Search Results - antibodies

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Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)
UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...
Published: 5/8/2024   |   Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova
Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan
Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease
Human and Improved Murine Monoclonal Antibodies Against CD22
Abstract: CD22 is a common cell surface glycoprotein expressed in B-cells and present in B-cell lymphomas; e.g., hairy cell leukemia (HCL), non-Hodgkins lymphoma (NHL), chronic lymphoblastic leukemia (CLL), and other cancers. It is therefore a target for cancer immunotherapy. Conjugation of anti-CD22 monoclonal antibodies with toxins or drugs has shown...
Published: 8/14/2024   |   Inventor(s): Dimiter Dimitrov, Xiaodong Xiao, Ira Pastan
Keywords(s): antibodies, ANTIGEN, B-CELL, B-Cell Lymphoma, Bcl, CANCER, CD22, Chronic Lymphoblastic Leukemia, CLL, Dimitrov, Hairy cell leukemia, HCL, Human, monoclonal, NHL, non-Hodgkins lymphoma, Oncology
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Nanobodies Neutralizing Lassa Virus
Abstract: Lassa Hemorrhagic Fever (LHF) is a serious disease caused by infection with Lassa virus (LASV) – highly prevalent in West Africa and spreading globally. LASV is associated with high morbidity and mortality rates, annually infecting 100,000 to 300,000 individuals and causing 5,000 deaths. Developing prophylactics and treatment for LASV is difficult...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Peter Kwong, Zhijian Duan, Yaping Sun, Sao Cheung, Jason Gorman
Keywords(s): antibodies, diagnostic, HO, LASSA, Lassa Hemorrhagic Fever, LHF, Nanobodies, Neutralizing, virus
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease
Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various antibody classes present in saliva. Background: Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 4/3/2024   |   Inventor(s): Adam Waickman, Stephen Thomas, Frank Middleton
Keywords(s): antibodies, antibody, infectious diseases, saliva, Technologies, viral immunology
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
A Rapid, High Content, Reagent Sparing, Fluorescent Plasmonic Assay Platform for Multiplexed Serum Antibody Detection in Lyme Disease and COVID-19
A protein microarray, in the form of a compact biochip, that can be analyzed with high sensitivity using GC-FP technology. Background: Some infectious diseases are easy to diagnose, but others are much more difficult. One example is Lyme disease (B. burgdorferi), which is caused by a slow-growing organism that takes many weeks to detect. Current...
Published: 9/20/2024   |   Inventor(s): Nathaniel Cady
Keywords(s): antibodies, assays, COVID-19, nanobioscience, nanobiotechnology, screens and assays, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Screens and Assays, Campus > SUNY Polytechnic Institute
Antibody Against Inositol 1,4,5-Trisphosphate Receptor Type 2 (anti-IP3R antibody)
Antibody against the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 Background: The inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca²⁺. Furthermore,...
Published: 1/3/2024   |   Inventor(s): Richard Wojcikiewicz
Keywords(s): antibodies, antibody
Category(s): Technology Classifications > Antibodies, Campus > Upstate Medical University
Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
Published: 4/19/2023   |   Inventor(s): Michael Sierks, Stephanie Williams
Keywords(s): Antibodies, Antigen-specific Therapies, Bioassay, biomarker, ELISA, Mental Disorders, Traumatic Brain Injury
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools
Recombinant Antibody Fragments that Selectively Target Oligomeric Tau Aggregates
Alzheimer's disease (AD) is one of the most prevalent and feared neurodegenerative diseases associated with aging, characterized by progressive neuronal loss and cognitive dysfunction. AD affects nearly 5 million Americans, and unfortunately, there is no cure as of yet. Numerous studies have implicated oligomeric amyloid beta (Aß) aggregates as...
Published: 4/19/2023   |   Inventor(s): Michael Sierks, Huilai Tian, James Moe, Eliot Davidowitz
Keywords(s): Antibodies, Antibody Therapeutics, Antigen-specific Therapies, Bioassay, Dementias, Diagnostics, Human aging, Protein, Therapeutics
Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Peptidomimetic-Based Antibody Surrogate for HER2
­Advantages: High affinity for HER2 and inhibits downstream signaling Potent anti-tumor effects Small molecular weight Resistant to proteolysis Summary: Current HER2-targeted therapies, including monoclonal antibody trastuzumab, are hindered by high cost of production, large molecular weight, and susceptibility to degradation. A novel...
Published: 8/24/2023   |   Inventor(s): Jianfeng Cai, Mengmeng Zheng
Keywords(s): Antibodies, Antiviral Therapeutics, Cancer, Peptides
Category(s): Technology Classifications > Cancer > Cancer Treatment Breast Cancer
Therapeutic Human Monoclonal Antibody (HUMAB) with Extremely Potent and Broadly Neutralizing Activity for Omicron and Other CoV-2 Variants
­​ Potent breadth and cross-reactivity of novel CoV2 neutralizing human monoclonal antibody that can neutralize the highly immune-evasive BQ.1/BQ.1.1 variants that are currently responsible for ≅ 50% of CoV2 infection in US. Invention Summary: The emergence of highly immune evasive SARS-CoV2 escape mutants require an immediate response...
Published: 4/21/2024   |   Inventor(s): Alok Choudhary, Abraham Pinter
Keywords(s): Antibodies, Respiratory Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Diagnostics
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