Search Results - da4bxx

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A Diagnostic Kit for Assessing Exposure or Infection by the Koala Family of Retroviruses
This invention relates to a diagnostic kit for assessing exposure to or infection by a koala retrovirus. The kit consists of specific primers and probes for the detection of three distinct subtypes of infectious koala retrovirus and may be useful in various species, including humans, primates, and koalas. A family of infectious koala retroviruses are...
Published: 10/28/2024   |   Inventor(s): Wenqin Xu, William Switzer, HaoQiang Zheng, Maribeth Eiden
Keywords(s): ASSESSING, CA1AXX, DA4BXX, diagnostic, Exposure, FAMILY, Gammaretroviruses, Infection, KIT, Koala, Listed LPM Maddox as of 4/15/2015, Ofgammaretroviruses, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, VCXXXX, VLXXXX, VOXXXX, WBXXXX, XCXXXX
Category(s): Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials
Mononegavirales Vectors Expressing Chimeric Antigens
Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide, and also is an important cause of morbidity and mortality in the elderly. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use...
Published: 10/28/2024   |   Inventor(s): Linda Brock, Ursula Buchholz, Peter Collins, Shirin Munir
Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Improved Live-Attenuated Vaccine for Respiratory Syncytial Virus (RSV) Bearing Codon-Pair Deoptimized NS1, NS2, N, P, M and SH Genes and Additional Point Mutations in the P Gene
RSV is the most important viral agent of severe respiratory disease in infants and young children worldwide and also causes substantial morbidity and mortality in older adults. RSV is estimated to cause more than 33 million lower respiratory tract illnesses, three million hospitalizations, and nearly 200,000 childhood deaths worldwide annually, with...
Published: 10/28/2024   |   Inventor(s): Cyril Le Nouen, Ursula Buchholz, Peter Collins
Keywords(s): ADDITIONAL, BEARING, Codonpair, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deoptimized, DXXXXX, GENES, Improved, Live-Attenuated, M, Mutations, N, NS1, NS2, P, Pgene, POINT, respiratory, RSV, SH, Syncytial, Vaccine, virus
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a massive scale. NIEHS researchers developed a massively paralleled multiplexed screening method using next generation sequencing (NGS). This method uses...
Published: 10/28/2024   |   Inventor(s): Brian Papa, Oswaldo Lozoya
Keywords(s): Acid, assay, DA4BXX, Diagnosis, HOST, Infection, Massively, Multi-patient, Nucleic, Paralleled, PATHOGENIC, PHYSIOLOGY, sequencing, Surveillance, VLXXXX, WBXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics
Mononegavirales Vectors expressing Chimeric Antigens
Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use of murine pneumonia virus (MPV), a virus to which humans normally are not...
Published: 10/28/2024   |   Inventor(s): Peter Collins, Ursula Buchholz, Linda Brock, Shirin Munir
Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease
Development of a Transferrable Norwalk Virus Epitope and Detector Monoclonal Antibody
Noroviruses are now recognized as the major cause of non-bacterial gastroenteritis in all age groups, and efforts are underway to develop an effective vaccine. The lack of a robust cell culture system for human noroviruses has complicated vaccine development. Hence, norovirus virus like particles (VLPs) have played an important role in the understanding...
Published: 10/28/2024   |   Inventor(s): Stanislav Sosnovtsev, Karin Bok, Carlos Sandoval-Jaime, Eugenio Abente, Gabriel Parra Gonzalez, Lisbeth Kim Green
Keywords(s): ANTIBODY, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DETECTOR, DetectorMonoclonal, Development, DEXXXX, DXXXXX, Epitope, Listed LPM Fenn as of 4/15/2015, monoclonal, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Transferrable, virus, VLXXXX, WBXXXX, WIXXXX, XAXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Infectious Disease
Novel Enzyme-Based Immunoassay for Simultaneous Detection of Hepatitis C Virus Antigen and Antibody in Human Serum or Plasma
CDC scientists have developed a novel enzyme immunoassay for the simultaneous detection of hepatitis C virus (HCV) core antigen and circulating HCV antibodies. Serological testing procedures for HCV circulating antibodies are well established. There is, however, a window of time between HCV infection and seroconversion that generates an opportunity...
Published: 10/28/2024   |   Inventor(s): Yury Khudyakov
Keywords(s): ANTIBODY, Antibody-based, Antibody-dependent, ANTIGEN, Antigen Antibody, ANTIGEN CAPTURE ASSAY, Antigen/Ab, Antigen/antibody, ANTIGEN-ANTIBODY, Antigen-binding, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, Detection, detection system, Diagnosis, diagnostic, diagnostic in vitro, Diagnostic Kit, EIA, HCV, Hepatitis, HEPATITIS C, HEPATITIS C DIAGNOSTIC, HEPATITIS C HCV, Human, ivd, LATERAL, Novel, OID-NCHHSTP-DVH, PLASMA, SERA, SIMULTANEOUS, viral, VIRAL DIAGNOSTIC, virus, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XAXXXX, XCXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Consumer Products, Application > Diagnostics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies
Human Influenza Virus Real-time RT-PCR: Detection and Discrimination of Influenza A (H3N2) Variant from Seasonal Influenza A (H3N2) Viruses, Including H3v and Seasonal H3 Assays
This invention relates to methods of rapidly detecting influenza, including differentiating between type and subtype. CDC researchers have developed a rapid, accurate, real-time RT-PCR assay that has several advantages over culture and serological tests, which require 5 to 14 days for completion; this assay can also be easily implemented in kit form....
Published: 10/28/2024   |   Inventor(s): Stephen Lindstrom, Kai-Hui Wu, LaShondra Berman, Bo Shu
Keywords(s): assay, ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, CIRCULATING, DA4BXX, DA4XXX, DAXXXX, Detection, diagnostic, Diagnostic assay, diagnostic in vitro, discrimination, DXXXXX, Flu, H3, H3N2, H3v, Including, INFLUENZA, ivd, Pandemic, REAL-TIME, RT-PCR, Seasonal, VARIANT, virus, Viruses, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Research Materials, Application > Diagnostics
Multiple Antigenic Peptide Assays for Detection of HIV and SIV Type Retroviruses
CDC scientists have developed multiple antigenic peptide immunoassays for the detection of human immunodeficiency virus (HIV) and/or simian immunodeficiency virus (SIV). HIV can be subdivided into two major types, HIV-1 and HIV-2, both of which are believed to have originated as result of zoonotic transmission. Humans are increasingly exposed to...
Published: 10/28/2024   |   Inventor(s): Clement Ndongmo, Chou-Pong Pau, William Switzer, Thomas Folks, Marcia Kalish
Keywords(s): ANTIGENIC, assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DXXXXX, HIV, MULTIPLE, OID-NCHHSTP-DHPSE, Peptide, Retroviruses, Serologic, SEROLOGICAL, SIV, TYPE, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, ResearchProducts > Antibodies, Application > Therapeutics
Methods for the Simultaneous Detection of Multiple Analytes
CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific...
Published: 10/28/2024   |   Inventor(s): George Carlone, Joseph Martinez
Keywords(s): AA5XXX, AAXXXX, ANALYTES, AXXXXX, Bead, Beads, CA1BXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, Detection, flow cytometer, flow cytometry, IAXXXX, IMMUNOASSAY, Methods, MULTIPLE, SIMULTANEOUS, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies, Application > Occupational Safety and Health
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