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TESTING DEVICES

TESTING DEVICES Researchers at UCSF have developed new methods and a device for at home disease testing. At home testing for SARS-CoV2 using lateral flow technology has been integral to pandemic containment efforts across the globe. Lateral flow diagnostics in general are widely available in point-of-care settings, such as for viral or bacterial...

Published: 7/6/2023 | Inventor(s): Adam Abate, Charles Chiu, Krzysztof Langer, Daniel Weisgerber

Keywords(s): Diagnostics, Infectious Disease, LAMP, Lateral Flow Assay, PCR, Point-of-Care

Category(s): Technology Classifications > Biology

METHODS AND COMPOSITIONS FOR SELECTIVE PCR AND CLONING OF ANTIBODY SEQUENCES

METHODS AND COMPOSITIONS FOR SELECTIVE PCR AND CLONING OF ANTIBODY SEQUENCES Researchers at Stanford University and the CZ Biohub San Francisco have developed a strategy for retrieving and cloning antibody DNA from single cells within a pooled library of cells, enabling the rapid and low-cost cloning and expression of native human antibodies...

Published: 3/17/2023 | Inventor(s): Richard Horns, Stephen Quake

Keywords(s): Antibody, B Cells, cDNA Libraries, DNA Cloning, DNA Libraries, Molecular Cloning, PCR

Category(s): Technology Classifications > Biology

Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance

CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR)...

Published: 7/25/2024 | Inventor(s): Joshua Devos, Nicholas Wagar, Zhiyong Zhou, Chunfu Yang

Keywords(s): AIDS, assay, blood-borne, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DGHA, DA4AXX, DA4XXX, DAXXXX, DEVELOPING, Diagnosis, diagnostic, DRUG, drug resistance, drug resistant, DXXXXX, EMERGING, EPIDEMIOLOGIC, Genotype, Genotyping, Global, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resistance, RESISTANT, RT-PCR, Surveillance, therapeutic, tropical, viral, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

Real-Time PCR Assay for Detection of Carbapenem Antibiotic Resistance Genes of the IMP-type

Antibiotic resistance is one of the world's most pressing health concerns. ß-lactamases, such as carbapenemases, are enzymes produced by bacteria that provide resistance to multiple ß-lactam antibiotics (e.g., penicillins, cephamycins, and carbapenems) by breaking down the antibiotic molecules and deactivating their antibacterial properties. Carbapenems...

Published: 7/25/2024 | Inventor(s): Davina Campbell, Linda Karlsson

Keywords(s): assay, BlaIMP, Detection, GENES, NCEZID-DHQP, PCR, REAL-TIME, VJXXXX, WBXXXX, WFXXXX, WIXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Consumer Products, Application > Research Materials, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease

Real-time RT-PCR assay for Detection of Live Attenuated Influenza Vaccine for A and B Viruses

Upon intranasal vaccination, live attenuated influenza vaccine (LAIV) viruses may replicate within the nose for several days. Current clinical diagnostic tests cannot distinguish between LAIV viruses and multiple influenza viruses in recently inoculated patients that present with respiratory symptoms. This poses a problem for the diagnosis and treatment...

Published: 7/25/2024 | Inventor(s): Stephen Lindstrom, Kai-Hui Wu, LaShondra Berman, Christine Warnes, Bo Shu

Keywords(s): assay, Assays., Attenuated, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA4XXX, Detection, Human, Including, INFLUENZA, LAIV, LAIV-A, LAIV-B, Listed LPM Surabian as of 4/15/2015, Live, NCIRD-ID, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REAL-TIME, respiratory, RT-PCR, SPECIMENS, States., United, Vaccine, Viruses, VLXXXX, WBXXXX, WIXXXX, XEXXXX, XHXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment

Simple, Rapid, and Sensitive Real-Time PCR Assays for Detecting Drug Resistance of HIV

This novel assay features real-time PCR reagents and methods for detecting drug-resistance related mutations in HIV, for newly diagnosed patients and those individuals currently receiving antiretroviral therapies. As the use of antiretroviral compounds to treat HIV infection proliferates, viruses adapt and evolve mutations limiting the efficacy of...

