Search Results - inhibitor

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­COMPOUNDS AS GABA RECEPTOR MODULATORS
­COMPOUNDS AS GABA RECEPTOR MODULATORS Researchers at UCSF have developed novel GABA-modulating pharmaceutical compounds that are potential therapeutics for the treatment of chronic pain. Neurotransmitters are the building blocks of information transfer in the central nervous system and can modulate action potentials at the synapses of neurons...
Published: 12/5/2023   |   Inventor(s): Matthew McCarroll, Jason Sello, David Kokel, Allan Basbaum, Jarret Weinrich
Keywords(s): Inhibitor, Neuron, Pain
Category(s): Technology Classifications > Biology
Methods of Producing T-cell Populations Using P38 MAPK Inhibitors
Abstract: Adoptive cell therapy (ACT) uses cancer reactive T-cells to effectively treat patients. However, several obstacles inhibit the successful use of ACT for cancer treatment.  Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and...
Published: 4/8/2024   |   Inventor(s): Nicholas Restifo, Shashankkumar Patel
Keywords(s): Immunotherapy. Restifo, inhibitor, Mapk, P38, T-CELLS
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology
CORONAVIRUS NEUTRALIZING COMPOSITIONS AND ASSOCIATED METHODS
CORONAVIRUS NEUTRALIZING COMPOSITIONS AND ASSOCIATED METHODS Researchers at CZ Biohub SF and Stanford have developed unique fusion proteins that have broad therapeutic benefits for the treatment of infection by existing and future coronaviruses. Coronaviruses cause human illness ranging from the common cold to more severe diseases. They are large,...
Published: 7/27/2023   |   Inventor(s): Payton Weidenbacher, Peter Kim, Eric Waltari
Keywords(s): Antibody, Broad-Spectrum, Coronavirus, Fusion Protein, Highly-Conserved, Inhibitor, Neutralizing, Receptor, Variant
Category(s): Technology Classifications > Biology
MODULATING BONE MORPHOGENIC PROTEIN (BMP) SIGNALING IN THE TREATMENT OF ALZHEIMER’S DISEASE
MODULATING BONE MORPHOGENIC PROTEIN (BMP) SIGNALING IN THE TREATMENT OF ALZHEIMER’S DISEASE Researchers at Stanford University have described a novel therapeutic target for Alzheimer’s disease. Alzheimer’s disease (AD) presents a large public health burden, effecting an estimated 5.5 million people in the United States and occurring...
Published: 4/13/2023   |   Inventor(s): Michael Clarke, Jane Antony, Maddalena Adorno, Elizabeth Chen, Benedetta n di Robilant, Felicia Reinitz
Keywords(s): Alzheimer’s Disease, BMP, Inhibitor, Neural Progenitor, Stem Cell
Category(s): Technology Classifications > Biology
SIRT2 Inhibitors as Novel Therapeutics for Myocardial Infarction and Ischemic Stroke and to Prevent Necrosis
Sirtuin 2 (SIRT2) inhibitors to reduce necrosis and, thereby, as novel therapeutics to treat ischemic stroke and myocardial infarction. Accumulating evidence indicates that programmed necrosis plays a critical role in cell death during ischemia-reperfusion. NIH investigators have shown that the NAD-dependent deacetylase SIRT2 binds constitutively...
Published: 4/8/2024   |   Inventor(s): Toren Finkel, Nisha Narayan
Keywords(s): Against, AGK2, deacetylase, IB1FXX, IB1XXX, IBXXXX, inhibitor, IXXXXX, NAD-dependent, NB1HXX, NB1XXX, NBXXXX, NECROSIS, NXXXXX, PROTECTS, Sirt2
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Neurology
Novel Therapeutic Compounds for Treatment of Cancer and Immune Disorders
The global market for cancer therapeutics is over $40 billion and is anticipated to continue to rise in the future. There remains a significant unmet need for therapeutics for cancers that affect blood, bone marrow, and lymph nodes and the immune system, such as leukemia, multiple myeloma, and lymphoma. The proteasome inhibitor bortezomib, which may...
