Search Results - virus

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Microbial Air Quality Monitoring System (MAQMS)
Air quality monitoring is critical for environmental health and public safety. Traditional monitoring methods rely on passive and active air sampling techniques, which, while effective, are cumbersome, expensive and limited with respect to real-time data and comprehensive analyses. In high-risk environments, such as hospital or care settings, and food...
Published: 5/19/2025   |   Inventor(s): Amir Elyaderani
Keywords(s): CO2 sensor, Early Detection, Environmental, Informatics, PS-Bioengineering, Medical, Sensors, PS-Environmental, Public Health Technology, Real-Time System, Viral, Virus
Category(s): Artificial Intelligence/Machine Learning, COVID-19, Life Science (All LS Techs), Intelligence & Security, Environmental
Highly Sensitive RSV Reporter Tools for Anti-Viral Drug Discovery
Description This technology is a series of innovative RSV reporter tools for high throughput screening of anti-viral drug candidates. Our reporter tools offer innovative solutions for RSV drug discovery and vaccine development, with improved sensitivity and robustness compared to conventional fluorescent assays. Additionally, these tools are simplified,...
Published: 3/24/2025   |   Inventor(s): Richard Plemper
Keywords(s): Virus
Category(s): Research Tool
Targeted Lentiviral Transduction of B-Cells With Desired B-Cell Receptor Specificity (UCLA Case No. 2023-237)
UCLA researchers in the Division of Hematology and Oncology in the Department of Medicine, have discovered novel lentiviral vectors that can be used for gene delivery to B-cells and for the development of neutralizing antibodies against viruses. BACKGROUND: Microbial tropism is a microbiology term that describes the types of animals (including human),...
Published: 2/14/2025   |   Inventor(s): Koki Morizono
Keywords(s): B Cell, cell receptor, COVID-19, VIral entry, Virus
Category(s): Therapeutics > Immunology And Immunotherapy
Sensitive and Economic RNA Virus Detection Using a Novel RNA Preparation Method
Abstract: DNA or RNA-based diagnostic tests for infectious diseases are critical in modern medicine. The current gold standard for COVID-19 detection is testing SARS-CoV-2 viral RNA by quantitative reverse transcription Polymerase Chain Reaction (RT-qPCR). This method involves patient sample collection with a nasopharyngeal swab, storage of the swab...
Published: 5/15/2025   |   Inventor(s): Bin Guan, Robert Hufnagel
Keywords(s): Biomarker, Chelating Resin, Chelex Resin, COVID, COVID-19, DNA/RNA diagnostic test, Extraction-free Detection, Infectious Diseases, SARS-CoV-2, virus
Category(s): TherapeuticArea > Oncology, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
Nanobodies Neutralizing Lassa Virus
Abstract: Lassa Hemorrhagic Fever (LHF) is a serious disease caused by infection with Lassa virus (LASV) – highly prevalent in West Africa and spreading globally. LASV is associated with high morbidity and mortality rates, annually infecting 100,000 to 300,000 individuals and causing 5,000 deaths. Developing prophylactics and treatment for LASV is difficult...
Published: 5/14/2025   |   Inventor(s): Mitchell Ho, Peter Kwong, Zhijian Duan, Yaping Sun, Sao Cheung, Jason Gorman
Keywords(s): antibodies, diagnostic, HO, LASSA, Lassa Hemorrhagic Fever, LHF, Nanobodies, Neutralizing, virus
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease
Therapeutics Against Pathogenic Coronaviruses
Abstract: The COVID-19 pandemic is a worldwide public health crisis with over 440 million confirmed cases and 6.0 million deaths as of March 2022. COVID-19 is caused by a novel coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While there are several vaccines available for COVID-19, there are few therapeutics available...
Published: 4/22/2025   |   Inventor(s): Melvin DePamphilis, Matthew Frieman, Arup Chakraborty
Keywords(s): CORONAVIRUS, COVID-19, Depamphilis, Eunice Kennedy Shriver National Institute of Child Health an, Infectious Diseases, MER-CoV, NICHD, PIKfyve Phosphatidyl Linositol Kinase Inhibitors, SARS-CoV, SARS-CoV-2, virus
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease
Repurposing CDK Inhibitors for the Treatment of Zika Virus Infection
This invention includes the discovery and use of a group of CDK inhibitors that were found during a drug repurposing screen designed to find compounds that inhibit Zika virus caused cell death. The identified CDK inhibitors have all previously been used in clinical trials for other diseases, potentially reducing the long time course needed for new drug...
Published: 10/28/2024   |   Inventor(s): Ruili Huang, Miao Xu, Wenwei Huang, Hengli Tang, Emily Lee, Cheng YiChen, Yi Zhou, Hongjun Song, Guo-Li Ming, Zhexing Wen, Wei Zheng
Keywords(s): CDK, Infection, Inhibitors, Repurposing, treatment, VEXXXX, virus, VLXXXX, WIXXXX, WKXXXX, Zika
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Mononegavirales Vectors Expressing Chimeric Antigens
Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide, and also is an important cause of morbidity and mortality in the elderly. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use...
Published: 10/28/2024   |   Inventor(s): Linda Brock, Ursula Buchholz, Peter Collins, Shirin Munir
Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Improved Live-Attenuated Vaccine for Respiratory Syncytial Virus (RSV) Bearing Codon-Pair Deoptimized NS1, NS2, N, P, M and SH Genes and Additional Point Mutations in the P Gene
RSV is the most important viral agent of severe respiratory disease in infants and young children worldwide and also causes substantial morbidity and mortality in older adults. RSV is estimated to cause more than 33 million lower respiratory tract illnesses, three million hospitalizations, and nearly 200,000 childhood deaths worldwide annually, with...
Published: 10/28/2024   |   Inventor(s): Cyril Le Nouen, Ursula Buchholz, Peter Collins
Keywords(s): ADDITIONAL, BEARING, Codonpair, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deoptimized, DXXXXX, GENES, Improved, Live-Attenuated, M, Mutations, N, NS1, NS2, P, Pgene, POINT, respiratory, RSV, SH, Syncytial, Vaccine, virus
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Epstein-Barr Virus Antibody That Blocks Fusion And Neutralizes Virus Infection of B Cells
Epstein-Barr virus (EBV) is the most common cause of infectious mononucleosis and is associated with nearly 200,000 cancers and 140,000 deaths each year. EBV-associated cancers include Hodgkin's lymphoma, non-Hodgkin's lymphoma, Burkitt B cell lymphoma, and EBV post-transplant lymphoproliferative disease. The latent reservoir for EBV in the body is...
Published: 10/28/2024   |   Inventor(s): Wei Bu, Nathan Board, Kennichl Dowdell, Jeffrey Cohen
Keywords(s): ANTIBODY, B, BLOCKS, Cells, DAXXXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DCXXXX, DDXXXX, DXXXXX, EPSTEIN-BARR, Fusion, Infection, Neutralizes, That, virus
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease
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