Published: 7/25/2024 | Inventor(s): Jonathan Lipscomb, Walid Heneine, Jeffrey Johnson

Keywords(s): 1, ANTIVIRAL, Anti-Viral, ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4XXX, DAXXXX, DETECTING, DRUGS, DXXXXX, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, MUTATION, NCHHSTP-DHPSE, OID-NCHHSTP-DHPSE, PCR, POINT, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REAL-TIME, Resistance, VLXXXX, VPXXXX, WBXXXX, WFXXXX, XBXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Occupational Safety and Health, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology, Application > Research Materials, ResearchProducts > Computational models/software, Application > Consumer Products, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Nucleic Acid-based Differentiation and Identification of Medically Important Fungi

This invention, entailsnucleic acid-based assays, for detecting the presence of pathogenic fungi such as Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Pneumocystis brasiliensis, and/or Penicillium marneffei within a sample. Within a healthcare setting, this particular approach can greatly reduce pathogen identification time,...

Published: 7/25/2024 | Inventor(s): Zhenyu Qin, Jong Soo Choi, Christine Morrison, Mark Lindsley

Keywords(s): Acids, AIDS, Aspergilli, Aspergillus, CAPSULATUM, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, fungus, HIV, Identification, Methods, Mold, Molds, Nucleic, OID-NCEZID-DFWED, PCR, Probe, Probes, SAME, SECONDARY, secondary infection, thrush, VKXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Research Materials, ResearchProducts > Research Equipment, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples

This invention relates to detecting Histoplasma capsulatum by PCR using oligonucleotide probes specific for the fungus. Histoplasmosis is a mycotic infection of varying severity, usually localized in the lungs. Caused by H. capsulatum, infections are usually symptomatic but can develop into chronic disease, especially in immunocompromised individuals. Test...

Published: 7/25/2024 | Inventor(s): Thomas Reid, Millie Schafer

Keywords(s): AA5XXX, AAXXXX, AIDS, assay, Avian, AXXXXX, CAPSULATUM, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, fungus, HISTOPLASMA, Histoplasmosis, HIV, Method, NESTED, NIOSH-DART, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, PATHOGEN, PATHOGENIC, PATHOGENS, PCR, PCR ASSAY, RAPID, SENSITIVE, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Therapeutics

Species-specific Nucleic Acid Detection Assay for Fungi

This invention pertains to nucleic acid-based assays for the detection of Aspergillus and other filamentous fungi. Assays cover the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporthrix in a subject. This can reduce identification time from...

Published: 7/25/2024 | Inventor(s): Errol Reiss, Lilianna Aidorevich, Jong Soo Choi, Christine Morrison

Keywords(s): Acids, Aspergillus, CANDIDA, CANDIDA ALBICANS, candidiasis, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, I-016-96, I-016-96/0, Mold, Molds, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, OID-NCEZID-DFWED, PCR, PCR ASSAY, PRIMERS, Species, VKXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology

Human Influenza Virus Real-time RT-PCR Detection and Characterization Panel

This invention relates to methods of rapidly detecting influenza, including differentiating between type and subtype. Unlike culture and serological tests requiring 5 to 14 days for completion, CDC researchers developed a rapid, accurate assay, which is easily adapted to kit form. This assay also requires less labor input than immunoassays. These...

Published: 7/25/2024 | Inventor(s): Alexander Klimov, Nancy Cox, Lamorris Loftin, Stephen Lindstrom

Keywords(s): Avian, Avian flu, Avian influenza, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DEVELOPED, DEVELOPING, Discriminate, discrimination, DXXXXX, INFLUENZA, PCR, PRIMERS, Probes, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, RT-PCR, Serotypes, SUBTYPES, Swine, tropical, Types, VETERINARY, viral, virus, Viruses, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Consumer Products, Application > Occupational Safety and Health, Application > Diagnostics, Application > Research Materials

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