Published: 7/25/2024   |   Inventor(s): Yihong Ye, William Trenkle, Adrian Wiestner
Keywords(s): anti-cancer, Bortezomib, CANCER, CB5AXX, CB5EXX, CB5XXX, CB6XXX, CBXXXX, CXXXXX, DB4AXX, DB4XXX, DBXXXX, Diacyl, DXXXXX, ERAD, Hematologic, HYDRAZINE, Hydrazone, immunosuppressant, inhibitor, Patent Category - Chemistry, Proteasome, Proteasome inhibitor, retroviral, tumor
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology
Method of Producing Immortalized Primary Human Keratinocytes for HPV Investigation, Testing of Therapeutics, and Skin Graft Generation
One of the major limitations of using cultured keratinocytes for research studies is that primary keratinocytes senesce after a few passages. Keratinocytes from specific anatomical sites are also difficult to culture. Scientists at the NIH have demonstrated that primary keratinocytes, from several anatomical sites, when treated with a small-molecule...
Published: 7/25/2024   |   Inventor(s): Sandra Chapman, Jonathan Vogel, Atsushi Terunuma, Alison McBride
Keywords(s): AC4XXX, ACXXXX, AXXXXX, CC3XXX, CCXXXX, Complete, CXXXXX, DDXXXX, DXXXXX, EXTENDED, grafting, Human, IB2BXX, IB2XXX, IBXXXX, inhibitor, IXXXXX, KERATINOCYTES, Keratinocytes., Life-cycle, LONG-TERM, Maintenance, Papillomaviruses., Patent Category - Biotechnology, Persistence, Primary, PROLIFERATIVE, REPLICATION, ROCK, RXXXXX, SKIN, STATE, Studies., Sustain, Y-27632
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Dermatology, TherapeuticArea > Infectious Disease
Caspase Inhibitors Useful for the Study of Autoimmune or Inflammatory Diseases
Novel and potent caspase 1 inhibitors are available for licensing. In particular, this technology discloses potent and selective caspase 1 inhibitors that target the active site of the enzyme. Caspase 1 is known to play a pro-inflammatory role in numerous autoimmune and inflammatory diseases and therefore represents an excellent target for treatment...
Published: 7/25/2024   |   Inventor(s): Matthew Boxer, Craig Thomas
Keywords(s): 1, Amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis 1; Amyotrophic lateral scleros, Amyotrophic lateral sclerosis 6, Caspase, IB3XXX, IBXXXX, Inflammatory bowel disease 1, inhibitor, IXXXXX, Lou Gehrig's disease, Patent Category - Chemistry
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Immunology
Eeyarestatins: Novel Deubiquitination Inhibitors for the Treatment of Drug-Resistant Cancers
The ubiquitin-proteasome system has recently been recognized to play a central role in tumor biology. Bortezomib, an inhibitor of the chymotrypsin-like activity of the proteasome, has clinical activity in a variety of hematologic malignancies and is FDA approved for use in Multiple Myeloma and Mantle Cell Lymphoma. The present invention for the first...
Published: 7/25/2024   |   Inventor(s): Helena Mora-Jensen, Qiuyan Wang, Yihong Ye, Adrian Wiestner
Keywords(s): Active, Against, BBXXXX, Bortezomib, CANCER, CB5EXX, CB5XXX, CBXXXX, Cells, Chronic lymphocytic leukemia, COMPOSITION, CXXXXX, DB4AXX, DB4XXX, DBXXXX, Deubiquination, DXXXXX, Eeyarestatin, Hematologic, Highly, HIV AIDS - Therapeutics, Including, inhibitor, lymphoma, Mantle cell lymphoma, MULTIPLE MYELOMA, Proteasome, RESISTANT, That, tumor
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology
Collagen-Induced Platelet Aggregation Inhibitor from Mosquito Salivary Glands
Exposed collagen in injured blood vessels provides a substrate for platelets to adhere and aggregate initiating the first step in thrombosis, the formation of blood clots inside a blood vessel. Despite the essential role of platelets in vascular injury, excessive platelet aggregation may also result in thrombotic diseases such as stroke and heart attack. Available...
Published: 7/25/2024   |   Inventor(s): Eric Calvo
Keywords(s): AGGREGATION, Collagen-platelet, GLANDS, IB1EXX, IB1XXX, IB3XXX, IBXXXX, inhibitor, IXXXXX, Malaria, Mosquito, Salivary
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Therapeutics
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