Search Results - cns

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Stimulation of Parvalbumin Neurons to Enhance Recovery After Stroke (UCLA Case No. 2024-131)
UCLA researchers from the Department of Neurology have discovered a molecular compound that promotes activation of parvalbumin neurons in the brain, enhancing behavioral recovery after stroke. BACKGROUND: Stroke is a leading cause of death and disability worldwide. According to the World Health Organization, approximately 15 million people suffer from...
Published: 8/28/2024   |   Inventor(s): Stanley Carmichael
Keywords(s): Cns, Neurology, neuroscience, parvalbumin neurons, spinal cord, Stroke, stroke rehabilitation, stroke therapeutics
Category(s): Therapeutics > CNS and Neurology
A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)
Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...
Published: 1/24/2024   |   Inventor(s): Rhonda Voskuhl, Michael Jung
Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics
Device for Simulating Explosive Blast and Imaging Biological Specimens
Abstract: Traumatic brain injury (TBI) is a major health problem.  Between 3.2 and 5.3 million people live with long-term disabilities resulting from TBI, and thus, contribute to the need to develop therapies that treat TBI-induced cellular damage. Researchers at the National Institute of Child Health and Human Development (NICHD) have developed a device...
Published: 4/8/2024   |   Inventor(s): Rea Ravin, Paul Blank, Alex Steinkamp, Joshua Zimmerberg, Sergey Bezrukov, Kim Lee Mcafee
Keywords(s): Central Nervous System, CNS, explosive blast, National Institute of Child Health and Human Development, NICHD, SIMULATOR, TBI, Traumatic Brain Injury, Zimmerberg
Category(s): Application > Non-Medical Devices, Collaboration Sought > Collaboration, Application > Medical Devices, TherapeuticArea > Neurology, Collaboration Sought > Licensing
Therapeutics for Neurodegenerative Disorders and Cancer Using Lenalidomide Analogs
Abstract: Inflammatory processes associated with the over-production of tumor necrosis-alpha (TNF-alpha), a potent activator of the immune system accompany numerous neurodegenerative diseases. TNF-alpha has been validated as a drug target with the development of the inhibitors Enbrel and Remicade (fusion antibodies) as prescription medications. Both,...
Published: 4/8/2024   |   Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Harold Holloway, Qian-sheng Yu, Edward Goetzl
Keywords(s): CNS, Holloway, Immunomodulatory Agents, Inflammation, Lenalidomide, National Institute on Aging, Neurodegenerative Disorders, NIA, THALIDOMIDE, TNF-alpha, Tumor Necrosis-alpha
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Isotropic Generalized Diffusion Tensor MRI
Abstract: Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring...
Published: 4/8/2024   |   Inventor(s): Alexandru Avram, Peter Basser
Keywords(s): ADC, Basser, Central Nervous System, CNS, diffusion, Diffusion Weighted Images, Distribution, DWI, Fetus, High-Order Tensor, Image Analysis, Isotropic Diffusion Tensor Imaging, mADC, Mean Apparent Diffusion Coefficient, MRI Pulse Sequences, PATHOLOGY, Peripheral Nervous System, Placenta, PNS, STROKE, TRACE, Whole-Body
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Software / Apps
Methods of Determining Homeostatic Perturbations
Abstract: Biological homeostasis is a state of steady internal, physical, and chemical conditions maintained by a living organism observed at the cellular level.  Biological homeostasis can vary in order to alter the cellular physical and chemical conditions. Thus, it acts as a mechanism to define the physiological state of cellular activity; for instance...
Published: 4/8/2024   |   Inventor(s): Rea Ravin, Nathan Williamson, Teddy Cai, Peter Basser
Keywords(s): Basser, Biomarkers, Central Nervous System, CNS, functional imaging, HOMEOSTASIS, Magnetic Resonance Imaging, MRI, NICHD, NMR, Nuclear Magnetic Resonance, r, Steady-state, The Eunice Kennedy Shriver National Institute of Child Healt
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Diagnostics, Collaboration Sought > Licensing
2014-287 Minimally Invasive Implantable Brain Stimulation Devices And Methods For Implanting Same
SUMMARYUCLA researchers in the Department of Neurosurgery have developed a novel, minimally invasive deep-brain stimulation device concept.BACKGROUNDFor many patients suffering from a variety of movement and neuropsychiatric disorders, deep-brain stimulation (DBS) of select brain areas provides lasting relief for otherwise-treatment-resistant cases....
Published: 7/19/2023   |   Inventor(s): Itzhak Fried, Ilan Ben Oren, Tamir Wolf
Keywords(s): Cns, Medical Devices and Materials, Psychiatry / Mental Health
Category(s): Medical Devices, Therapeutics > CNS and Neurology, Therapeutics > Psychiatry And Mental Health
2020-426 PRODRUGS OF PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN
Researchers at UCLA have developed prodrugs of peripherally-acting cannabinoid (PRCBs) receptor agonists for chronic pain relief. BACKGROUND: Cannabinoids are becoming prevalent in chronic pain treatments even though current marketed cannabinoid compounds may cause psychotropic effects or central nervous system (CNS)-mediated side effects. A potential...
Published: 9/5/2023   |   Inventor(s): Igor Spigelman, Alexander Spokoyny, Herbert Seltzman
Keywords(s): Cns, Drug Delivery, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > CNS and Neurology
2020-408: sAPPalpha Targeted Therapeutics for Alzheimer’s Disease
UCLA researchers from the Department of Neurology have developed a novel application of two compounds that target the upstream formation of toxic amyloid-beta oligomers for the effective treatment of Alzheimer’s disease. BACKGROUND: Alzheimer’s Disease (AD) is the most common age-related neurodegenerative disorder currently affecting ~6...
Published: 7/19/2023   |   Inventor(s): Varghese John, Sujyoti Chandra
Keywords(s): Chemical, Cns, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > CNS and Neurology
2020-120 NOVEL MOUSE MODELS FOR GENETICALLY-DIRECTED SPARSE AND COMPLETE LABELING OF BRAIN CELLS FOR ANALYSIS OF BRAIN CELL BIOLOGY AND PATHOLOGY
Researchers in the Jane and Terry Semel Institute for Neuroscience and Human Behaviors at UCLA have developed four novel reporter mouse lines that illuminate morphologies of genetically-defined neurons and glia and can serve as novel platform for testing candidate therapeutics for neurodevelopmental, psychiatric and age-related brain diseases. The tools...
Published: 7/19/2023   |   Inventor(s): William Yang
Keywords(s): Animal Models, Cns, Diagnostic Markers & Platforms, Life Science Research Tools
Category(s): Life Science Research Tools > Animal Models, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology
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