Search Results - myotonic+dystrophy

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Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 3/12/2024   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Synthetic Proteins for Muscular Dystrophy Treatment
Displace or Replace Mutant MBNL Proteins that Cause Repeat Expansion DiseasesThis synthetic muscleblind-like (MBNL) protein can displace or replace the mutations that cause repeat expansion diseases, such as myotonic muscular dystrophy and spinocerebellar ataxia. Repeat expansion mutations cause more than 20 types of neurological diseases, including...
Published: 6/27/2021   |   Inventor(s): John Berglund, Melissa Hale
Keywords(s): Myotonic Dystrophy, Protein, synthetic gene
Category(s): Technology Classifications > Human Health Care > Therapeutics
Monoclonal Antibody against CUGBP2/ETR-3 Proteins
Recognizes Both Human and Mouse CUGBP2/ETR-3 Proteins but Does Not Bind to Other CELF Family MembersCUGBP2/ETR-3 is a member of the CELF family of pre-mRNA alternative splicing factors which play an important role in the appearance of specific protein isoforms during postnatal development. The CELF family has also been implicated in the neuromuscular...
Published: 7/12/2022   |   Inventor(s): Maurice Swanson
Keywords(s): Antibody, COX2, CUGBP2, Monoclonals, Myotonic Dystrophy, RNA Splicing, RNA Turnover
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
Dmpk CTG480 Knockin Myoblasts as a Cell Model for Myotonic Dystrophy Type 1
Myoblasts Isolated from a Myotonic Dystrophy Type 1 Mouse Model Serve as a Platform for Drug Development and ResearchThese Dmpk CTG480 knockin mouse myoblasts are isolated from Dmpk CTG480 knockin mice for use as a cell model for myotonic dystrophy type 1. Myotonic dystrophy type 1 (DM1) is an inherited, multi-system disorder, affecting 1 in 8500 individuals...
Published: 6/27/2021   |   Inventor(s): Maurice Swanson, Curtis Nutter
Keywords(s): DM1, microsatellites, Mouse Model, Myotonic Dystrophy
Category(s): Technology Classifications > Research Tools > Biological Materials
Dmpk CTG480 Knock-in Mouse Model for Myotonic Dystrophy Type 1
Myotonic Dystrophy Type 1 Mouse Model as a Tool for Drug Development and ResearchMyotonic dystrophy type 1 (DM1) is an inherited, multi-system disorder, affecting 1 in 8,500 individuals worldwide. However, no effective therapies are currently available for this disease. Clinical symptoms may vary from almost asymptomatic to progressive skeletal muscle...
Published: 7/18/2023   |   Inventor(s): Ruan Oliveira, Maurice Swanson
Keywords(s): DM1, microsatellites, Mouse Model, Myotonic Dystrophy
Category(s): Technology Classifications > Research Tools > Biological Materials