Search Results - antiviral

22 Results Sort By:
Modified griffithsin tandemers for enhanced activity and reduced viral aggregation
Abstract: Griffithsin (GRFT) is a lectin with potent antiviral properties that is capable of preventing and treating infections caused by a number of enveloped viruses (including HIV, SARS, HCV, HSV, and Japanese encephalitis) and is currently in clinical development as an anti-HIV microbicide. In addition to its broad antiviral activity, GRFT is stable...
Published: 4/8/2024   |   Inventor(s): Barry O'Keefe, Alexander Wlodawer, Tinoush Moulaei
Keywords(s): ANTIVIRAL, mGRFT tandemers
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics
Tempol as a Therapeutic to Treat Covid-19 Via Inhibition of Viral Replication
Abstract: Despite several partially effective prophylactic vaccines for SARS-CoV-2 exist, patients worldwide still succumb to COVID-19. New therapeutics to treat this disease are still needed.  Upon host invasion, a critical step in the pathogenesis of COVID-19 is intracellular replication of SARS-CoV-2 before viral particles invade nearby healthy cells....
Published: 4/8/2024   |   Inventor(s): Tracey Rouault, William Linehan, Nunziata Maio
Keywords(s): ANTIVIRAL, COVID-19, RdRP Inhibitor, RNA-dependent RNA Polymerase inhibitor, Rouault, SARS-CoV-2, Tempol
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology
A Triple Combination HIV Microbicide
Abstract: The HIV-positive population continues to rise despite a worldwide decline in the rates of infection caused by human immunodeficiency virus (HIV).  The HIV virus continues to spread due to a lack of effective vaccines and pre-exposure prophylaxis methods, even though the availability and effectiveness of antiretroviral therapy has helped reduce...
Published: 4/8/2024   |   Inventor(s): Barry O'Keefe, Paul Christou, Evangelia Vavamka, Theresa Capell
Keywords(s): Acquired Immunodeficiency Syndrome, ANTIBODY, ANTIVIRAL, HIV, Lectin, Microbicide, O’Keefe, Sexually Transmitted Diseases
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease
Plant-based system for generation of single-domain antibodies to combat viral infections
Plant-derived antibodies designed to target SARS- CoV-2 bind to SARS-CoV2 spike protein similar to bacteria derived antibodies based on ELISA. Invention Summary: The use of neutralizing antibodies is a strategy for treating viral infections, especially for individuals who are immunocompromised or have high-risk medical conditions. Mass production...
Published: 4/21/2024   |   Inventor(s): Tamara Minko, Natalia Pogrebnyak, Andrew Shen, Obeid Malekshah
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 8/20/2024   |   Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
Simple, Rapid, and Sensitive Real-Time PCR Assays for Detecting Drug Resistance of HIV
This novel assay features real-time PCR reagents and methods for detecting drug-resistance related mutations in HIV, for newly diagnosed patients and those individuals currently receiving antiretroviral therapies. As the use of antiretroviral compounds to treat HIV infection proliferates, viruses adapt and evolve mutations limiting the efficacy of...
Published: 7/25/2024   |   Inventor(s): Jonathan Lipscomb, Walid Heneine, Jeffrey Johnson
Keywords(s): 1, ANTIVIRAL, Anti-Viral, ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4XXX, DAXXXX, DETECTING, DRUGS, DXXXXX, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, MUTATION, NCHHSTP-DHPSE, OID-NCHHSTP-DHPSE, PCR, POINT, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REAL-TIME, Resistance, VLXXXX, VPXXXX, WBXXXX, WFXXXX, XBXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Occupational Safety and Health, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology, Application > Research Materials, ResearchProducts > Computational models/software, Application > Consumer Products, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease
Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples
One of the problems with the development of current therapies for HIV infection is that the virus rapidly develops resistance to drugs such as reverse transcriptase (RT) inhibitors. CDC researchers have developed an enzyme-based methodology for detecting phenotypic resistance to antiretroviral drugs whose mode of action decreases the efficiency of...
Published: 7/25/2024   |   Inventor(s): Gerardo Lerma, Shinji Yamamoto, William Switzer, Thomas Folks, Walid Heneine
Keywords(s): ANTIVIRAL, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, DB4AXX, DETECTING, DRUGS, DXXXXX, KIT, Method, OID-NCHHSTP-DHPSE, Resistance, VLXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Occupational Safety and Health, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics
CC Chemokine Receptor 5 DNA, New Animal Models and Therapeutic Agents for HIV Infection
Chemokine receptors are expressed by many cells, including lymphoid cells, and function to mediate cell trafficking and localization. CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells....
Published: 7/25/2024   |   Inventor(s): Christopher Broder, Philip Murphy, Ghalib Alkhatib, Edward Berger, Yu Feng, Paul Kennedy, Christophe Combadiere
Keywords(s): 5, Agents, AIDS, also designated as CKR5, ANIMAL, antiretroviral, ANTIVIRAL, cc, CC-CKR5 chemokine receptor, CCR5 and CMKBR5, Chemokine, DB4AXX, DB4XXX, DBXXXX, DDXXXX, DNA, DXXXXX, HIV, Hyper IgM syndrome, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Infection, MIP-1a & MIP-1b, Models, Patent Category - Biotechnology, Patent Category - Contested Proceedings, RECEPTOR, receptor for RANTES, Severe combined immunodeficiency, x-linked, therapeutic, Wiskott Aldrich syndrome
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
​ S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.​ Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 5/8/2024   |   Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
mRNA Therapeutic Against the SARS-CoV-2 Spike Protein
Background Vaccines have shown great efficacy against SARS-CoV-2, the pathogen of COVID-19; however, methods of treatment are required for patients suffering from COVID‑19. More than 15 million cases with over 600,000 deaths have resulted from the ongoing coronavirus disease 2019 (COVID-19). SARS-CoV-2, the pathogen of COVID-19, is a β-coronavirus...
Published: 8/4/2022   |   Inventor(s): Gaurav Sahay, Anindit Mukherjee, Jeonghwan Kim
Keywords(s): antiviral, Drug, Drug Delivery, mRNA, mRNA carrier, mRNA delivery
Category(s): Therapeutics
1 2 3