Search Results - cardiovascular+diseases

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Synchronized Biventricular Heart Pacing Using Wirelessly Powered Leadless Pacemakers (Cases 2019-237 & 2020-401)
Summary: UCLA researchers in the department of electrical and computer engineering have developed a device for synchronized biventricular pacing. Background: Many patients with impaired cardiac function suffer from ventricular desynchrony, a condition that involves a lack of synchronization between the contractions of the left and right ventricles...
Published: 9/19/2024   |   Inventor(s): Aydin Babakhani, Hongming Lyu, Medhi Razavi, Mathews John, Allison Post
Keywords(s): acute myocardial infarction, cardiac cycle, Cardiac failure, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular modeling, cardiovascular monitoring, cardiovascular prediction, cardiovascular therapeutic solution, medical device cardiac monitoring, non-invasive cardiac monitoring, tachycardia
Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems
Kcnab2 Conditional Knockout Mouse Model
­Advantages: A new Kcnab2 exon 4-floxed mice, suitable for experimental models to study muscle development, regeneration, and pathogenesis. Kcnab2 exon 4-floxed mice were successfully generated using CRISPR/Case9 technology. Allows for specific study of the Kcanb2 function on skeletal muscle (e.g. TA) without significant changes in the brain...
Published: 9/20/2024   |   Inventor(s): Srinivas Tipparaju
Keywords(s): Animal Models, Cardiological Diseases Treatment, Cardiovascular Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Cell & Tissue Engineering
Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)
Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...
Published: 6/24/2024   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyou-Arm Joung, Dino Di Carlo
Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays
A Constitutive-based Machine Learning Model for The Identification of Active Contraction Properties in the Ventricular Myocardium
­Advantages: The deep learning-based approach enables accurate forecasting of left ventricular active contractions, providing early indicators of potential cardiovascular diseases, allowing for timely intervention and improved patient outcomes. The technology utilizes clinical metrics and imaging data, avoiding invasive procedures, and reducing...
Published: 8/15/2023   |   Inventor(s): Igor Nobrega
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Machine Learning
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging
Self-Replicating Cell-Selective Therapy for Atherosclerotic Cardiovascular Disease
­Advantages: It utilizes a targeted approach by selectively expressing the therapeutic agent in vascular smooth muscle cells and infiltrating immune cells, it minimizes potential off-target effects and preserves the function of the endothelial cells. By combining two complementary mechanisms, the miRNA switch and siRNA technology, this research...
Published: 6/11/2024   |   Inventor(s): Isabella Hetherington
Keywords(s): Cardiovascular Diseases, Drug Delivery and Nanomedicine
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Targeting Alu RNA to treat atherosclerotic cardiovascular disease
Advantages Human Lungs & coronary arteries from COVID-19 patients showed increased expression of Alu RNA Alu RNA induces non-resolving inflammation in atherosclerosis Antisense Oligos targeting Alu RNA can reduce inflammation Summary Atherosclerotic cardiovascular diseases continue to be the leading cause of death worldwide. Viral infections,...
Published: 4/26/2024   |   Inventor(s): Hana Totary-Jain
Keywords(s): Cardiovascular Diseases, Inflammation
Category(s): Technology Classifications > Medical > Therapeutics
Intra-Cardiac Pulsatile Ventricular Assist Device
­Competitive Advantages Implanted via catheter and transapical techniques, both minimally invasive and safely established surgical methods. Includes multiple indentations to leave room for papillary muscles to function properly. Lower risk of complications such as GI bleeding and hemolysis compared to current solutions. Summary Our researchers...
Published: 2/23/2024   |   Inventor(s): Fadi Matar, Jonathan Ford, Summer Decker
Keywords(s): Cardiovascular Diseases, Medical Devices, Surgical Tools
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical
Bio Acoustic Signal Feature Extraction and Pattern Recognition Framework
Competitive Advantages Accurate abnormality classification Accurate sinus rhythm recognition Novel feature extraction and machine framework Quantitatively validated results Summary USF researchers have developed a machine learning framework to identify the patterns of cardiac sounds. The acoustic sounds are obtained from the body site and are...
Published: 5/30/2023   |   Inventor(s): Prashanth Chetlur Adithya, Shraddha Pandey, Ravi Sankar, Wilfrido Moreno
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases
Category(s): Technology Classifications > Software, Technology Classifications > Medical, Technology Classifications > Medical > Medical Diagnostics
Shift of Metabolic ATP Production and Cellular Oxygen Consumption
Competitive Advantages Increased endothelial cell anaerobic glycolysis Edema prevention Enhanced endothelial barrier function A potential treatment for many diseases Summary Our researchers have developed a method which utilizes agents that activate σ1. The activation of σ1 encourages the metabolic production of...
Published: 11/16/2023   |   Inventor(s): Jerome Breslin, Zeinab Motawe
Keywords(s): Cardiovascular Diseases, Diabetes, Inflammatory Diseases, Stroke Treatment, Therapeutics
Category(s): Technology Classifications > Medical
3D Printed Inner Ventricular Membrane for Cardiac Stroke Volume Simulation
Competitive Advantages Realistic simulation of a human heart Pulsatile flow pump with simulated systole and diastole 3D printed inner membrane Hydrodynamic driver for inflow & outflow Summary We have developed a 3D printed inner ventricular membrane model of the heart that is capable of a realistic depiction of the ventricular...
Published: 9/8/2022   |   Inventor(s): Fadi Matar, Jonathan Ford, Summer Decker
Keywords(s): 3D Printing, Cardiovascular Diseases, Medical Diagnostics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Medical Devices
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