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Search Results - wanling+xuan
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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 11/18/2025
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Inventor(s):
Feng Yan
,
Lin Li
Keywords(s):
Category(s):
Semiconductors, Materials & Processes
,
Microelectronics
,
Physical Science
,
Semiconductor Devices
,
Manufacturing/Construction/Mechanical
A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 10/14/2025
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Inventor(s):
Wanling Xuan
,
Srinivas Tipparaju
Keywords(s):
Cardiological Diseases Treatment
,
Cardiovascular Diseases
,
Drug Discovery
Category(s):
zzCardiology
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Therapeutics
Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 9/11/2025
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Inventor(s):
Wanling Xuan
Keywords(s):
Drug Discovery
,
Medical Pharmaceuticals
,
Therapeutics
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
Targeting Cellular Senescence by PD-L1 Binding Peptide Engineered Extracellular Vesicles
Advantages: Engineered extracellular vesicles (EVs) by surface modification with PD-L1 binding peptide and PEGylation to target senescent VSMCs. Promising novel interventions for age-related and vascular diseases. Efficacy: Proven uptake of modified EVs in the aorta of old mice and senescent VSMCs. Summary: Targeting senescent cells, particularly...
Published: 10/14/2025
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Inventor(s):
Wanling Xuan
,
Srinivas Tipparaju
,
Vijaykumar Sutariya
Keywords(s):
Drug Delivery and Nanomedicine
,
Genetics
,
Peptides
Category(s):
Technology Classifications > Medical > Medical Nanotechnology
,
Technology Classifications > Medical > Biotechnology
Resurfaced Stabilized Core 3 (RSC3) Protein, Derived Proteins, and DNA Encoding These Proteins: RSC3, RSC3 delta371I, RSC3 delta371I/P363N, RSC3 G367R
Details for these materials may be found in the NIH AIDS Reagent Program Catalog – RSC3 (Catalog# 12042): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=214 RSC3 delta371I (Catalog# 12043): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=146 RSC3 delta371I/P363N (Catalog# 12362): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=145 RSC3...
Published: 8/13/2025
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Inventor(s):
Tongqing Zhou
,
Gary Nabel
,
Zhi-yong Yang
,
Ling Xu
,
Peter Kwong
Keywords(s):
3
,
Core
,
DERIVED
,
DNA
,
Encoding
,
Protein
,
proteins
,
Resurfaced
,
RM
,
RSC3
,
Stabilized
,
THESE
,
WIXXXX
Category(s):
Collaboration Sought > Licensing
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Collaboration Sought > Materials Available
,
Application > Research Materials
Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 1/9/2026
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Inventor(s):
Michael Keidar
,
Li Lin
,
Vikas Soni
,
Xiaoliang Yao
,
Dayun Yan
,
Jonathan Sherman
Keywords(s):
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Medical Devices > Surgical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 1/9/2026
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Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 1/9/2026
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Inventor(s):
Michael Keidar
,
Zhitong Chen
,
Xiaoqian Cheng
,
Li Lin
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics
Functional Nanoglues for Stable Metal Single-Atom and Cluster Catalysts
Background Recent advances in catalysis by single-atom catalysts (SACs) and cluster catalysts have highlighted the unique catalytic properties of highly dispersed metal species. The use of single metal atoms or small clusters for catalysis is not only cost-effective but also significantly enhances the selectivity of a targeted reaction, resulting in...
Published: 2/13/2025
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Inventor(s):
Jingyue Liu
,
Xu Li
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Environmental
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Environmental Remediation/Wastewater Treatment
,
Physical Science
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