keywords(s): Cells, Cre, EXPRESSED, Gene, Generation, Hspa2, IDXXXX, IXXXXX, Line, Mouse, PROMOTER, Recombinase, REGULATION, Spermatogenesis, Spermatogenic, TRANSGENIC
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Transgenic Human Interleukin-21 Mouse Model
Available for licensing is a mouse model that constitutively expresses human interleukin-21 (IL-21). Traditionally, human IL-21 transgenic mouse models are difficult to produce as those with high IL-21 levels exhibit growth retardation and die before sexual maturity. The investigators generated transgenic mice that express human IL-21, which can stimulate...
Published: 10/28/2024   |   Inventor(s): Katsutoshi Ozaki, Warren Leonard
Keywords(s): AC5XXX, ACXXXX, AXXXXX, CCXXXX, CXXXXX, IDXXXX, IL-21, INTERLEUKIN, interleukin 21, IXXXXX, Mice, Mouse, Mouse animal model, mouse model, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
Transgenic Mice Expressing CNO-sensitive Gq- or Gs-coupled Designer Receptors Selectively in Pancreatic Beta Cells
Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. Beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The functional consequences of activating specific beta cell G protein signaling pathways in vivo are not well understood at present, primarily due to the fact that beta...
Published: 10/28/2024   |   Inventor(s): Jean-Marc Guettier, Jurgen Wess
Keywords(s): =, Beta-RASSL-1, Beta-RASSL-2, ID1XXX, Mice, RIPII-RQ, RIPII-Rs, TRANSGENIC, VFXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology, Application > Research Materials
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