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Search Results - monoclonal
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Title
ID
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High-Affinity Mouse
Monoclonal
Antibodies to GPC-3 for Liver Cancer Research
Abstract: The National Cancer Institute Laboratory of Molecular Biology seeks parties for collaborative research to co-develop and commercialize antibody drug/toxin conjugates as liver cancer therapy and diagnostics. There is great interest and value in developing more sensitive and efficient agents for earlier detection of hepatocellular cancer (HCC). ...
Published: 5/21/2024
|
Inventor(s):
Mitchell Ho
,
Yen Phung
,
Wei Gao
,
Yifan Zhang
Keywords(s):
ANTIBODY
,
GLYCOPROTEIN
,
Glypican-3
,
GPC3
,
HCC
,
hepatocellular carcinoma
,
liver
,
monoclonal
Category(s):
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
,
Application > Therapeutics
,
Collaboration Sought > Licensing
Human and Improved Murine
Monoclonal
Antibodies Against CD22
Abstract: CD22 is a common cell surface glycoprotein expressed in B-cells and present in B-cell lymphomas; e.g., hairy cell leukemia (HCL), non-Hodgkins lymphoma (NHL), chronic lymphoblastic leukemia (CLL), and other cancers. It is therefore a target for cancer immunotherapy. Conjugation of anti-CD22
monoclonal
antibodies with toxins or drugs has shown...
Published: 8/14/2024
|
Inventor(s):
Dimiter Dimitrov
,
Xiaodong Xiao
,
Ira Pastan
Keywords(s):
antibodies
,
ANTIGEN
,
B-CELL
,
B-Cell Lymphoma
,
Bcl
,
CANCER
,
CD22
,
Chronic Lymphoblastic Leukemia
,
CLL
,
Dimitrov
,
Hairy cell leukemia
,
HCL
,
Human
,
monoclonal
,
NHL
,
non-Hodgkins lymphoma
,
Oncology
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
A Rabbit Anti-pT1989 ATR
Monoclonal
Antibody for Use in Immunoassays
Abstract: Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is essential for regulating DNA damage checkpoints during the cell cycle. ATR, is phosphorylated at threonine 1989 site (T1989) in response to DNA damage and ATR activation leads to activation of downstream substrates, signaling cascades and cell cycle arrest. ATR is a potential...
Published: 4/8/2024
|
Inventor(s):
Thomas Pfister
,
Allison Marrero
,
Ralph Parchment
,
James Doroshow
,
Robert Kinders
Keywords(s):
ANTIBODY
,
assay
,
Ataxia telangiectasia mutated and Rad3-related kinase
,
CANCER
,
diagnostic
,
DNA checkpoint
,
monoclonal
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Diagnostics
Monoclonal
Antibody Fragments for Targeting Therapeutics to Growth Plate Cartilage
Abstract: A child's growth is dependent on the proper functioning of the growth plate, a specialized cartilage structure located at the ends of long bones and within the vertebrae. The primary function of the growth plate is to generate new cartilage, which is then converted into bone tissue and results in the lengthening of bones. Failure of the growth...
Published: 4/8/2024
|
Inventor(s):
Jeffrey Baron
,
Sao Fong (Crystal) Cheung
,
Chun Lui
,
Dimiter Dimitrov
,
Zhongyu Zhu
Keywords(s):
Anti-mantrilin-3 Antibody
,
ARTHRITIS
,
Baron
,
Cartilage
,
Dimitrov
,
Eunice Kennedy Shriver National Institute on Child Health an
,
Growth plate
,
Human Growth Hormone
,
monoclonal
,
NICHD
,
OSTEOARTHRITIS
,
Short Stature
,
Skeletal Dysplasia
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics
Monoclonal
Antibody Against Human Alpha-5 Integrin that Does Not Disrupt Adhesive Function
This technology includes a rat
monoclonal
antibody termed mAb11 was generated against the human alpha-5 integrin subunit and can provide immunological characterizations without disrupting integrin adhesive function. It permits characterization of its localization even if the receptor is bound to its fibronectin ligand. The antibody is commercially available...
Published: 12/26/2024
|
Inventor(s):
Steven Akiyama
,
Susan Yamada
,
Kenneth Yamada
Keywords(s):
Against
,
Alpha-5
,
ANTIBODY
,
DISRUPT
,
DOES
,
FUNCTION
,
Human
,
INTEGRIN
,
monoclonal
,
That
,
WIXXXX
,
XAXXXX
Category(s):
Application > Research Materials
,
ResearchProducts > Antibodies
,
TherapeuticArea > Immunology
Monoclonal
Antibodies To Prevent or Treat SARS-CoV-2 Infection
The ongoing COVID-19 pandemic, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an immense public health, social, and economic burden. Variants of concern continue to emerge that have increased transmissibility, pathogenicity, or both and that reduce the effectiveness of current therapeutics and vaccines. Thus, there is...
