Search Results - non-invasive

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Salivary Exosome (NSEV) Analysis to Elucidate Intercellular Signaling Events that Precede Pilot Fatigue (UCLA Case No. 2021-172)
Researchers at UCLA’s Department of Neurology and Drug Discovery Lab have identified a novel set of biomarkers that change based on levels of Cognitive Fatigue (CF). These biomarkers can be used to non-invasively predict and assess levels of cognitive fatigue. BACKGROUND: Cognitive fatigue (CF) is an important factor in the efficiency and safety...
Published: 7/31/2024   |   Inventor(s): Bruce Teter, Samuel Whitaker Johnson-Cohn, Varghese John
Keywords(s): biomarkers, cognitive fatigue, exosome, noninvasive, non-invasive
Category(s): Diagnostic Markers > Targets And Assays
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
2022-296 Utility of a High Resolution, Infrared Thermal-Imaging as a Novel Intraoperative Augmented Reality Device
Summary: UCLA Resident Physician, Dr. Kyle Klingbeil, MD., in the Molecular, Cellular & Integrative Physiology (MCIP) program and Karie Villanueva, MD., have developed a novel image-guided surgery (IGS) modality that utilizes non-invasive, real-time high-resolution imaging techniques to better guide surgeons during operations. Background: Intraoperative...
Published: 8/21/2023   |   Inventor(s): Kyle Klingbeil, Karie Villanueva
Keywords(s): Augmented Reality, augmented reality (AR), Endoscopes, endoscopic devices, Endoscopy, High-resolution, Image Resolution, image-guided surgery, Infrared, infrared thermal imaging, intraoperative device, laparoscopic devices, non-invasive, perforator flap, real-time, remote collaboration, robot-assisted surgery, Robotic Surgery, Robotics, Surgery, surgical oncology, telementoring, thermal imaging, transplant surgery
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Electrical, Electrical > Imaging, Electrical > Sensors, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems
DNA Methylation Based Non-invasive Blood Diagnostic Assay for Precision Cancer Detection and Classification
This technology includes a panel of 46 genomic loci of DNA methylation (represented by CpG dinucleotides on different chromosomes) with application in blood-based cancer screening. The markers robustly distinguish tumor from normal samples using 8 loci and classify 13 different tumor types. Using 39 loci, inventors were able to discriminate between...
Published: 7/25/2024   |   Inventor(s): Gennady Margolin, Laura Elnitski
Keywords(s): assay, Based, Blood, CANCER, CLASSIFICATION, Detection, diagnostic, DNA, Humans, Methylation, NON-INVASIVE, PRECISION, VCXXXX, WBXXXX, WIXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
Non-invasive Isotopic Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)
Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. The most common cause of isolated MMA is genetic deficiency of the enzyme methylmalonyl-coA mutase (MUT), which, unfortunately for the affected patients, is also the most clinically severe. NHGRI scientist have invented a series...
Published: 7/25/2024   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Acidemia, Biomarkers, Directed, ISOTOPIC, liver, Methymalonic, MMA, NON-INVASIVE, PREDICT, RESPONSE, That, THERAPY, VPXXXX, WFXXXX, WIXXXX, XCXXXX
Category(s): Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology
Non-invasive Method for Ebola Virus Infection Detection in Great Apes and Other Wildlife Hosts
Ebola virus surveillance in wildlife vectors of infection transmission to humans.
Published: 7/25/2024   |   Inventor(s): Nancy Sullivan
Keywords(s): ACXXXX, Apes, Detection, Ebola, HOSTS, HostsNon-invasive, Humans, Infection, Method, NON-INVASIVE, Nucleoprotien, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, RM, Surveillance, TRANSMISSION, vectors, virus, VLXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials
FUNCTIONAL NEAR INFRARED SPECTROCOPY BASED BRAIN COMPUTER INTERFACE
PAGE TITLEOverviewPAGE SUMMARY Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down-regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over...
Published: 7/12/2024   |   Inventor(s): Hasan Ayaz, Banu Onaral, Patricia (trish) Shewokis, Scott Bunce
Keywords(s): NIR - near infrared, Non-invasive
Category(s): Medical Devices & Diagnostics, Computing, Software, Analytics & Information Technology, Medical Devices & Diagnostics > MDD: Functional Near Infrared Imaging, Computing, Software, Analytics & Information Technology > Computing: Signal Processing
Deception detection and query methodology for determining deception via neuroimaging
PAGE TITLEOverviewPAGE SUMMARYFunctional near-infrared (fNIR) neuroimaging is used to assess credibility, detect deception, and implement a query methodology for determining deception via neuroimaging. Oxygenation levels of portions of the brain are imaged via fNIR spectroscopy and utilized to determine if the subject is telling a lie or a truth. In...
Published: 7/11/2024   |   Inventor(s): Kurtulus Izzetoglu, Meltem Izzetoglu, Kambiz Pourrezaei, Banu Onaral, Ajit Devaraj, Scott Bunce
Keywords(s): Military, NIR - near infrared, Non-invasive
Category(s): Medical Devices & Diagnostics, Hardware, Circuits & Sensors, Computing, Software, Analytics & Information Technology, Medical Devices & Diagnostics > MDD: Functional Near Infrared Imaging, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Computing, Software, Analytics & Information Technology > Computing: Signal Processing