Search Results - dna

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UNAFold® - Software suite for simulating and predictig nucleic acid folding, hybridization, and melting behavior
RPI ID: 2017-042 Innovation Summary: UNAFold® is a comprehensive software suite designed to simulate and predict nucleic acid folding, hybridization, and melting behavior using experimentally derived free energy parameters. It models secondary structures of single-stranded DNA or RNA, either individually or in pairs, under customizable temperature...
Published: 4/27/2026   |   Updated: 12/22/2025   |   Inventor(s): Nicholas Markham, Michael Zuker
Keywords(s): Bioinformatics, Biotechnology, Design, Diagnostics, discovery tool, DNA, healthcare, Human healthcare, modeling and simulation, molecular beacon, Molecular Biology, Molecular diagnostics, Nucleic acids, PCR primer, pharmaceutical, RNA, Software
Category(s): Biotechnology and the Life Sciences
Portable Assay for COVID-19 Diagnostic
A low-cost, rapid, and more accurate gel electrophoresis-based assay using DNA nanoswitches for detecting COVID-19 and other viruses. Background: Viral diagnostics are of prime importance for testing infection rates and for timely treatment, especially in the case of a pandemic such as the current COVID-19 outbreak caused by the SARS-CoV-2 corona...
Published: 4/17/2026   |   Updated: 10/24/2025   |   Inventor(s): Kenneth Halvorsen, Lifeng Zhou
Keywords(s): DNA, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics
Ribonuclease-responsive DNA Nanoswitches
A DNA nanoswitch that provides a simple mix-and-read methodology to detect RNases (ribonucleases) in a biological sample. Background: RNases are involved in many biological processes including neurotoxicity, genome replication and maintenance, immune-suppression, and antitumor activity. RNase inhibitors are also potential drug candidates and biomarkers...
Published: 1/30/2026   |   Updated: 10/24/2025   |   Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran
Keywords(s): DNA, RNA, RNA-switch
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents, Technology Classifications > Diagnostics
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 1/30/2026   |   Updated: 10/24/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 1/30/2026   |   Updated: 10/24/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
Determining the Donor Age Based on Raman Spectroscopy of a Bloodstain
Novel methodology helps forensic investigators determine victim's age from bloodstains. Background: In the absence of a body at a crime scene, forensic investigators must rely on whatever biological material is left behind to determine the sex, race, and age of perpetrators and victims. That often means analyzing stains like blood, sweat, and...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Igor Lednev
Keywords(s): biological, blood, blood based technology, crime scene analysis, DNA, evidence collection, forensic tool, forensics, laboratory blood test, Raman spectroscopy, raman system, spectroscopy, TAF, Technologies, trace evidence
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics
Argon to Improve Bioanalyte Stability in Fixed Tissue Specimens
Abstract: The degradation of archival surgical and biospecimen limits the utility of many biomarkers that may have prognostic or predictive significance in guiding a patient’s therapy. Previous methods at preventing the degradation of RNA and proteins in formalin fixed, paraffin embedded (FFPE) tissue blocks & slides have no protective benefit.  Researchers...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Stephen Hewitt, Vasuhi Rasanayagam, Joon-Yong Chung, Sagar Joshi, Meenakshi Sundar
Keywords(s): Anatomic Pathology Tissue Handling Improvements, ARGON, DNA, FFPE, formaldehyde, Formalin Fixed Paraffin Embedded, Hewitt, Paraffin Embedded, RNA
Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
ABI1 Regulates Transcriptional Activity of Androgen Receptor by Novel DNA and AR Binding Mechanism
Provides new pathways for biomarkers and drug discovery for cancer patients. Background: The gene Abelson interactor protein-1 (ABI1) encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal...
Published: 3/18/2026   |   Updated: 7/7/2023   |   Inventor(s): Leszek Kotula, Alaji Bah, Dominique Frueh
Keywords(s): DNA, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
Resurfaced Stabilized Core 3 (RSC3) Protein, Derived Proteins, and DNA Encoding These Proteins: RSC3, RSC3 delta371I, RSC3 delta371I/P363N, RSC3 G367R
Details for these materials may be found in the NIH AIDS Reagent Program Catalog – RSC3 (Catalog# 12042): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=214 RSC3 delta371I (Catalog# 12043): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=146 RSC3 delta371I/P363N (Catalog# 12362): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=145 RSC3...
Published: 8/13/2025   |   Updated: 12/6/2022   |   Inventor(s): Tongqing Zhou, Gary Nabel, Zhi-yong Yang, Ling Xu, Peter Kwong
Keywords(s): 3, Core, DERIVED, DNA, Encoding, Protein, proteins, Resurfaced, RM, RSC3, Stabilized, THESE, WIXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials
Real-time PCR Assay for Detection of Pneumococcal DNA and Diagnosis of Pneumococcal Disease
CDC scientists have developed a real-time PCR assay for diagnosing pneumococcal disease using amplification of the bacterial gene encoding pneumococcal surface adhesin A (PsaA). Pneumococcal isolation and identification is often complicated by 1) antimicrobial suppression of growth in culture and 2) contamination by normal flora alpha-streptococci....
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Edwin Ades, George Carlone, Karen McCaustland, Maria Da Gloria Carvalho, Jacquelyn Sampson
Keywords(s): assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, Detection, Development, Diagnosis, Disease, DNA, DXXXXX, PCR, PNEUMOCOCCAL, REAL-TIME
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics
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