Search Results - drug+resistance

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Parental A2780 Ovarian Cancer Cell Line and Derivative Cisplatin-resistant and Adriamycin-resistant A2780 Cell Lines
Abstract: Ovarian cancer is one of the most common and lethal types of gynecological malignancies worldwide, accounting for approximately 295,000 new cases and 185,000 deaths annually. The high lethality rate is due to multiple reasons, including recurrence and the resistance of recurrent tumors to chemotherapy. Cell line models are crucial for preclinical...
Published: 4/8/2024   |   Inventor(s): Stuart Aaronson, Nelson Ellmore
Keywords(s): A2780, Aaronson, adriamycin, CISPLATIN, drug resistance, IRRADIATION, Melphalan, OVARIAN CANCER, VINBLASTINE
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials
Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance
CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR)...
Published: 7/25/2024   |   Inventor(s): Joshua Devos, Nicholas Wagar, Zhiyong Zhou, Chunfu Yang
Keywords(s): AIDS, assay, blood-borne, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DGHA, DA4AXX, DA4XXX, DAXXXX, DEVELOPING, Diagnosis, diagnostic, DRUG, drug resistance, drug resistant, DXXXXX, EMERGING, EPIDEMIOLOGIC, Genotype, Genotyping, Global, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resistance, RESISTANT, RT-PCR, Surveillance, therapeutic, tropical, viral, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics
2022-223 A Bioanalytics-Enabled and Hollow Microneedle-Based Wearable Technology for Personalized Medicine
­Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a minimally-invasive wearable device that continuously monitors pharmaceutical concentrations in a user to optimize the drug’s dosage. Background: The annual cost of medication-related morbidity and mortality due to non-optimized pharmacotherapy...
Published: 7/19/2023   |   Inventor(s): Sam Emaminejad, Shuyu Lin
Keywords(s): Adverse Drug Reaction, Antibody-Drug Conjugate, Antiviral Drug, Biomonitoring, Blood Glucose Monitoring, Drug, Drug Carrier, Drug Delivery, Drug Delivery Microporous Material, Drug Development, Drug Development Feature Extraction, Drug Discovery, Drug monitoring, Drug Resistance, Drug-Eluting Stent, Extensively Drug-Resistant Tuberculosis, Fine-Needle Aspiration, Gene Combination Drug, Immunosuppressive Drug, interstitial fluid (ISF)-based information, Investigatioal New Drug, Management Of HIV/AIDS Psychoactive Drug, medical automation technology, Medical Device, Medical Devices and Materials, medication customization, medication efficacy, Microneedle array, minimally invasive device, Monitoring (Medicine), Monitoring And Recording Systems, Multiple Drug Resistance, Mutation Drug Design, Nanosensor, Nanostructure, Nanotechnology, non-invasive drug monitoring, personalized dose assessment, Pharmaceutical Drug, Pharmaceutical Drug Ethylene Glycol, Pharmaceutical Drug Opioid Dependence, Prescription Drug, real-time sensing/monitoring/tracking, remote monitoring, sample-to-answer devices, Smart medical device, Therapeutic Drug Monitoring, wearable medical device
Category(s): Mechanical, Mechanical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Software & Algorithms > Bioinformatics, Software & Algorithms > Artificial Intelligence & Machine Learning, Electrical > Sensors, Materials > Nanotechnology
2022-222 A Wearable Aptamer Microneedle Patch for Continuous Minimally-Invasive Biomonitoring
Summary: UCLA researchers in the Department of Bioengineering have developed a novel wearable device for real-time, minimally-invasive medication monitoring. Background: Current medication dosing is determined by taking the average therapeutic dose of a small patient sample size. However, this is often inaccurate for many individuals and the recommended...
Published: 8/2/2024   |   Inventor(s): Sam Emaminejad, Shuyu Lin, Jialun Zhu, Xuanbing Cheng
Keywords(s): Biomonitoring, Drug, Drug Delivery, Drug Development, Drug Discovery, Drug Resistance, Invasiveness Of Surgical Procedures, Microneedle array, non-invasive drug monitoring, Personalized Pharmacotherapy, Pharmaceutical Drug, Pharmacokinetics, Pharmacology, Prescription Drug, Therapeutic Drug Monitoring, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Medical Devices, Materials > Nanotechnology
Cellphone-Based Micro-Plate Reader for Point-Of-Care ELISA Testing & High-Throughput and Automated Diagnosis of Antimicrobial Resistance
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a cost-effective cellphone-based micro-plate reader to rapidly perform antimicrobial susceptibility testing (AST) with >99% accuracy. Background: Immunoassays are biochemical tests that are conducted to measure the presence and concentration of...
Published: 7/19/2023   |   Inventor(s): Aydogan Ozcan, Dino Di Carlo, Steve Feng, Bingen Cortazar Unzaga, Brandon Berg, Haydar Ozkan, Omai Garner, Kuochao Tseng
Keywords(s): Antibacterial, Antibiotic Resistance, Antibody, Artificial Intelligence, Bacteria, Drug Resistance, ELISA, High-Throughput Screening, Immunoassay, Nanotechnology, Optics, Photonics, Point Of Care, Smartphone
Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Optics & Photonics, Software & Algorithms > Artificial Intelligence & Machine Learning