Search Results - gene+expression

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Molecular Classification of Primary Mediastinal Large B Cell Lymphoma Using Formalin-Fixed, Paraffin-Embedded Tissue Specimens
Abstract: Primary mediastinal B-cell lymphoma (PMBCL) is an aggressive type of non-Hodgkin lymphoma that mostly occurs in people between the ages of 30-40. It accounts for 5-7% of all aggressive lymphomas. The diagnosis of PMBCL is challenging as the histological features of PMBCL overlap with diffuse large B-cell lymphoma (DLBCL), another most common...
Published: 4/8/2024   |   Inventor(s): Louis Staudt, Lisa Rimsza, David Scott, George Wright, Anja Mottok, Christian Steid, Elaine Jaffe, Randy Gascoyne, Elias Guerri, Elias Guerri, Elias Guerri, Andreas Rosenwald, Kai Fu, Timothy Greiner, Erlend Smeland, Jan Delabie, Rita Braziel, Wing Chan, Joo Song, Dennis Weisenburger, German Ott, James Cook
Keywords(s): assay, Diffuse Large B Cell Lymphoma, DLBCL, FFPE, Formalin-fixed, GENE EXPRESSION, paraffin-embedded biopsies, PMBCL, Primary Mediastinal Large B Cell Lymphoma, Staudt
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics
Single Cell In-Situ Extraction with Intact 3D Morphology from Formalin Fixed Paraffin Embedded (FFPE) Tissues
FFPE is a well-established and widely used method for preservation and histological analysis of tissue samples. DNA/RNA/and Proteins can be extracted from FFPE samples, but generally lack single cell resolution and completely lack 3D spatial resolution. Enabling 3D resolution allows the correlation of morphology to information like gene expression,...
Published: 4/25/2023   |   Inventor(s): David Richardson, Thai Tran, Dmitry Derkach, Colleen Ziegler
Keywords(s): Bioanalysis, Biological Cell Manipulation, Bio-Technology, Cancer, Device, Diagnostics, Gene Expression, Genomics, Proteomics, In situ, Molecular Diagnostics, Single-cell analysis
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
TUNABLE RNA INTERFERENCE VIA NUCLEOTIDE MISMATCH DESIGN
TUNABLE RNA INTERFERENCE VIA NUCLEOTIDE MISMATCH DESIGN Researchers at Stanford, the University of Massachusetts and the Chan Zuckerberg Biohub have developed methods to increase or decrease RNA interference target cleavage rates. Harnessing the power of RNA interference (RNAi), the biological process of RNA-guided and sequence-specific gene expression...
Published: 10/26/2024   |   Inventor(s): William Greenleaf, Phillip Zamore, Winston Becker, Benjamin Ober-Reynolds, Karina Jouravleva, Samson Jolly
Keywords(s): Gene Expression, miRNA, Nucleotide, RNAi, siRNA
Category(s): Technology Classifications > Biology
Biomarkers for Irritable Bowel Syndrome (IBS)
Approximately 9% of the general population will report the onset of Irritable Bowel Syndrome (IBS) over a one year period. Unfortunately, at present, there is no standard and reliable diagnostic test for IBS. IBS is currently diagnosed using symptomatic criteria, but because symptoms of IBS can overlap with other GI diseases, there is considerable uncertainty...
Published: 2/23/2023   |   Inventor(s): Todd Sandrin, Peter Jurutka
Keywords(s): Biosignature, Bio-Technology, Gene Expression, Genomics, Proteomics, MicroArray, Molecular Diagnostics
Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors
Manipulating mRNA Decay Pathway to Regulate Gene Expression
Brief Description: The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome....
Published: 10/28/2024   |   Inventor(s): Lynne Maquat, Chenguang Gong
Keywords(s): Gene Expression, Gene Silencing, RNA
Category(s): Therapeutic, Research Tools
Method for Classification of Cells Based on Gene Expression
Researchers at the University of Arizona have developed methodology to characterize global gene expression within a single cell nucleus. It is envisioned that this technology will be applicable to the diagnosis of disease states in tissue or organ biopsies. It will provide signature expression patterns of normal and diseased tissue. A comprehensive...
Published: 4/3/2023   |   Inventor(s): David Galbraith, Georgina Lambert, Roger Lasken, Rashel Grindberg
Keywords(s): cancer, diagnosis, gene expression, nucleus, prognosis
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diagnostics