Search Results - antibiotics

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Combining Aminoglycoside Antibiotics and PKZ18 Analogs
Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance. Background: To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...
Published: 1/24/2024   |   Inventor(s): Ville Väre, Ryan Schneider
Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
Halogenated Phenazines: Antibacterial Compounds that Prevent and Eradicate Microbial Biofilms
Antibiotic Effectively Disinfects and Eradicates Bacterial Pathogens Where Biofilm Is PresentThis series of antibacterial agents, known as the halogenated phenazines, are able to eradicate free-floating (planktonic) bacteria in addition to persistent, surface-attached bacterial biofilms against gram positive organisms such as methicillin-resistant Staphylococcus...
Published: 6/27/2021   |   Inventor(s): Shouguang Jin, Robert Huigens
Keywords(s): 2.4-debromo-1-hydroxyphenazine, 2.4-dibromo-1-acetoxyphenazine, 2-bromo-1-hydroxyphenazine, Antibacterial, antibactrial agent, Antibiotics, bromophenazine antibacterial, Disinfectants
Category(s): Technology Classifications > Human Health Care > Therapeutics
Antibacterial Peptides, Synbodies, and Methods of Discovery
Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....
Published: 2/23/2023   |   Inventor(s): Chris Diehnelt, Stephen Johnston
Keywords(s): Antibiotic Resistance Treatments, Antibiotics, Anti-Infectives, Infectious Disease, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Vaccines/Antimicrobials, Pharmaceuticals, Proteomic Assays/Reagents/Tools
Antibacterial Peptides, Synbodies, and Methods of Discovery
Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....
Published: 2/23/2023   |   Inventor(s): Chris Diehnelt, Stephen Johnston, Pamela Hall
Keywords(s): Antibiotic Resistance Treatments, Antibiotic Resistant Bacteria, Antibiotics, Anti-Infectives, Drug Discovery, Infectious Disease, Peptides, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Pharmaceuticals, Vaccines/Antimicrobials
Antibacterial Adjuvants for Pseudomonas Aeruginosa
Antibacterial Adjuvants for Reduced Cationic Antimicrobial Peptide Dosing and Combination TherapyPrinceton Docket # 20-3616-1 Researchers in the Department of Chemistry at Princeton University and the Department of Chemistry at San Jose State University have discovered compounds which increase the susceptibility of both CAP-resistant as well...
Published: 2/15/2023   |   Inventor(s): Laura Conrad, Martin Semmelhack, Zinan Zhang, Minh Tran, Lauren Blankenship
Keywords(s): antibiotics
Category(s): Biotechnology/Pharmaceuticals
Novel Aconitase: Targeting Phenotypic Adaptation for Antimicrobial Development
Worldwide, bacterial pathogens pose an alarming public health threat due to their resistance to current antimicrobial drugs. While antibiotics have been widely used to prevent bacterial infections over the last 50-60 years, all major bacterial pathogens now are showing resistance to currently prescribed antibiotics worldwide. Increasing drug resistance...
Published: 4/26/2019   |   Inventor(s): Mehmet Candas, Lee Bulla
Keywords(s): Antibiotics, Biomarkers, Life Sciences, Medical, Molecular Biology, Therapeutics
Category(s): Healthcare, Research Tools
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Published: 6/18/2024   |   Inventor(s): Steven Sucheck, Donald Ronning, Sandeep Thanna, Alexander Landgraf
Keywords(s): Antibiotics, Anti-inflammatory, Antioxidant, Bipolar, Cancer, Cytoprotective, Hearing, Neurodegenerative, Reperfusion, Stroke
Category(s): Inflammation & Immunity
Peptide Inhibitors of Gonorrhoeae
Technology Description Antigonococcal peptide inhibitors of Neisseria gonorrhoeae that act against a non-conventional new target, nitrite reductase AniA, that is necessary for N. gonorrhoeae anaerobic respiration and biofilm formation. The anaerobic life style is an important state during disease and favored in biofilms, which form in cervical gonococcal...
Published: 12/23/2021   |   Inventor(s): Aleksandra Sikora, Konstantin Korotkov
Keywords(s): Antibiotics, Antimicrobial, Drug, Drug Development, Gonorrhea, Inhibitor, Microbiology, Peptide, Therapeutic
Category(s): Therapeutics, Vaccines
Antibiotic Susceptibility Testing
Antibiotic-resistant bacterial infections cost billions of dollars to the US in healthcare and result in 2 million hospitalizations and 23,000 deaths. Clinical treatment of bacterial infections, especially in acute cases of sepsis, requires multiple steps, including antibiotic susceptibility tests (AST). Current AST techniques are slow and limited to...
Published: 2/23/2023   |   Inventor(s): Nongjian (nj) Tao, Karan Syal
Keywords(s): Antibiotic Resistant Bacteria, Antibiotics, Antibodies, Antibody Therapeutics, Anti-Infectives
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Medical Diagnostics/Sensors
Pactamycin Analogs Having Antibacterial, Antitumor, and Antimalarial Activity
Background The global emergence of multi-drug resistant bacterial infections has resulted in enormous costs and has become a major threat to public health. About seventy percent of nosocomial infections are resistant to at least one commonly use antibiotic. Pactamycin is a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum....
Published: 6/17/2024   |   Inventor(s): Taifo Mahmud, Takuya Ito, Niran Roongsawang, Norifumi Shirasaka, Patricia Flatt
Keywords(s): Antibiotics, antiviral, Cancer, Malaria
Category(s): Therapeutics
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