Search Results - non-invasive

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Needle Clamp With Rolling Sphere (Case No. 2024-211)
Summary: UCLA researchers from the Department of Radiology have developed a novel needle-holding clamp for use during minimally invasive procedures. Background: Minimally invasive procedures are now widely used for diagnosing and treating subcutaneous and deep tissue targets. These procedures use percutaneous needle insertions rather than large incisions...
Published: 11/5/2024   |   Inventor(s): David Lu
Keywords(s): femtech medical device, Invasiveness Of Surgical Procedures, Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, Microneedle array, minimally invasive device, minimally invasive procedures, needle guidance, needle holder, noninvasive, non-invasive, non-invasive drug monitoring, non-invasive imaging, non-invasive monitoring, Smart medical device, tissue targeting accuracy, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Surgical Tools
Salivary Exosome (NSEV) Analysis to Elucidate Intercellular Signaling Events that Precede Pilot Fatigue (UCLA Case No. 2021-172)
Researchers at UCLA’s Department of Neurology and Drug Discovery Lab have identified a novel set of biomarkers that change based on levels of Cognitive Fatigue (CF). These biomarkers can be used to non-invasively predict and assess levels of cognitive fatigue. BACKGROUND: Cognitive fatigue (CF) is an important factor in the efficiency and safety...
Published: 7/31/2024   |   Inventor(s): Bruce Teter, Samuel Whitaker Johnson-Cohn, Varghese John
Keywords(s): biomarkers, cognitive fatigue, exosome, noninvasive, non-invasive
Category(s): Diagnostic Markers > Targets And Assays
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
2022-296 Utility of a High Resolution, Infrared Thermal-Imaging as a Novel Intraoperative Augmented Reality Device
Summary: UCLA Resident Physician, Dr. Kyle Klingbeil, MD., in the Molecular, Cellular & Integrative Physiology (MCIP) program and Karie Villanueva, MD., have developed a novel image-guided surgery (IGS) modality that utilizes non-invasive, real-time high-resolution imaging techniques to better guide surgeons during operations. Background: Intraoperative...
Published: 8/21/2023   |   Inventor(s): Kyle Klingbeil, Karie Villanueva
Keywords(s): Augmented Reality, augmented reality (AR), Endoscopes, endoscopic devices, Endoscopy, High-resolution, Image Resolution, image-guided surgery, Infrared, infrared thermal imaging, intraoperative device, laparoscopic devices, non-invasive, perforator flap, real-time, remote collaboration, robot-assisted surgery, Robotic Surgery, Robotics, Surgery, surgical oncology, telementoring, thermal imaging, transplant surgery
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Electrical, Electrical > Imaging, Electrical > Sensors, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems
DNA Methylation Based Non-invasive Blood Diagnostic Assay for Precision Cancer Detection and Classification
This technology includes a panel of 46 genomic loci of DNA methylation (represented by CpG dinucleotides on different chromosomes) with application in blood-based cancer screening. The markers robustly distinguish tumor from normal samples using 8 loci and classify 13 different tumor types. Using 39 loci, inventors were able to discriminate between...
Published: 10/28/2024   |   Inventor(s): Gennady Margolin, Laura Elnitski
Keywords(s): assay, Based, Blood, CANCER, CLASSIFICATION, Detection, diagnostic, DNA, Humans, Methylation, NON-INVASIVE, PRECISION, VCXXXX, WBXXXX, WIXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
Non-invasive Isotopic Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)
Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. The most common cause of isolated MMA is genetic deficiency of the enzyme methylmalonyl-coA mutase (MUT), which, unfortunately for the affected patients, is also the most clinically severe. NHGRI scientist have invented a series...
Published: 10/28/2024   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Acidemia, Biomarkers, Directed, ISOTOPIC, liver, Methymalonic, MMA, NON-INVASIVE, PREDICT, RESPONSE, That, THERAPY, VPXXXX, WFXXXX, WIXXXX, XCXXXX
Category(s): Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology
Non-invasive Method for Ebola Virus Infection Detection in Great Apes and Other Wildlife Hosts
Ebola virus surveillance in wildlife vectors of infection transmission to humans.
Published: 10/28/2024   |   Inventor(s): Nancy Sullivan
Keywords(s): ACXXXX, Apes, Detection, Ebola, HOSTS, HostsNon-invasive, Humans, Infection, Method, NON-INVASIVE, Nucleoprotien, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, RM, Surveillance, TRANSMISSION, vectors, virus, VLXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials
FUNCTIONAL NEAR INFRARED SPECTROCOPY BASED BRAIN COMPUTER INTERFACE
PAGE TITLEOverviewPAGE SUMMARY Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down-regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over...
Published: 7/12/2024   |   Inventor(s): Hasan Ayaz, Banu Onaral, Patricia (trish) Shewokis, Scott Bunce
Keywords(s): NIR - near infrared, Non-invasive
Category(s): Medical Devices & Diagnostics, Computing, Software, Analytics & Information Technology, Medical Devices & Diagnostics > MDD: Functional Near Infrared Imaging, Computing, Software, Analytics & Information Technology > Computing: Signal Processing
Deception detection and query methodology for determining deception via neuroimaging
PAGE TITLEOverviewPAGE SUMMARYFunctional near-infrared (fNIR) neuroimaging is used to assess credibility, detect deception, and implement a query methodology for determining deception via neuroimaging. Oxygenation levels of portions of the brain are imaged via fNIR spectroscopy and utilized to determine if the subject is telling a lie or a truth. In...
Published: 7/11/2024   |   Inventor(s): Kurtulus Izzetoglu, Meltem Izzetoglu, Kambiz Pourrezaei, Banu Onaral, Ajit Devaraj, Scott Bunce
Keywords(s): Military, NIR - near infrared, Non-invasive
Category(s): Medical Devices & Diagnostics, Hardware, Circuits & Sensors, Computing, Software, Analytics & Information Technology, Medical Devices & Diagnostics > MDD: Functional Near Infrared Imaging, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Computing, Software, Analytics & Information Technology > Computing: Signal Processing