Search Results - sequencing

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Swabseq Agnostic Diagnostic Platform (Case No. 2023-293)
Summary: UCLA researchers in the Departments of Computer Science and Anatomic Pathology have developed an untargeted NGS diagnostic tool capable of detecting all known and emerging respiratory RNA viruses in a single test, enhancing our capacity to rapidly address public health crises through improved diagnostics. Background: Most clinical diagnostic...
Published: 9/17/2024   |   Inventor(s): Eleazar Eskin, Valerie Arboleda
Keywords(s): agnostic detection, Bioinformatics, bioinformatics pipeline, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Test, DNA Sequencing, Medical diagnostics, metagenomic diagnostic platform, meta-genomics, next generation sequencing (NGS), Pathogen, Pathogenesis, Sequencing
Category(s): Platforms, Platforms > Diagnostic Platform Technologies, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics
SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS Researchers at UCSF have developed methods for sequencing a single cell from a cell culture sample and obtaining morphologic or phenotypic measurements and information by combining sequencing approaches and spatial hashing (e.g. barcoding) at a single cell level. There exists a need in...
Published: 7/27/2023   |   Inventor(s): Kai-Chun Chang, Adam Abate
Keywords(s): Lipid-Modified, Oligonucleotides, Sequencing, Single Cell
Category(s): Technology Classifications > Biology
PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING
PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING Researchers at UCSF have developed a method for high throughput single-cell multi-omic sequencing that is rapid, simple to operate, and offers key innovations over existing technologies. Single-cell sequencing technologies refer to the methods to obtain genomics, transcriptomics or multi-omics...
Published: 4/20/2023   |   Inventor(s): Adam Abate, Xiangpeng Li, Benjamin Demaree
Keywords(s): Genomic DNA, Hydrogel, Microfluidic, Partitioning, Sequencing, Single-Cell, Transcriptomics
Category(s): Technology Classifications > Biology
Processing-In-Memory (PIM) Platform for mRNA Quantification
­The study of human genetics is a rapidly expanding field, fueled in part by developments in large-scale protein and genomic sequencing technologies. Biopharmaceutical companies and modern healthcare rely heavily on sequencing technologies and the acquired data to develop new drugs and provide effective treatments to patients. However, the results...
Published: 2/23/2023   |   Inventor(s): Deliang Fan, Fan Zhang, Shaahin Angizi
Keywords(s): Algorithm Development, Biomarker discovery, Computing Architecture, DNA and protein sequencing, Genomics, Proteomics, Sequencing
Category(s): Physical Science, Computing & Information Technology, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a massive scale. NIEHS researchers developed a massively paralleled multiplexed screening method using next generation sequencing (NGS). This method uses...
Published: 10/28/2024   |   Inventor(s): Brian Papa, Oswaldo Lozoya
Keywords(s): Acid, assay, DA4BXX, Diagnosis, HOST, Infection, Massively, Multi-patient, Nucleic, Paralleled, PATHOGENIC, PHYSIOLOGY, sequencing, Surveillance, VLXXXX, WBXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics
Novel Live-Attenuated Rabies Vaccine
The critical feature of this technology is the Evelyn-Rokitnicki-Abelseth (ERA) rabies whole genome DNA sequence. With the availability of the entire rabies genome, a recombinant vaccine can be developed using reverse genetics. Using this technology, CDC researchers have developed a recombinant, live-attenuated vaccine shown to confer protection against...
Published: 10/28/2024   |   Inventor(s): Xianfu Wu, Charles Rupprecht
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Genome, Genomes, Method, OID-NCEZID-DHCPP, RELATED, Sequences, sequencing, viral, Whole
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines
2022-084 HUMAN LEUKOCYTE ANTIGEN HAPLOTYPE ANALYSIS TOOLKIT (HLA-HAT)
SUMMARY: UCLA researchers in the department of Medicine, Hematology and Oncology have developed software which facilitates the clinically relevant investigation of genetic antigen heterogeneity within human leukocytes BACKGROUND: Human leukocyte antigen system is a critical component of the immune system. A major part of this is a series of genes...
Published: 9/19/2024   |   Inventor(s): Katie Campbell
Keywords(s): Algorithm, Allele, Autoimmune Disease, Bioinformatics, Biotechnology, CD3 (Immunology) Human Leukocyte Antigen, Functional Genomics, Genetic Algorithm, Genetic Testing, Immunology, Inflammation, Instrumentation & Analysis, Sequencing, Software, Software & Algorithms
Category(s): Life Science Research Tools, Software & Algorithms, Software & Algorithms > Bioinformatics
2021-255 Benchmarking Computational Doublet-detection Methods For Single-cell RNA Sequencing Data
SUMMARY: UCLA researchers in the Department of Statistics have developed a software to compare existing doublet detection algorithms for Single-Cell RNA Sequencing Data. BACKGROUND: Single-cell RNA sequencing (scRNA-seq) provides the expression profiles of individual cells and is considered the gold standard for defining cell states and phenotypes...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Algorithm, DNA Sequencing, Error Detection And Correction, Nucleotide, Polymorphism (Biology), RNA, RNA-Seq, Sequencing, Software, Software & Algorithms
Category(s): Software & Algorithms, Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Software & Algorithms > Programs
Precise, Accurate Bacterial Identification System
This technology is a rapid, whole genome sequence analysis tool to determine the type of bacteria, resistance, and virulence that lacks biases introduced by culture-based methods. Background: The lack of accurate and precise methods to identify bacteria forces clinicians to use broad based antibiotic regimens. Unfortunately, only 20-40% of samples...
Published: 4/3/2023   |   Inventor(s): George Watts, Bonnie Hurwitz
Keywords(s): bacteria, clinical, database, infection, k-mer, sequencing
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics