NU 2021-153
INVENTORS Arun Sharma* Matthew Bury Natalie Fuller
SHORT DESCRIPTION A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue
ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of organ function due to injury or disease. The existing standard of care for patients with damaged or impaired bladder function, as occurs in the case of spina bifida, interstitial cystitis, or bladder cancer, is urinary diversion or bladder enterocystoplasty. These existing strategies, however, typically lead to significant short- and long-term complications. Hence, there is a pressing need for effective bladder repair strategies and corresponding therapeutics. Following bladder augmentation operations for cystectomy, the small molecule improved the outcomes of holistic bladder repair through improved peripheral nerve reinnervation and revasculaturation. The drug could be delivered through a host material, that has previously been validated towards bladder repair applications. Importantly, the small molecule promoted healthier tissue compositioin with the regenerated tissue consisting of an impressive collagen to muscle ratio of about 1:1.
APPLICATIONS
ADVANTAGES
IP STATUS Filed Provisional Patent Application 63/268,267