Search Results - patrick+harran

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Methods To Generate Constrained Fluorinated Macrocycles (UCLA Case No. 2023-139)
UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel method to generate fluorinated polycycles, which may be used for downstream drug discovery and development. BACKGROUND: A significant amount of research in the field of organic chemistry centers around generating increasingly complex molecules that cyclize, forming...
Published: 5/30/2025   |   Inventor(s): Patrick Harran
Keywords(s): Drug Discovery
Category(s): Chemical > Synthesis, Chemical > Catalysts
2014-387 Small Molecule Antagonists of the Pro-Survival Protein MCL-1 (POC 2016)
Small Molecule Antagonists Of The Pro-Survival Protein Mcl-1SUMMARYUCLA Researchers have discovered novel inhibitors to signaling proteins involved in the regulation of apoptosis. MCL-1, which is known to be overexpressed in many cancers, is believed to be upregulated in cancers to prevent the apoptosis pathway.The researchers have developed novel small...
Published: 3/6/2025   |   Inventor(s): Patrick Harran, Gordon Shore, James Frederich, Mai Nguyen
Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)