Published: 10/28/2024
|
Inventor(s):
Patrizia Farci
,
Kamille West
,
Peng Zhang
,
Paolo Lusso
,
Zhaochun Chen
Keywords(s):
antibodies
,
Cure
,
Disease
,
monoclonal
,
Prevent
,
SARS-CoV-2
Category(s):
Collaboration Sought > Collaboration
Human
Monoclonal
and Bispecific Antibodies Targeting SARS-CoV-2 Coronavirus
SARS-CoV-2 is a virus of the Coronavirus family that has emerged as a major public health concern. The first cases of SARS-CoV-2 were reported in China and rapidly spread worldwide leading to a global pandemic. The highest morbidity and mortality have been reported in the elderly and immunocompromised. Antibody therapeutics have great importance for...
Published: 10/28/2024
|
Inventor(s):
Peter Crompton
,
Hyeseon Cho
,
Kristina Gonzales-Wartz
,
Mary Peter
,
Joshua Tan
Keywords(s):
antibodies
,
Human
,
monoclonal
,
SARS-CoV-2
,
Targeting
Category(s):
Collaboration Sought > Collaboration
Polyclonal and
Monoclonal
Antibodies to Human Eosinophil Major Basic Protein, Eosinophil Peroxidase, Eosinophil Cationic Protein, and Eosinophil-Derived Neurotoxin
Reagents particularly useful in configuring multiplex assays for simultaneous measurement and quantification of multiple eosinophil granule proteins and for immunohistochemistry. Ultimately these reagents may be used as diagnostics for many eosinophil-mediated disorders.
Published: 10/28/2024
|
Inventor(s):
Richard Davey
,
Thomas Nutman
Keywords(s):
antibodies
,
BASIC
,
CATIONIC
,
EOSINOPHIL
,
Eosinophil-Derived
,
Eosionophil
,
Human
,
Listed LPM Fenn as of 4/15/2015
,
MAJOR
,
monoclonal
,
Neurotoxin
,
PEROXIDASE
,
polyclonal
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
Protein
,
RM
,
WIXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
Monoclonal
Antibodies for Specific Detection of Dengue Virus Sub-type 4 in Human Serum
Dengue Virus (DENV) non-structural protein 1 (NS1) is secreted in blood during the acute phase of viremic DENV infection. While there are commercially available ELISA assays for DENV NS1 detection, these tests have limited sensitivity (50-70%), do not determine the serotype of the infecting DENV, do not detect all four serotypes equally, or are less...
Published: 10/28/2024
|
Inventor(s):
Tesfaye Taye
,
Elizabeth Hunsperger
Keywords(s):
1
,
4
,
antibodies
,
DENGUE
,
DENV
,
monoclonal
,
NCEZID
,
NCEZID-DVBD
,
Non-structural
,
NS1
,
Protein
,
Serotype
,
Specific
,
virus
,
VLXXXX
,
WBXXXX
,
WHXXXX
,
WIXXXX
,
XAXXXX
,
XEXXXX
,
YBXXXX
,
YDXXXX
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
TherapeuticArea > Immunology
,
Application > Research Materials
,
ResearchProducts > Antibodies
,
Application > Diagnostics
Zika Virus NS1 Protein
Monoclonal
Antibodies for Research, Development, and Novel Diagnostics
Zika virus is a flavivirus that is spread by the bite of infected Aedes mosquitoes. The current outbreak and swift dissemination/spread of Zika virus (ZIKV) and its linkage to birth defects and neurological syndromes has prompted the development of novel diagnostic tests. Because ZIKV is serologically similar to other flaviviruses such as dengue virus...
Published: 10/28/2024
|
Inventor(s):
Dennis Bagarozzi
,
Jason Goldstein
Keywords(s):
antibodies
,
Development
,
Diagnostics
,
monoclonal
,
NCEZID
,
NCEZID-DSR
,
Novel
,
virus
,
VLXXXX
,
WBXXXX
,
WIXXXX
,
XAXXXX
,
YBXXXX
,
Zika
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Diagnostics
,
Application > Research Materials
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Immunology
,
ResearchProducts > Antibodies
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